Augmented intrathecal secretion of interferon-gamma in response to Borrelia garinii in neuroborreliosis.

abstract：:The common acute lymphoblastic leukemia antigen (CALLA), CD10, is a 100-kDa surface glycoprotein endowed with neutral endopeptidase activity, shared by a number of hemopoietic and non-hemopoietic cells. In this report, immunohistochemical and Western blot techniques, using different anti-CD10 monoclonal antibodies, we...

journal_title：Journal of neuroimmunology

authors： Cadoni A,Mancardi GL,Zaccheo D,Nocera A,Barocci S,Bianchini D,Schenone A,Capello E,Zicca A

更新日期：1993-06-01 00:00:00

abstract：:Human Leukocyte Antigen G (HLA-G) gene polymorphism and expression rate have recently been suggested to have a potential role in susceptibility to Multiple Sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown etiology. The aim of this study was t...

journal_title：Journal of neuroimmunology

authors： Mohammadi N,Adib M,Alsahebfosoul F,Kazemi M,Etemadifar M

更新日期：2016-01-15 00:00:00

abstract：:A significant reduction in the incidence of experimental allergic encephalomyelitis (EAE) in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate. These results are discussed in terms of the selective in...

journal_title：Journal of neuroimmunology

authors： Inada T,Mims CA

更新日期：1986-03-01 00:00:00

abstract：:Endogenous hypothalamic pro-inflammatory cytokines modulate the hypothalamic-pituitary-adrenal (HPA) axis responses. To investigate whether hypothalamic IL-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) are associated with differential inflammatory susceptibilities between Lewis (LEW/N) and Fischer (F344/N) ...

journal_title：Journal of neuroimmunology

authors： Wei R,Listwak SJ,Sternberg EM

更新日期：2003-02-01 00:00:00

abstract：:The human platelet serotonergic responses of aggregation and uptake were shown to be modulated by muramyl peptides. Muramyl dipeptide inhibited serotonin uptake in a temperature dependent and stereospecific manner. It also blocked the binding to platelets of [3H]imipramine, a well-known inhibitor of serotonin uptake. ...

journal_title：Journal of neuroimmunology

authors： Polanski M,Karnovsky ML

更新日期：1992-03-01 00:00:00

abstract：:The aim of this study was to investigate the humoral immune response to Borna disease (BD) virus in the brain of experimentally infected Lewis rats. Abundant IgG was detected in BD-rat brain with isotype variation throughout infection. IgG was locally produced as indicated by an intact blood-brain barrier, Ig kappa li...

journal_title：Journal of neuroimmunology

authors： Hatalski CG,Hickey WF,Lipkin WI

更新日期：1998-10-01 00:00:00

abstract：:The objective of this study was to evaluate multiple interferon (IFN) specific mRNA biomarkers in multiple sclerosis (MS) patients with anti-IFN-beta neutralizing antibodies (NAB) using a pharmacodynamic study design. Thirty patients were enrolled. Blood samples were drawn at pre-treatment, 4-, 8-h time points followi...

journal_title：Journal of neuroimmunology

authors： Santos R,Weinstock-Guttman B,Tamaño-Blanco M,Badgett D,Zivadinov R,Justinger T,Munschauer F 3rd,Ramanathan M

更新日期：2006-07-01 00:00:00

abstract：:Toll-like receptors (TLRs) are sensors of pathogen-associated molecules that trigger inflammatory signalling in innate immune cells including macrophages. All TLRs, with the exception of TLR3, promote intracellular signalling via recruitment of the myeloid differentiation factor 88 (MyD88) adaptor, while TLR3 signals ...

journal_title：Journal of neuroimmunology

authors： Fitzpatrick JM,Minogue E,Curham L,Tyrrell H,Gavigan P,Hind W,Downer EJ

更新日期：2020-06-15 00:00:00

abstract：:The Th1-like cytokines, interleukin 2 (IL-2), interferon gamma (IFN-gamma), and lymphotoxin alpha (LT-alpha) have been implicated in the immunopathogenesis of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), an animal model of immune mediated demyelination. These cytokines have been associate...

journal_title：Journal of neuroimmunology

authors： Calabresi PA,Fields NS,Farnon EC,Frank JA,Bash CN,Kawanashi T,Maloni H,Jacobson S,McFarland HF

更新日期：1998-05-15 00:00:00

abstract：:A high proportion of peptide 1-11 specific T cells from H-2u (V beta 8+, H-2u) mice express the V beta 8 TCR chain. Peptide 89-101 is immunodominant for B10.RIII (V beta 8+, H-2r) mice; thus, it was of interest to determine whether V beta 8 TCR would be over-represented in a population of peptide 89-101-specific T cel...

