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Increase of matrix metalloproteinase-9 in peripheral blood of multiple sclerosis patients treated with high doses of methylprednisolone.

Abstract：

:Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healthy controls. MMP-9 levels tended to be elevated. During therapy, MMP-9 levels demonstrate a dose-dependent increase. No effect was noted on TIMP-1 and MMP-2 levels. The short-lived increase of MMP-9 plasma levels may be at least in part due to an activation and an increase of granulocytes and monocytes by methylprednisolone.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

doi

10.1016/j.jneuroim.2003.10.046

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

171-5

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S016557280300465X

journal_volume

146

pub_type

临床试验,杂志文章,随机对照试验

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