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Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients.

Abstract：

:This study replicates and extends prior reports of abnormal cytokine levels in chronic pain patients and has correlated the alterations with pain severity. In addition, there appeared to be a need to directly assess cerebrospinal fluid (CSF) because previous findings on cytokine concentrations in peripheral circulation have been inconsistent. CSF and blood specimens were obtained from 14 patients with distal painful non-diabetic polyneuropathy (DPPN) or post-traumatic neuralgia (PTN). Elevated receptor levels for Tumor Necrosis Factor (sTNFr) were the most distinctive abnormality along with low interleukin-10 (IL-10). sTNFr in CSF and blood, and IL-1ss in CSF, were positively associated with pain intensity, whereas IL-10 in both compartments was inversely correlated with pain symptoms. An imbalance of pro- and anti-inflammatory cytokines appears to be a clinically relevant feature, which may contribute to the maintenance of chronic pain.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Backonja MM,Coe CL,Muller DA,Schell K

doi

10.1016/j.jneuroim.2008.01.005

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

157-63

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(08)00028-3

journal_volume

195

pub_type

杂志文章

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