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Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients.

Abstract：

:Interferon-beta (IFN-beta) achieves its beneficial effect on multiple sclerosis (MS) via anti-inflammatory properties. In this study, we assessed the expression of the brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear cells (PBMC) from relapsing-remitting multiple sclerosis (RRMS) patients treated or not with IFN-beta. Intracellular BDNF was measured by Western blot and ELISA and compared with serum BDNF. We found higher levels of BDNF in PBMC of IFN-beta-treated versus non-treated patients, whereas serum levels of BDNF were similar. We hypothesize that the increased intracellular BDNF secondary to IFN-beta is not released in the periphery. This release is probably not tissue specific but in MS patients, BDNF could be specifically delivered by PBMC at the site of re-activation, i.e. within the central nervous system.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Lalive PH,Kantengwa S,Benkhoucha M,Juillard C,Chofflon M

doi

10.1016/j.jneuroim.2008.04.033

subject

Has Abstract

pub_date

2008-07-15 00:00:00

pages

147-51

issue

2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(08)00130-6

journal_volume

197

pub_type

杂志文章

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