Abstract:
:To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5 KO mice displayed intact secondary antibody and lymphoproliferative responses to acetylcholine receptor (AChR) after immunization with this molecule. However, the relative resistance of IL-5 KO mice was associated with a reduced primary lymphocyte response to AChR, and reduced C3 levels in muscle extracts compared to those in C57BL/6 mice.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Poussin MA,Goluszko E,Franco JU,Christadoss Pdoi
10.1016/s0165-5728(02)00030-9subject
Has Abstractpub_date
2002-04-01 00:00:00pages
51-8issue
1-2eissn
0165-5728issn
1872-8421pii
S0165572802000309journal_volume
125pub_type
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