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A novel protective model against experimental allergic encephalomyelitis in mice expressing a transgenic TCR-specific for myelin oligodendrocyte glycoprotein.

Abstract：

:Myelin oligodendrocyte glycoprotein (MOG) is an important autoantigen in multiple sclerosis and in experimental autoimmune encephalomyelitis (EAE). We generated a T cell receptor (TCR) transgenic (Tg) mouse expressing a TCR derived from an encephalitogenic T cell clone specific for MOG(35-55). This mouse failed to develop EAE spontaneously and developed mild EAE at late onset when immunized with MOG(35-55). The Tg T cells produced large amounts of IL-4 when stimulated with MOG(35-55) and underwent FAS/FAS-L-mediated activation-induced cell death when stimulated with MOG(35-55) and IL-12. The unique phenotype of these autoantigen-specific T cells may represent an important mechanism of protection against autoimmune disease.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Mendel I,Natarajan K,Ben-Nun A,Shevach EM

doi

10.1016/j.jneuroim.2003.12.007

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

10-21

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572803005393

journal_volume

149

pub_type

杂志文章

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