journal_title：Journal of neuroimmunology

authors： Zhao ML,Xia JQ,Fritz RB

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Toll-like receptor 4(TLR4)/nuclear factor kappa B NF-κB inflammatory pathway contributes to secondary inflammation in many diseases including stroke. Moreover, the neuroprotective effect of splenectomy in stroke is supported by a vast body of experimental evidence. Nevertheless, the underlyin...

journal_title：Journal of neuroimmunology

authors： Belinga VF,Wu GJ,Yan FL,Limbenga EA

更新日期：2016-04-15 00:00:00

abstract：:Multiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS) in which autoreactive immune cells recognizing myelin antigens lead to demyelination and axonal injury. Mechanisms relevant to the pathogenesis of MS have not been fully elucidated, particularly those underlying initiation of ...

journal_title：Journal of neuroimmunology

authors： Selmaj I,Mycko MP,Raine CS,Selmaj KW

更新日期：2017-05-15 00:00:00

abstract：:Myasthenia gravis (MG) is a neuromuscular disease thought to have an autoimmune etiology. The acetylcholine receptor has been considered the primary site of antibody binding; however, other muscle components may be involved in the pathogenesis of myasthenia gravis. This study describes a hypertonic sucrose extract of ...

journal_title：Journal of neuroimmunology

authors： Mehl VS,Lang RW

更新日期：1984-08-01 00:00:00

abstract：:Migraine is believed to be a chronic neurological disorder with the exact aetiology being unknown. But, there is a debate on the role of immune dysfunction in migraine pathophysiology. Hence, authors made a debut attempt to explore the link between lymphocyte subset populations and migraine. A significant increase in ...

journal_title：Journal of neuroimmunology

authors： Arumugam M,Parthasarathy V

更新日期：2016-01-15 00:00:00

abstract：:Intrathecal Immunoglobulin G (IgG) is elevated in some central nervous system (CNS) diseases and microglia upregulate Fcγ receptors in various neurological disorders. However, the interaction between IgG or IgG immune complexes and microglial Fcγ receptors is not fully understood. In this study, the effect of IgG(1) i...

journal_title：Journal of neuroimmunology

authors： Parajuli B,Sonobe Y,Kawanokuchi J,Doi Y,Noda M,Takeuchi H,Mizuno T,Suzumura A

更新日期：2012-03-01 00:00:00

abstract：:We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-γ secreting cells following stimulation with autologous EBV-infected lymphobl...

journal_title：Journal of neuroimmunology

authors： Lindsey JW,Hatfield LM

更新日期：2010-12-15 00:00:00

abstract：:Stiff person spectrum disorders (SPSD) are a broad group of immune-mediated disorders. Clinical presentations include classical stiff person syndrome (SPS), focal SPS, and progressive encephalomyelitis with rigidity and myoclonus (PERM). The most frequently associated antibodies are anti-GAD65, anti-GlyR, anti-amphiph...

journal_title：Journal of neuroimmunology

authors： Bernardo F,Rebordão L,Rêgo A,Machado S,Passos J,Costa C,Cruz S,Pinto AN,Santos M

更新日期：2020-04-15 00:00:00

abstract：:Antigen presentation, a key mechanism in immune responses, involves two main signals: the first is provided by the engagement of a major histocompatibility complex (MHC), class I or class II, with their TCR receptor in lymphocytes, whereas the second demands the participation of different co-stimulatory molecules, suc...

journal_title：Journal of neuroimmunology

authors： Almolda B,González B,Castellano B

更新日期：2010-06-01 00:00:00

abstract：:The synthetic amino acid copolymer, copolymer 1 (Cop 1) induces T suppressor (Ts) lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein (MBP), but not with other myelin antigens on the level of Th2 cytokine secretion. Nevertheless, Cop 1 Ts cells inhibited the IL-2 response of a pr...

journal_title：Journal of neuroimmunology

authors： Aharoni R,Teitelbaum D,Sela M,Arnon R

更新日期：1998-11-02 00:00:00

abstract：:High concentrations of novel, haloperidol- and DTG-inaccessible (+)-[3H]-3-PPP binding sites were found in human peripheral blood leukocytes rat spleen and splenocytes, but not in rat brain. Splenic sites were localized in a course punctate pattern in the marginal zones and red pulp. The pharmacology of the splenic si...

journal_title：Journal of neuroimmunology

authors： Whitlock BB,Liu Y,Chang S,Saini P,Ha BK,Barrett TW,Wolfe SA Jr

更新日期：1996-07-01 00:00:00

abstract：:Methadone is known to exert modulatory effects on the immune system. We investigated the potential effects of methadone on infiltration of inflammatory cells into the spinal cord, as well as the proliferative and cytokine responses of T cells in MOG(35-55)-induced experimental autoimmune encephalomyelitis in mice. Met...

