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Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis.

Abstract：

:In the present study, we investigated the B-cell translocation gene 1 (BTG1) as a candidate for multiple sclerosis (MS) susceptibility. BTG1 is a member of a family of genes involved in the apoptotic process. We genotyped two SNPs of the BTG1 gene (rs731652 and rs12694) in 550 MS patients and 548 controls. For SNP rs731652, significant associations with relapse-onset MS were found at the allele and genotype levels when compared with controls. We identified a risk haplotype associated with relapse-onset MS. These findings support the hypothesis that BTG1 polymorphisms may influence genetic predisposition for MS, especially in relapse-onset MS patients.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Camiña-Tato M,Morcillo-Suárez C,Navarro A,Fernández M,Horga A,Montalban X,Comabella M

doi

10.1016/j.jneuroim.2009.05.010

subject

Has Abstract

pub_date

2009-08-18 00:00:00

pages

142-7

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(09)00204-5

journal_volume

213

pub_type

杂志文章

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