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Initial characterization and autoradiographic localization of a novel sigma/opioid binding site in immune tissues.

Abstract：

:High concentrations of novel, haloperidol- and DTG-inaccessible (+)-[3H]-3-PPP binding sites were found in human peripheral blood leukocytes rat spleen and splenocytes, but not in rat brain. Splenic sites were localized in a course punctate pattern in the marginal zones and red pulp. The pharmacology of the splenic sites was: (-)-SKF 10,047 > or = naltrexone = (-)-pentazocine > (+)-pentazocine = (-)-3-PPP = (+)-SKF 10,047 > or = (+)-3-PPP > or = dextrorphan > dextromethorphan > PCP > clorgyline. DTG, haloperidol, TCP, (-)-deprenyl and SKF 525-A did not complete. Binding activity was destroyed by heating and phospholipase C, but not by proteases or glycosidases. These sites may be involved in immunomodulation by opiate and sigma receptor agonists.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Whitlock BB,Liu Y,Chang S,Saini P,Ha BK,Barrett TW,Wolfe SA Jr

doi

10.1016/0165-5728(96)00041-0

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

83-96

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165572896000410

journal_volume

67

pub_type

杂志文章

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