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TRPV1 polymorphisms and risk of interferon β-induced flu-like syndrome in patients with relapsing-remitting multiple sclerosis.

Abstract：

:Interferon-β (IFN-β) is often discontinued in RRMS patients due to its most common side effect, the flu-like syndrome (FLS). The mechanisms underlying IFN β-induced FLS symptoms are still unclear. The endocannabinoid system (ECS) is a key regulator of pain and inflammation. Thus we tested the hypothesis that the ECS could be involved in FLS severity by exploring the effect of genetic polymorphisms with functional impact on the ECS, on patient-reported FLS symptoms. GG-carriers of the transient-receptor-potential-vanilloid-1 (TRPV1) single nucleotide polymorphism rs222747 reported greater pain and weakness during FLS. This study suggests that the TRPV1 channel is involved in FLS severity.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Buttari F,Zagaglia S,Marciano L,Albanese M,Landi D,Nicoletti CG,Mercuri NB,Silvestrini M,Provinciali L,Marfia GA,Mori F,Centonze D

doi

10.1016/j.jneuroim.2017.02.007

subject

Has Abstract

pub_date

2017-04-15 00:00:00

pages

172-174

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(16)30424-6

journal_volume

305

pub_type

杂志文章

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