当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses.

Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses.

Abstract：

:Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects. Here, we examined the effects of berberine on dopamine receptors and the ensuing anti-inflammatory responses. Berberine was found to be an antagonist at both dopamine D1- and D2-like receptors and ameliorates the development of experimentally induced colitis in mice. In lipopolysaccharide-stimulated immune cells, berberine treatment modified cytokine levels, consistent with the effects of the dopamine receptor specific antagonists SCH23390 and L750667. Our findings indicate that dopamine receptor antagonists suppress innate and adaptive immune responses, providing a foundation for their use in combatting inflammatory diseases.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kawano M,Takagi R,Kaneko A,Matsushita S

doi

10.1016/j.jneuroim.2015.10.001

subject

Has Abstract

pub_date

2015-12-15 00:00:00

pages

43-55

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(15)30047-3

journal_volume

289

pub_type

杂志文章

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