Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons.


:Neuronal damage in Alzheimer's disease (AD) is thought to involve direct toxicity of beta-amyloid peptide (Abeta) and excitotoxicity involving NMDA receptors (NMDARs) and altered Ca(2+) dynamics. Inflammation agents produced by microglia or astrocytes and associated with senile plaques such as the cytokine interleukin-6 (IL-6) could also contribute. To investigate this possibility, neuronal damage (lactate dehydrogenase assay, LDH, assay) was measured in cultures of rodent cortical neurons chronically treated with IL-6, Abeta or Abeta plus IL-6 and acutely treated with NMDA. Both Abeta and NMDA produced neuronal damage and this effect was larger with combined treatment. IL-6 did not produce significant neuronal damage but the largest neuronal damage was observed in cultures exposed to all three factors. IL-6 and Abeta enhanced Ca(2+) responses to NMDA and combined treatment produced the largest effect. These results are consistent with a role for interactions between Abeta, NMDA and IL-6 in the neuronal loss in AD.


J Neuroimmunol


Qiu Z,Gruol DL




Has Abstract


2003-06-01 00:00:00














  • Studies on the intrathecal humoral immune response in canine distemper encephalitis.

    abstract::Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Vandevelde M,Zurbriggen A,Steck A,Bichsel P

    更新日期:1986-03-01 00:00:00

  • Differential immune responses in mice with left- and right-turning preference.

    abstract::Humoral and cell-mediated immune responses of inbred BALB/c male mice were assayed for differential reactivities associated with behavioral sidedness, which was evaluated by spontaneous rotational behavior in a circular cage model system. Mice with left-turning preference had lower in vivo primary IgM and IgG anti-Key...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kim D,Carlson JN,Seegal RF,Lawrence DA

    更新日期:1999-01-01 00:00:00

  • Progressive multifocal leukoencephalopathy.

    abstract::Progressive multifocal leukoencephalopathy (PML) is a disease of the central nervous system (CNS) with destructive infection of oligodendrocytes by JC virus. PML belongs to the opportunistic infections. It is observed in patients with HIV infection, lymphoid malignancies, after organ- and stem cell transplantations an...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Weissert R

    更新日期:2011-02-01 00:00:00

  • Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis.

    abstract::B cells are of increasing importance as a target for multiple sclerosis treatment. Here we show that GA treatment of mice with experimental autoimmune encephalomyelitis (EAE) biases cytokine production by B cells towards cytokines associated with regulation in MS including interleukin (IL)-4, -10 and -13 and reduces p...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Begum-Haque S,Sharma A,Christy M,Lentini T,Ochoa-Reparaz J,Fayed IF,Mielcarz D,Haque A,Kasper LH

    更新日期:2010-02-26 00:00:00

  • Microglia-derived IGF-2 prevents TNFalpha induced death of mature oligodendrocytes in vitro.

    abstract::Insulin-like growth factor-2 (IGF-2) present in media conditioned by non-activated and interferon gamma (IFN gamma)-treated microglia reduces galactocerebroside(+) (GalC) oligodendrocyte apoptosis in cultures derived both from the CG4 cell line and primary rat cortices. Microglia-derived IGF-2 also acts in each cultur...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Nicholas RS,Stevens S,Wing MG,Compston DA

    更新日期:2002-03-01 00:00:00

  • Identification and functional characterization of a highly polymorphic region in the human TRAIL promoter in multiple sclerosis.

    abstract::TNF-related apoptosis-inducing ligand (TRAIL) is not only involved in cell death but also in other immunoregulatory mechanisms. So far, the regulation of the TRAIL pathway in physiologic and pathologic conditions remains unclear. Due to the implication in brain damage and the elevated expression in peripheral immune c...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Weber A,Wandinger KP,Mueller W,Aktas O,Wengert O,Grundström E,Ehrlich S,Windemuth C,Kuhlmann T,Wienker T,Brück W,Zipp F

    更新日期:2004-04-01 00:00:00

  • Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromes.

    abstract::We evaluated the concentration of antineuronal antibodies in paired cerebrospinal fluid (CSF) and serum samples from 19 patients with central and peripheral paraneoplastic neurological syndromes (PNS), using an enzyme linked immunosorbent assay (ELISA) employing recombinant antineuronal antigens (HuD, Yo, Ri, CV2/CRMP...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Stich O,Jarius S,Kleer B,Rasiah C,Voltz R,Rauer S

    更新日期:2007-02-01 00:00:00

  • The structure of a myelin basic protein-associated idiotope.

    abstract::A cross-reactive idiotope (CRI) has been previously described on monoclonal antibodies (mAbs) specific for encephalitogenic peptides from myelin basic protein (MBP). The anti-CRI mAb, F25F7, binds an idiotope (Id) localized to the light chains of an anti-MBP peptide 1-9 mAb, denoted F23C6, and an anti-MBP peptide 80-8...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Maier CC,LeBoeuf RD,Zhou SR,Whitaker JN,Jarpe MA,Blalock JE