journal_title：Journal of neuroimmunology

authors： Kafami L,Etesami I,Felfeli M,Enayati N,Ghiaghi R,Aminian A,Dehpour A

更新日期：2013-02-15 00:00:00

abstract：:We investigated the role of intracerebroventricular (ICV) injection of rimonabant (500ng), a CB1 antagonist, on lipopolysaccharide ((LPS) 5mg/kg)-induced pulmonary inflammation in rats in an isolated perfused lung model. There were decreases in pulmonary capillary pressure (Ppc) and increases in the ((Wet-Dry)/Dry lun...

journal_title：Journal of neuroimmunology

authors： Johnson A,Neumann PH,Peng J,James J,Russo V,MacDonald H,Gertzberg N,Feleder C

更新日期：2015-09-15 00:00:00

abstract：:Resident glial cells and invading inflammatory cells are responsible for cytokine production within the brain. Astrocytes are known to secrete a variety of cytokines upon stimulation with cytokines themselves, protein kinase C activators, bacterial or viral constituents. Astrocytes also have surface receptors for a wi...

journal_title：Journal of neuroimmunology

authors： Maimone D,Cioni C,Rosa S,Macchia G,Aloisi F,Annunziata P

更新日期：1993-08-01 00:00:00

abstract：:Neuroadapted Sindbis virus infection of mice causes T cell-mediated fatal encephalomyelitis. In the absence of IL-10, pathogenic Th17 cells are increased and disease is accelerated. Lymphoid and myeloid cell contributions to IL-10 production were determined using VertX IL-10 transcriptional eGFP reporter mice. Effecto...

journal_title：Journal of neuroimmunology

authors： Kulcsar KA,Griffin DE

更新日期：2016-06-15 00:00:00

abstract：:We previously reported that interleukin-4 (IL-4) inhibited proliferation of a human astrocytic cell line derived from non-neoplastic adult cortex. To determine whether this effect was receptor-associated and/or limited to only non-neoplastic astrocytes, we examined IL-4 responsiveness and receptor expression in human ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Estes ML,Pettay J,Iwasaki K,Zhou P,Barnett GH

更新日期：1995-07-01 00:00:00

abstract：:beta-Endorphin 1-31 and several structurally related peptides were tested for their ability to alter mitogen-induced T cell proliferation. Rat beta-endorphin 1-31 and human beta-endorphin 1-27 increased phytohemagglutinin (PHA)-induced [3H]thymidine incorporation into rat lymph node cells. However, when PHA-induced pr...

journal_title：Journal of neuroimmunology

authors： Hemmick LM,Bidlack JM

更新日期：1990-09-01 00:00:00

abstract：:B lymphocytes play an important role in the pathogenesis of multiple sclerosis (MS). Follicle-like structures (FLS) have recently been found in the subarachnoid space in the leptomeninges in some patients with secondary progressive MS (SPMS). They contain proliferating B lymphocytes, plasma cells, helper T lymphocytes...

journal_title：Journal of neuroimmunology

authors： Haugen M,Frederiksen JL,Degn M

更新日期：2014-08-15 00:00:00

abstract：:Tissue cysts, the hallmark of chronic Toxoplasma gondii infection, are predominantly located in the brain making clearance of the parasite difficult. Currently available anti-T. gondii drugs are ineffective on cysts and fail to prevent reactivation of latent toxoplasmosis. We examined whether abrogation of inhibitory ...

journal_title：Journal of neuroimmunology

authors： Xiao J,Li Y,Yolken RH,Viscidi RP

更新日期：2018-06-15 00:00:00

abstract：:This study replicates and extends prior reports of abnormal cytokine levels in chronic pain patients and has correlated the alterations with pain severity. In addition, there appeared to be a need to directly assess cerebrospinal fluid (CSF) because previous findings on cytokine concentrations in peripheral circulatio...

journal_title：Journal of neuroimmunology

authors： Backonja MM,Coe CL,Muller DA,Schell K

更新日期：2008-03-01 00:00:00

abstract：:We analyzed the relationship between the expression of interferon (IFN)-gamma and HTLV-I p19 antigen and activation of p38 mitogen-activated protein kinase (p38 MAPK) in two HTLV-I-infected T cell lines derived from two patients (HCT-1 and HCT-4) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...

journal_title：Journal of neuroimmunology

authors： Fukushima N,Nishiura Y,Nakamura T,Yamada Y,Kohno S,Eguchi K

更新日期：2005-02-01 00:00:00