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Inhibition of naive Th1 CD4+ T cells by glatiramer acetate in multiple sclerosis.

Abstract：

:We investigated whether glatiramer acetate (GA) treatment may affect Th1 differentiation at various T-cell maturation stages. Specifically, we analyzed the effect of in vivo GA treatment on intracellular synthesis of IL-2 and TNF-alpha by naive, memory and effector CD4(+) and CD8(+) T cells by five-colour flow cytometry. Our data indicate that GA treatment downregulates/normalizes an accelerated Th1 differentiation of CD4(+) T cells in RRMS patients at all stages of T-cell maturation. Most notably, we conclude that, by altering naive, unprimed CD4(+) T cells, GA treatment appears to affect T-cell differentiation, at least in part, in an antigen-independent manner.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kantengwa S,Weber MS,Juillard C,Benkhoucha M,Fellay B,Zamvil SS,Gougeon ML,Chofflon M,Lalive PH

doi

10.1016/j.jneuroim.2006.12.014

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

123-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(07)00002-1

journal_volume

185

pub_type

杂志文章

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