    更新日期:1993-07-01 00:00:00

  • Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) in humans with multiple sclerosis.

    abstract::Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to demyelination and neurodegeneration. VIP and PACAP are structurally related neuropeptides with neuroprotective and anti-inflammatory activities. To evaluate VIP and PACAP-38 in plasma and CSF in humans in correla...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Baranowska-Bik A,Kochanowski J,Uchman D,Wolinska-Witort E,Kalisz M,Martynska L,Baranowska B,Bik W

    更新日期:2013-10-15 00:00:00

  • The immune profile of multiple sclerosis: T-lymphocyte effects predominate over all other factors in cyclophosphamide-treated patients.

    abstract::It is widely believed that multiple sclerosis is a T-cell mediated autoimmune disease associated with abnormalities in immunoregulation. This large, prospective study evaluated the lymphocyte immunophenotypic profile of 246 MS patients, divided clinically into a remitting/relapsing group (n = 176) and a progressive gr...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Strauss K,Hulstaert F,Deneys V,Mazzon AM,Hannet I,De Bruyère M,Reichert T,Sindic CJ

    更新日期:1995-12-31 00:00:00

  • Visualization of inflammation and demyelination in 2D2 transgenic mice with rodent MRI.

    abstract::Research tools are urgently needed to elucidate the specificities of NMO and MS due to their clinical similarity at the early stage of the diseases. Herein, using high-field-strength MRI we characterized the optic nerve and spinal cord lesions in 2D2(tg) mice (MOG 35-55 specific TCR). Specifically, early Blood-brain B...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Bell JC,Liu Q,Gan Y,Liu Q,Liu Y,Shi FD,Turner GH

    更新日期:2013-11-15 00:00:00

  • Treatment with atacicept enhances neuronal cell death in a rat model of optic neuritis.

    abstract::We investigated the effect of atacicept, a recombinant fusion protein blocking BLyS and APRIL and acting on B cells, on degeneration of retinal ganglion cells (RGCs) during experimental autoimmune encephalomyelitis (EAE). We used myelin oligodendrocyte glycoprotein in Brown Norway rats to induce a variant of EAE which...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kretzschmar B,Hein K,Moinfar Z,Könnecke B,Sättler MB,Hess H,Weissert R,Bähr M

    更新日期:2014-03-15 00:00:00

  • Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts.

    abstract::IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFalpha-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFalpha to...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Strle K,McCusker RH,Tran L,King A,Johnson RW,Freund GG,Dantzer R,Kelley KW

    更新日期:2007-08-01 00:00:00

  • Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-alpha and blood-brain barrier damage.

    abstract::The mechanism for the initiation of blood-brain barrier damage and intrathecal inflammation in multiple sclerosis (MS) is poorly understood. We have recently reported that levels of tumor necrosis factor-alpha (TNF-alpha) correlate with blood-brain barrier damage in patients with active MS. Stimulation of endothelial ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sharief MK,Noori MA,Ciardi M,Cirelli A,Thompson EJ

    更新日期:1993-03-01 00:00:00

  • Temporal variations of adhesion molecules and matrix metalloproteinases in the course of MS.

    abstract::Thirty patients with clinically isolated syndromes (CIS) were evaluated at the onset of neurological symptoms and when they developed clinically definite MS (CDMS). Surface expression of LFA-1alpha, VLA-4 and intercellular adhesion molecule-1 (ICAM-1) on PBMC and CSF cells was evaluated using flow cytometry. Serum and...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Correale J,Bassani Molinas Mde L

    更新日期:2003-07-01 00:00:00

  • Participation of iNOS-derived NO in hypothalamic activation and vasopressin release during polymicrobial sepsis.

    abstract::Clinical and experimental studies with LPS injection have shown an increase in vasopressin (AVP) secretion in the early phase of severe sepsis, which is subsequently reduced despite persistent hypotension. The aim of this study was to evaluate the role of inducible nitric oxide synthase (iNOS)-derived NO in hypothalam...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Corrêa PB,Pancoto JA,de Oliveira-Pelegrin GR,Cárnio EC,Rocha MJ

    更新日期:2007-02-01 00:00:00

  • Complementary strategies to elucidate T helper cell epitopes in myasthenia gravis.

    abstract::CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Inv...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Jung C,Stoeckle C,Wiesmüller KH,Laub R,Emmrich F,Jung G,Melms A

    更新日期:2008-09-15 00:00:00

  • Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration.

    abstract::Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We o...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: García-Pérez D,Luisa Laorden M,Núñez C,Victoria Milanés M

    更新日期:2014-09-15 00:00:00

  • CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis.

    abstract::We simultaneously measured 16 cytokines/chemokines in cerebrospinal fluid (CSF) from 14 patients with acute disseminated encephalomyelitis (ADEM) and 20 controls using a fluorescent bead-based immunoassay. A variety of cytokines, such as IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IFN-gamma, TNF-alpha, G-CSF and MI...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Ishizu T,Minohara M,Ichiyama T,Kira R,Tanaka M,Osoegawa M,Hara T,Furukawa S,Kira J

