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Different content of chitin-like polysaccharides in multiple sclerosis and Alzheimer's disease brains.

Abstract：

:Chitin is an insoluble N-acetyl-glucosamine polymer coating fungi cell wall and several human parasites. It is hydrolysed by chitotriosidase (Chit); however, as chitin is absent in humans, the significance of human Chit activity is unknown. The level of plasma Chit activity positively correlates with Alzheimer's disease (AD) and multiple sclerosis (MS). A recent study revealed the presence of potentially detrimental chitin-like substances in AD brain by Calcofluor histochemistry, whilst its search in MS brains has never been described to date. Through a comparative immunohistochemical analysis we confirm the presence of abundant chitin-like deposition in AD brains but fail to demonstrate it in MS brains. Interestingly, co-localization of beta-amyloid, Calcofluor and the nuclear marker DAPI was observed. Therefore, Chit production in MS patients is induced by mechanisms other than those operating in AD. Microglia-derived Chit activity in MS may counterbalance the naturally occurring glucosamine aggregation, protecting the brain from the chitin-like substance deposition.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Sotgiu S,Musumeci S,Marconi S,Gini B,Bonetti B

doi

10.1016/j.jneuroim.2008.03.021

subject

Has Abstract

pub_date

2008-06-15 00:00:00

pages

70-3

issue

1

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(08)00087-8

journal_volume

197

pub_type

杂志文章

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