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Pattern recognition receptor mRNA expression and cytokine and granzyme levels in HIV infected individuals with neurotuberculosis.

Abstract：

:Neurotuberculosis is one of the commonest HIV-associated opportunistic infections (OI) of the CNS. Cross-talk between HIV, Mycobacterium tuberculosis and host immune responses may alter expression of pattern recognition receptors (PRRs), thereby affecting cytokine profiles and functional responses. We examined PRR mRNA expression and cytokine and granzyme levels in HIV infected individuals with neurotuberculosis and found significant downregulation of TLR9 and increased MDA5 expression compared to healthy subjects. Significantly higher Granzyme A and IFN-γ levels were also observed in the CSF of this group compared to CSF from non-infectious controls. These alterations may lead to inappropriate recruitment of immune cells to the CNS, leading to disease severity.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Rao D,Vasanthapuram R,Satishchandra P,Desai A

doi

10.1016/j.jneuroim.2018.01.015

subject

Has Abstract

pub_date

2018-05-15 00:00:00

pages

21-28

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(17)30317-X

journal_volume

318

pub_type

杂志文章

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