当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice.

Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice.

Abstract：

:Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared to wild-type animals. Enhanced microglial cell activation, determined by MHC class II up-regulation, overexpression of CXCL2, and elevated P-selectin mRNA levels were observed. In vivo blocking of CXCL2 attenuated neutrophil infiltration and significantly improved the outcome of infection. Collectively, these data indicate that the absence of IL-10 results in pathologic neutrophil infiltration into MCMV-infected brains.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Mutnal MB,Cheeran MC,Hu S,Little MR,Lokensgard JR

doi

10.1016/j.jneuroim.2010.06.020

subject

Has Abstract

pub_date

2010-10-08 00:00:00

pages

101-10

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(10)00287-0

journal_volume

227

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1 beta and TNF alpha.

    abstract：:Resident glial cells and invading inflammatory cells are responsible for cytokine production within the brain. Astrocytes are known to secrete a variety of cytokines upon stimulation with cytokines themselves, protein kinase C activators, bacterial or viral constituents. Astrocytes also have surface receptors for a wi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90286-8

    authors： Maimone D,Cioni C,Rosa S,Macchia G,Aloisi F,Annunziata P

    更新日期：1993-08-01 00:00:00

  • The importance of being receptive.

    abstract：:Neuroendocrine system and immune system can communicate via the use of soluble mediators like hormones, neurotransmitters and cytokines. The level of mediators secreted by either of these systems creates the milieu in which immune and neuroendocrine responses take place. For adequate communication between the systems,...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0165-5728(99)00194-0

    authors： Heijnen CJ,Kavelaars A

    更新日期：1999-12-01 00:00:00

  • Costimulatory molecules B7-1 and B7-2 on CSF cells in multiple sclerosis and optic neuritis.

    abstract：:The aberrant expression of B7 costimulatory molecules is involved in the pathogenesis of autoimmune diseases and overexpression of B7-1 was found in inflammatory multiple sclerosis (MS) lesions. We here report that costimulatory molecules B7-1 and B7-2 are expressed on cerebrospinal fluid (CSF) monocytes and B-lymphoc...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(99)00012-0

    authors： Windhagen A,Maniak S,Gebert A,Ferger I,Heidenreich F

    更新日期：1999-04-01 00:00:00

  • Prevention of murine experimental allergic encephalomyelitis: cooperative effects of cyclosporine and 1 alpha, 25-(OH)2D3.

    abstract：:The hormone 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) has immune modulatory activities in vitro and in vivo, and can prevent or delay the onset of experimental or spontaneous autoimmune diseases. At therapeutical doses, however, hypercalcemic side effects are found. The present experiments examined the effects of ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(95)00076-e

    authors： Branisteanu DD,Waer M,Sobis H,Marcelis S,Vandeputte M,Bouillon R

    更新日期：1995-09-01 00:00:00

  • Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients.

    abstract：:Interferon-beta (IFN-beta) achieves its beneficial effect on multiple sclerosis (MS) via anti-inflammatory properties. In this study, we assessed the expression of the brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear cells (PBMC) from relapsing-remitting multiple sclerosis (RRMS) patients treat...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2008.04.033

    authors： Lalive PH,Kantengwa S,Benkhoucha M,Juillard C,Chofflon M

    更新日期：2008-07-15 00:00:00

  • Evidence for genetic contamination of inbred buffalo rats (RT-1b) obtained from a commercial vendor.

    abstract：:Inbred Buffalo rats (RT-1b) have been used in studies of experimental autoimmune encephalomyelitis and autoimmune thyroiditis. Since our studies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain-dependent, allotype-specific variants ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90115-5

    authors： Jones RE,Weinberg A,Bourdette D

    更新日期：1994-07-01 00:00:00

  • Fluctuation of HTLV-I proviral DNA in peripheral blood mononuclear cells of HTLV-I-associated myelopathy.

    abstract：:To assess the immunopathological significance of the increased replication of human T-cell leukemia virus type I (HTLV-I) in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) we investigated the dynamics of HTLV-I proviral DNA in peripheral blood mononuclear cells (PBMC) of HAM/TSP patients at differ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90004-i

    authors： Kubota R,Fujiyoshi T,Izumo S,Yashiki S,Maruyama I,Osame M,Sonoda S

    更新日期：1993-02-01 00:00:00

  • Polyneuropathy with anti-sulfatide and anti-MAG antibodies: clinical, neurophysiological, pathological features and response to treatment.

    abstract：:IgM paraproteins often present reactivity to myelin-associated glycoprotein (MAG) and sulfatide. We describe the clinical and neurophysiological findings, and therapy response in 21 patients with IgM paraproteinemic neuropathy (15 with anti-MAG antibodies, 1 with anti-sulfatide antibodies, and 5 with both reactivity),...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.02.009

    authors： Campagnolo M,Ferrari S,Dalla Torre C,Cabrini I,Cacciavillani M,Lucchetta M,Ruggero S,Toffanin E,Cavallaro T,Briani C

    更新日期：2015-04-15 00:00:00

  • A monoclonal antibody recognizing subpopulations of neurones in mouse brain.

