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Delayed type skin response to myelin basic protein in chronic relapsing experimental allergic encephalomyelitis.

Abstract：

:The skin response to myelin basic protein (MBP) was studied in chronic relapsing experimental allergic encephalomyelitis (EAE) using strain 13 guinea pigs. The delayed type skin response showed a monophasic curve; it gradually increased after immunization, reached maximum levels around 80 days post-immunization, and decreased thereafter. Relapses were more frequent while it was at high levels although it did not correlate directly in individuals with the clinical stage. The skin response was also high in MBP-immunized animals which had recovered from acute EAE. Our results suggest that delayed type hypersensitivity to MBP is involved but is not sufficient by itself to cause relapsing EAE.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Tabira T,Itoyama Y,Kuroiwa Y,Kubo C,Nagai Y

doi

10.1016/0165-5728(83)90050-4

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

295-304

issue

3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(83)90050-4

journal_volume

5

pub_type

杂志文章

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