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The T cell-selective IL-2 mutant AIC284 mediates protection in a rat model of Multiple Sclerosis.

Abstract：

:Targeting regulatory T cells (Treg cells) with interleukin-2 (IL-2) constitutes a novel therapeutic approach for autoimmunity. As anti-cancer therapy with IL-2 has revealed substantial toxicities a mutated human IL-2 molecule, termed AIC284 (formerly BAY 50-4798), has been developed to reduce these side effects. To assess whether AIC284 is efficacious in autoimmunity, we studied its therapeutic potential in an animal model for Multiple Sclerosis. Treatment of Lewis rats with AIC284 increased Treg cell numbers and protected the rats from Experimental Autoimmune Encephalomyelitis (EAE). AIC284 might, thus, also efficiently prevent progression of autoimmune diseases in humans.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Weishaupt A,Paulsen D,Werner S,Wolf N,Köllner G,Rübsamen-Schaeff H,Hünig T,Kerkau T,Beyersdorf N

doi

10.1016/j.jneuroim.2015.03.020

subject

Has Abstract

pub_date

2015-05-15 00:00:00

pages

63-72

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(15)00075-2

journal_volume

282

pub_type

杂志文章

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