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Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells.

Abstract：

:Inflammatory mediators have been proposed to play a critical role in the pathogenesis of choroidal neovascularization, a blinding complication of age-related macular degeneration. We evaluated the expression of TNF-alpha in human choroidal neovascular membranes and found that it colocalized with cells expressing VEGF, angiopoietin (Ang)-1 and Ang2. In cultured choroidal endothelial cells we found that TNF-alpha increased Ang2 mRNA (increased transcription) and protein levels prior to those of Ang1 and VEGF. The results raise the possibility that during neovascularization, TNF-alpha may modulate endothelial plasticity and survival by sequential inactivation of Tie2 followed by activation of Tie2 and VEGF receptors.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Hangai M,He S,Hoffmann S,Lim JI,Ryan SJ,Hinton DR

doi

10.1016/j.jneuroim.2005.09.018

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

45-56

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00419-4

journal_volume

171

pub_type

杂志文章

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