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Substance P receptor expression on lymphocytes is associated with the immune response to respiratory syncytial virus infection.

Abstract：

:The kinetics and magnitude of SP receptor expression was determined for bronchoalveolar leukocyte cell subsets from BALB/c mice in the primary immune response to respiratory syncytial virus (RSV) and human parainfluenza virus-3 (PIV3) infection, and in the secondary immune response to RSV and PIV3 challenge. In both the primary and secondary responses to infection, expression of substance P (SP) receptors was markedly increased by infection, especially for T lymphocytes, compared to B220+, CD11b+ and CD14+ cells. CD4+ T lymphocytes predominantly expressed SP receptors in the secondary response. These results suggest that SP receptor expression may be important in the development of primary and secondary immune responses to respiratory virus infections.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Tripp RA,Barskey A,Goss L,Anderson LJ

doi

10.1016/s0165-5728(02)00169-8

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

141-53

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572802001698

journal_volume

129

pub_type

杂志文章

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