    更新日期:2006-06-01 00:00:00

  • Interferon-γ potentiates GABAA receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons.

    abstract::The neural transmission and plasticity can be differentially modulated by various elements of the immune system. Interferon-γ (IFN-γ) is a "pro-inflammatory" cytokine mainly produced by T lymphocytes, activates its corresponding receptor and plays important roles under both homeostatic and inflammatory conditions. How...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Flood L,Korol SV,Ekselius L,Birnir B,Jin Z

    更新日期:2019-12-15 00:00:00

  • Characterization of serotonin transporter in blood lymphocytes of rats. Modulation by in vivo administration of mitogens.

    abstract::Serotonin transporter sites were characterized in blood lymphocytes of rats. Pharmacological characteristics of drug interactions were in concordance with recent studies in nervous and human immune cells. The potency order of inhibition of [(3)H]paroxetine binding was imipramine>citalopram>alaproclate>serotonin. Selec...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Cedeño N,Urbina M,Obregón F,Lima L

    更新日期:2005-02-01 00:00:00

  • Interstrain variability of autoimmune encephalomyelitis in rats: multiple encephalitogenic myelin basic protein epitopes for DA rats.

    abstract::We investigated T cell epitopes of guinea pig myelin basic protein (MBP) that induce experimental autoimmune encephalomyelitis (EAE) in DA rats, using synthetic peptides that correspond to regions of the guinea pig MBP molecule that are homologous to rat MBP. Four peptides were encephalitogenic when tested in DA rats....

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Stepaniak JA,Wolf NA,Sun D,Swanborg RH

    更新日期:1997-09-01 00:00:00

  • The role of macrophages in demyelination.

    abstract::Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS). In particular in the CsA-induced chronic relapsing form (CREAE), pronounced demyelination occurs, in temporal association with relapses. It is still a matter of discussion which cell type ultimately...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Dijkstra CD,De Groot CJ,Huitinga I

    更新日期:1992-10-01 00:00:00

  • Macrophage-colony stimulating factor (M-CSF) in the cerebrospinal fluid.

    abstract::In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Gallo P,Pagni S,Giometto B,Piccinno MG,Bozza F,Argentiero V,Tavolato B

    更新日期:1990-09-01 00:00:00

  • Granulocyte-macrophage colony-stimulating factor as a mediator of autoimmunity in multiple sclerosis.

    abstract::Autoreactive, myelin-specific, CD4+ T cells have a central role in multiple sclerosis (MS) pathogenesis; however the exact phenotype characteristics of these cells remain elusive. Recently, granulocyte-macrophage colony-stimulating factor (GM-CSF) expression has emerged as the main pathological signature of the enceph...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Kostic M,Zivkovic N,Cvetanovic A,Stojanovic I

    更新日期:2018-10-15 00:00:00

  • Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder.

    abstract::Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Bo M,Niegowska M,Arru G,Sechi E,Mariotto S,Mancinelli C,Farinazzo A,Alberti D,Gajofatto A,Ferrari S,Capra R,Monaco S,Sechi G,Sechi LA

    更新日期:2018-05-15 00:00:00

  • In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) has well recognized effects on cerebral endothelial cells and, therefore, may mediate disruption of blood-brain barrier in patients with multiple sclerosis (MS). To evaluate the in vivo relationship of TNF-alpha to blood-brain barrier impairment in MS, levels of this cytokine in...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sharief MK,Thompson EJ

    更新日期:1992-05-01 00:00:00

  • No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS.

    abstract::Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D. We analyzed the frequencies of two polymorphisms (codon 416 and codon 420) in the DBP gene through a case-control study involving 107 Japanese patients with multiple sclerosis (MS) and 109 heal...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Niino M,Kikuchi S,Fukazawa T,Yabe I,Tashiro K

    更新日期:2002-06-01 00:00:00

  • MyD88-dependent and -independent signalling via TLR3 and TLR4 are differentially modulated by Δ9-tetrahydrocannabinol and cannabidiol in human macrophages.

    abstract::Toll-like receptors (TLRs) are sensors of pathogen-associated molecules that trigger inflammatory signalling in innate immune cells including macrophages. All TLRs, with the exception of TLR3, promote intracellular signalling via recruitment of the myeloid differentiation factor 88 (MyD88) adaptor, while TLR3 signals ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Fitzpatrick JM,Minogue E,Curham L,Tyrrell H,Gavigan P,Hind W,Downer EJ

    更新日期:2020-06-15 00:00:00

  • Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis.

    abstract::G-protein-coupled receptors (GPCR) play an important role in inflammation. Their responsiveness is regulated by G-protein-coupled receptor kinases (GRKs) and beta-arrestins. We show here that induction of experimental autoimmune encephalomyelitis (EAE) by myelin oligodendrocyte glycoprotein (MOG) resulted in a profoun...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Vroon A,Lombardi MS,Kavelaars A,Heijnen CJ

    更新日期:2003-04-01 00:00:00