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CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats.

Abstract：

:The role of CD8⁺ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8⁺ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD8⁺ T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-γ-producing effector cells. Our results indicate that CD8⁺ T cells interact with myelin-specific CD8⁺ T cells early in EAE enabling them to differentiate into pathogenic effector cells.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Camara M,Beyersdorf N,Fischer HJ,Herold MJ,Ip CW,van den Brandt J,Toyka KV,Taurog JD,Hünig T,Herrmann T,Reichardt HM,Weishaupt A,Kerkau T

doi

10.1016/j.jneuroim.2013.04.014

subject

Has Abstract

pub_date

2013-07-15 00:00:00

pages

17-27

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00098-2

journal_volume

260

pub_type

杂志文章

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