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T cell vaccination does not induce resistance to experimental autoimmune neuritis.

Abstract：

:The effectiveness of T cell vaccination was analyzed in experimental autoimmune neuritis (EAN) that can be induced by immunization with bovine P2 protein or a peptide representing the amino acids 53-78 of P2 (P2 53-78). Lewis rats were vaccinated with glutaraldehyde-fixed lymph node cells which had been primed in vivo with P2 protein or P2 53-78 and had been activated in vitro with concanavalin A. Vaccinated animals were not protected from EAN induced by immunization with P2 protein in complete Freund's adjuvant (CFA). In a second set of experiments Lewis rats were vaccinated with irradiated or fixed P2-specific T cell lines of different specificity and neuritogenicity and were subsequently challenged with P2 53-78 in CFA. Likewise, severity of P2 53-78-induced EAN was not different between naive and T line-vaccinated groups. In spleens of vaccinated animals a substantial suppressive activity was demonstrated which was positively correlated with a weak anti-ergotypic response of these spleen cells. The fact that development of actively induced EAN was not prevented or even mitigated by T cell vaccination, in spite of an apparent vaccination-induced response to and on T lymphocytes, suggests that protection from disease is not readily induced in every autoimmune disease model.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Jung S,Schluesener HJ,Toyka K,Hartung HP

doi

10.1016/0165-5728(91)90156-2

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

1-11

issue

1-3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(91)90156-2

journal_volume

35

pub_type

杂志文章

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