Two HLA class I genes independently associated with multiple sclerosis.

abstract：:Multiple sclerosis (MS) is a devastating autoimmune demyelinating disease of the central nervous system (CNS). This study investigated whether expression and activity of the calcium-activated protease calpain correlated with Th1/Th2 dysregulation in MS patients during states of relapse and remission. Calpain expressio...

journal_title：Journal of neuroimmunology

authors： Imam SA,Guyton MK,Haque A,Vandenbark A,Tyor WR,Ray SK,Banik NL

更新日期：2007-10-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) is an important autoantigen in multiple sclerosis and in experimental autoimmune encephalomyelitis (EAE). We generated a T cell receptor (TCR) transgenic (Tg) mouse expressing a TCR derived from an encephalitogenic T cell clone specific for MOG(35-55). This mouse failed to dev...

journal_title：Journal of neuroimmunology

authors： Mendel I,Natarajan K,Ben-Nun A,Shevach EM

更新日期：2004-04-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) was taken from guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis (CR-EAE). The leucocytes in CSF samples were counted and subjected to immunocytochemical analysis using monoclonal antibodies selectively recognising guinea pig T cells, macrophages or Ia...

journal_title：Journal of neuroimmunology

authors： Suckling AJ,Baron PW,Mauer U,Burger R,Rumsby MG

更新日期：1986-03-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) has led to the identification of widespread brain abnormalities in multiple sclerosis (MS) that extend far beyond the classic white matter lesion. These findings have generated the idea that MS should be understood as a disease of the whole brain, not just the white matter. While it is...

journal_title：Journal of neuroimmunology

authors： Reich DS

更新日期：2017-03-15 00:00:00

abstract：:We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-γ secreting cells following stimulation with autologous EBV-infected lymphobl...

journal_title：Journal of neuroimmunology

authors： Lindsey JW,Hatfield LM

更新日期：2010-12-15 00:00:00

abstract：:Plasma B cells secrete immunoglobulinfree light chains (IgLC) which by binding to mast cells can mediate hypersensitivity responses and are involved in several immunological disorders. To investigate the effects of antigen-specific IgLC activation, intracellular recordings were made from cultured murine dorsal root ga...

journal_title：Journal of neuroimmunology

authors： Rijnierse A,Kraneveld AD,Salemi A,Zwaneveld S,Goumans AP,Rychter JW,Thio M,Redegeld FA,Westerink RH,Kroese AB

更新日期：2013-11-15 00:00:00

abstract：:B lymphocytes play an important role in the pathogenesis of multiple sclerosis (MS). Follicle-like structures (FLS) have recently been found in the subarachnoid space in the leptomeninges in some patients with secondary progressive MS (SPMS). They contain proliferating B lymphocytes, plasma cells, helper T lymphocytes...

journal_title：Journal of neuroimmunology

authors： Haugen M,Frederiksen JL,Degn M

更新日期：2014-08-15 00:00:00

abstract：:Reactive oxygen intermediates (ROIs) are important mediators of a variety of pathological processes, including inflammation and ischemia/reperfusion injury. Cytokines and chemokines are detected at mRNA level in human and animal ischemic brains. This suggests that hypoxia/reoxygenation may induce cytokine production t...

journal_title：Journal of neuroimmunology

authors： Wang MJ,Huang HM,Hsieh SJ,Jeng KC,Kuo JS

更新日期：2001-01-01 00:00:00

abstract：:Depression and chronic fatigue are frequently present in multiple sclerosis (MS); however, the prevalence rates have not been investigated in neuromyelitis optica (NMO). Thirty-nine consecutive NMO and 75 MS patients were compared using self-rating questionnaires for depressive states, daily activity, and fatigue, as ...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Nakashima I,Misu T,Fujihara K,Aoki M

更新日期：2015-06-15 00:00:00

abstract：:Administration of beta-receptor agonists alleviate experimental multiple sclerosis (MS) in animal models. In this study, we investigated the effects of terbutaline (5 mg) on IL-10, IL-12, IFN-gamma and TNF-alpha production in whole blood stimulation cultures. IL-10 and IL-12 production were significantly enhanced in c...

journal_title：Journal of neuroimmunology

authors： Heesen C,Gold SM,Sondermann J,Tessmer W,Schulz KH

更新日期：2002-11-01 00:00:00

abstract：:Using congenic strains of mice susceptible (bcg(s)) or resistant (bcg(r)) to BCG, murine microglial cell lines, RR4.R (BCG-resistant) and RR8.S (BCG-susceptible), were established in vitro. Comparative studies revealed that, although phagocytic to a similar extent, RR4.R cells were more active than RR8.S cells in term...

