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alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain.

Abstract：

:The purpose of this study was to determine if alpha-tocopherol-a reactive oxygen species (ROS) scavenging agent-inhibits LPS-induced oxidative stress and interleukin-6 (IL-6) production in murine microglia and brain. LPS increased intracellular peroxides and IL-6 in a dose-dependent fashion in primary microglia. The LPS-induced increase in ROS and IL-6 was reduced by pretreatment of alpha-tocopherol. Intraperitoneal injection (i.p.) of LPS induced lipid peroxidation and IL-6 in brain. Importantly, three daily injections (20 mg) of alpha-tocopherol increased brain alpha-tocopherol and decreased LPS-induced lipid peroxidation and IL-6 in brain. Taken together, these data indicate that alpha-tocopherol can mitigate inflammatory cytokine production in the brain.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Godbout JP,Berg BM,Kelley KW,Johnson RW

doi

10.1016/j.jneuroim.2003.12.017

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

101-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572803005733

journal_volume

149

pub_type

杂志文章

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