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Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system.

Abstract：

:Traumatic brain injury can lead to locally destructive secondary events mediated by several inflammatory components. Following lateral fluid-percussion (FP) brain injury in rats, we examined cortical and hippocampal sections for neutrophil infiltration and accumulation of complement component C3. Neutrophil influx into the brain after injury was detected by an improved myeloperoxidase (MPO) microassay and manual cell counting, while C3 accumulation was detected using immunocytochemistry. MPO levels were elevated in the injured cortical tissue, whereas C3 immunoreactivity was increased in both injured cortical and ipsilateral hippocampal sections. These results show that the FP model of head injury leads to an intense local inflammatory reaction and subsequent tissue destruction.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Keeling KL,Hicks RR,Mahesh J,Billings BB,Kotwal GJ

doi

10.1016/s0165-5728(00)00183-1

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

20-30

issue

1

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(00)00183-1

journal_volume

105

pub_type

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