journal_title：Journal of neuroimmunology

authors： Puliti M,Mazzolla R,Brozzetti A,Neglia R,Radzioch D,Bistoni F,Blasi E

更新日期：1999-11-01 00:00:00

abstract：:CCR7 and CD45RA expression on CD4+ and CD8+ T-cells in blood (PB) of 16 patients with multiple sclerosis (MS) and 16 healthy controls and cerebrospinal fluid (CSF) of 10 patients suffering from MS were analysed by flow cytometric measurements. T-cells were divided by their distinct homing potentials and effector-funct...

journal_title：Journal of neuroimmunology

authors： Haegele KF,Stueckle CA,Malin JP,Sindern E

更新日期：2007-02-01 00:00:00

abstract：:In this report, the role of STAT4 and local production of interleukin (IL)-12 in the central nervous system (CNS) were examined during experimental vesicular stomatitis virus (VSV) encephalitis. We have previously shown that IL-12 treatment is beneficial both in vitro and in vivo during experimental VSV infection. Thi...

journal_title：Journal of neuroimmunology

authors： Chesler DA,Reiss CS

更新日期：2002-10-01 00:00:00

abstract：:Acute flaccid paralysis is a neuromuscular emergency characterized by rapidly worsening weakness that evolves quickly to cause diaphragmatic failure. The challenge for the treating physician is to stabilize the patient, generate the differential diagnosis and determine the management; all in quick time. Neurotoxic sna...

journal_title：Journal of neuroimmunology

authors： Sundar K,Venkatasubramanian S,Shanmugam S,Arthur P,Subbaraya R,Hazeena P

更新日期：2017-10-15 00:00:00

abstract：:Cells that produce tumor necrosis factor-alpha (TNF-alpha) require the presence of signaling molecules since this cytokine is not normally expressed in a constitutive manner. It has been demonstrated that glial cells can produce TNF-alpha; however, the specific inducing molecules and their mechanism(s) of action have ...

journal_title：Journal of neuroimmunology

authors： Bethea JR,Chung IY,Sparacio SM,Gillespie GY,Benveniste EN

更新日期：1992-02-01 00:00:00

abstract：:In the present study, we investigated the B-cell translocation gene 1 (BTG1) as a candidate for multiple sclerosis (MS) susceptibility. BTG1 is a member of a family of genes involved in the apoptotic process. We genotyped two SNPs of the BTG1 gene (rs731652 and rs12694) in 550 MS patients and 548 controls. For SNP rs7...

journal_title：Journal of neuroimmunology

authors： Camiña-Tato M,Morcillo-Suárez C,Navarro A,Fernández M,Horga A,Montalban X,Comabella M

更新日期：2009-08-18 00:00:00

abstract：:Lactogen-dependent Nb2 cell lines have been widely employed to investigate signaling mechanisms coupled to prolactin receptor (PRLR)-stimulated transcription of hormone-responsive genes. We previously reported that PRL rapidly induced expression of the immediate-early protooncogene, pim-1. In the present report, we de...

journal_title：Journal of neuroimmunology

authors： Buckley AR

更新日期：2000-09-01 00:00:00

abstract：:The central nervous system plays an active role in the regulation of the immune system. Modulation of immune activities appears to be in part under the control of the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the effect of a muscarinic cholinergic agonist, arecoline, which stimulates the secretion of ...

journal_title：Journal of neuroimmunology

authors： Demissie S,Rogers CF,Hiramoto NS,Ghanta VK,Hiramoto RN

更新日期：1995-06-01 00:00:00

abstract：:Human monoclonal IgM antibodies present in the blood of some patients with peripheral neuropathy and murine hybrid IgM antibodies C5 and C6, raised against myelin-associated glycoprotein, and HNK-1, raised against the human T cell line HSB-2, all bind to the carbohydrate moiety of myelin-associated glycoprotein. The r...

journal_title：Journal of neuroimmunology

authors： Miller SL,Kahn SN,Perussia B,Trinchieri G

更新日期：1987-07-01 00:00:00

abstract：:Microglial activation is the most common phenomenon in S. aureus induced brain abscesses as well as other common neurodegenerative diseases. The main objective of this study is to reduce the microglial inflammation with effective bacterial elimination. Ciprofloxacin and celecoxib were used in combination to regulate S...

journal_title：Journal of neuroimmunology

authors： Dey R,Sultana S,Bishayi B

更新日期：2018-03-15 00:00:00

abstract：:Recent studies suggest that monocyte activation may play a role in ALS pathogenesis. Therefore, monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), and plasma levels of MCP-1 were measured in 42 sALS patients, 38 healthy and 34 age-related macular degeneration (ARMD) controls. MCP-1 was elevate...

journal_title：Journal of neuroimmunology

authors： Zhang R,Gascon R,Miller RG,Gelinas DF,Mass J,Lancero M,Narvaez A,McGrath MS

更新日期：2006-10-01 00:00:00

abstract：:The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of p...

journal_title：Journal of neuroimmunology

authors： Delunardo F,Margutti P,Pontecorvo S,Colasanti T,Conti F,Riganò R,Profumo E,Siracusano A,Capozzi A,Prencipe M,Sorice M,Francia A,Ortona E

更新日期：2007-12-01 00:00:00

abstract：:CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leuko...

journal_title：Journal of neuroimmunology

authors： Thelen M,Thelen S

更新日期：2008-07-31 00:00:00

abstract：:HIV-1 expression in monocytes/macrophages can be controlled by transforming growth factor-beta 1 (TGF-beta 1). TGF-beta 1 is present in astrocytes surrounding HIV-1-infected monocyte/macrophages in brain tissue from patients with AIDS but not from seronegative, normal individuals. We sought to determine whether or not...

journal_title：Journal of neuroimmunology

authors： da Cunha A,Jackson RW,Vitković L

更新日期：1995-07-01 00:00:00

abstract：:The role of autoantibody responses in pathogenesis or progression of multiple sclerosis (MS) remains controversial. This is partly because the methods that can distinctly identify pathogenic antibody reactivities targeting native membrane proteins from the reactivities that originate as an epiphenomenon in such diseas...

journal_title：Journal of neuroimmunology

authors： Aslam M,Kalluri SR,Cepok S,Kraus V,Buck D,Srivastava R,Hemmer B

更新日期：2010-04-15 00:00:00

abstract：:In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to assess the changes in the two nerve systems. Following long...

journal_title：Journal of neuroimmunology

authors： Van Ranst L,Lauweryns JM

更新日期：1990-09-01 00:00:00

abstract：:To elucidate the factor(s) accelerating the autoimmune disease processes, we induced two types of experimental autoimmune encephalomyelitis (EAE), severe and very mild, in F344 rats by immunization with myelin basic protein (MBP) plus pertussis toxin (PT) (PT+) or with MBP alone (PT-) and compared the differences betw...

journal_title：Journal of neuroimmunology

authors： Arimoto H,Tanuma N,Jee Y,Miyazawa T,Shima K,Matsumoto Y

更新日期：2000-04-03 00:00:00

abstract：:Inflammatory mediators have been proposed to play a critical role in the pathogenesis of choroidal neovascularization, a blinding complication of age-related macular degeneration. We evaluated the expression of TNF-alpha in human choroidal neovascular membranes and found that it colocalized with cells expressing VEGF,...

journal_title：Journal of neuroimmunology

authors： Hangai M,He S,Hoffmann S,Lim JI,Ryan SJ,Hinton DR

更新日期：2006-02-01 00:00:00

abstract：:It has been reported that obesity leads to more marked inflammatory responses in a site-specific manner. As has been seen in other animal models of obesity, ovariectomized rodents exhibit obesity and exacerbated fever and anorectic responses to the systemic injection of lipopolysaccharide (LPS). Furthermore, they also...

journal_title：Journal of neuroimmunology

authors： Iwasa T,Matsuzaki T,Tungalagsuvd A,Munkhzaya M,Kawami T,Kato T,Kuwahara A,Yasui T,Irahara M

更新日期：2014-12-15 00:00:00

abstract：:DNA damage-, DNA repair-, and apoptosis-related gene expression in CD3(+) T lymphocytes of BALB/c mice subjected to 2-h restraint stress were compared to that in CD3(+)T lymphocytes from control mice. Using targeted cDNA arrays, significant increases in expression of genes serving as sensors of DNA damage, including M...

journal_title：Journal of neuroimmunology

authors： Flint MS,Carroll JE,Jenkins FJ,Chambers WH,Han ML,Baum A

更新日期：2005-10-01 00:00:00