    abstract：:A monoclonal antibody, designated C138, was raised against a particulate fraction from young postnatal mouse cerebellum. In sections from adult mouse brain and cerebellum, this antibody stained a sub-population of neurons. Cell bodies of large neurones and fibre tracts were negative in all brain regions examined, wher...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(83)90034-6

    authors： Hirsch MR,Langley OK,Ghandour MS,Hirn M,Gombos G,Goridis C

    更新日期：1983-06-01 00:00:00

  • A novel soluble brain-specific protein (Sy-1). Identification and partial characterization.

    abstract：:A novel brain-specific antigen, called Sy-1, has been identified in whole rat brain hypotonic extracts by means of an antiserum produced in rabbits against the synaptosomal cytosol. Sy-1 is an acidic protein (pI 4.7) present exclusively in a soluble form and it does not carry any sugar moiety. Sy-1 is found only in ra...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(83)90012-7

    authors： Gennarini G,Corsi P,Pavia R,Vitiello F,Di Benedetta C

    更新日期：1983-04-01 00:00:00

  • Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity.

    abstract：:Muscle weakness in MuSK myasthenia gravis (MG) is caused predominantly by IgG4 antibodies which block MuSK signalling and destabilize neuromuscular junctions. We determined whether the binding pattern of MuSK IgG4 antibodies change throughout the disease course ("epitope spreading"), and affect disease severity or tre...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.12.016

    authors： Huijbers MG,Vink AF,Niks EH,Westhuis RH,van Zwet EW,de Meel RH,Rojas-García R,Díaz-Manera J,Kuks JB,Klooster R,Straasheijm K,Evoli A,Illa I,van der Maarel SM,Verschuuren JJ

    更新日期：2016-02-15 00:00:00

  • Immune function alterations in mice tolerant to delta9-tetrahydrocannabinol: functional and biochemical parameters.

    abstract：:We studied the effect of acute (1 h) or chronic exposure (7 and 14 days) to delta9-tetrahydrocannabinol (delta9-THC) on immune parameters in male Swiss mice. One hour after a dose of 10 mg/kg s.c., the splenocyte proliferative response to ConA and NK activity were not inhibited, but there was a significant decrease in...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00177-5

    authors： Massi P,Sacerdote P,Ponti W,Fuzio D,Manfredi B,Viganó D,Rubino T,Bardotti M,Parolaro D

    更新日期：1998-12-01 00:00:00

  • Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis.

    abstract：:In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched h...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.10.004

    authors： Plantone D,Marti A,Frisullo G,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Mirabella M,Batocchi AP

    更新日期：2013-12-15 00:00:00

  • Glial transforming growth factor (TGF)-beta isotypes in multiple sclerosis: differential glial expression of TGF-beta 1, 2 and 3 isotypes in multiple sclerosis.

    abstract：:We studied glial transforming growth factor (TGF)-beta isotype expression in 14 cases of multiple sclerosis. Acute active lesions exhibited selective TGF-beta 2 immunoreactivity of lesion encircling ramified microglia. In contrast, astrocytes within chronic active white matter lesions expressed all three isotypes. Chr...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(96)00135-x

    authors： Peress NS,Perillo E,Seidman RJ

    更新日期：1996-12-01 00:00:00

  • Increase of matrix metalloproteinase-9 in peripheral blood of multiple sclerosis patients treated with high doses of methylprednisolone.

    abstract：:Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healt...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jneuroim.2003.10.046

    authors： Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

    更新日期：2004-01-01 00:00:00

  • Comparative binding of murine and human monoclonal antibodies reacting with myelin-associated glycoprotein to myelin and human lymphocytes.

    abstract：:Human monoclonal IgM antibodies present in the blood of some patients with peripheral neuropathy and murine hybrid IgM antibodies C5 and C6, raised against myelin-associated glycoprotein, and HNK-1, raised against the human T cell line HSB-2, all bind to the carbohydrate moiety of myelin-associated glycoprotein. The r...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(87)90118-4

    authors： Miller SL,Kahn SN,Perussia B,Trinchieri G

    更新日期：1987-07-01 00:00:00

  • Effect of rhTNF-alpha injection into rat sciatic nerve.

    abstract：:To assess whether TNF-alpha causes inflammatory demyelination or axonal degeneration, we injected into rat sciatic nerve saline, 100 U and 1000 U of rhTNF-alpha and studied the electrophysiological and pathological effects. At day 1 electrophysiology showed a slight reduction of proximal compound muscle action potenti...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00229-x

    authors： Uncini A,Di Muzio A,Di Guglielmo G,De Angelis MV,De Luca G,Lugaresi A,Gambi D

    更新日期：1999-02-01 00:00:00

  • Phenotypes and alloantigen-presenting activity of individual clones of microglia derived from the mouse brain.

    abstract：:To clarify the origin and function of the microglia residing in the central nervous system, we cloned brain cells from newborn and adult mice in soft agar containing the macrophage-specific growth factor, colony-stimulating factor-1 and expanded the cells from individual colonies in liquid culture medium. The results ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90071-r

    authors： Moore SC,McCormack JM,Armendariz E,Gatewood J,Walker WS

    更新日期：1992-12-01 00:00:00

  • Neurologic disorders associated with anti-glutamic acid decarboxylase antibodies: A comparison of anti-GAD antibody titers and time-dependent changes between neurologic disease and type I diabetes mellitus.

    abstract：:To determine clinical features of neurologic disorders associated with anti-glutamic acid decarboxylase antibodies (anti-GAD-Ab), we examined titers and time-dependent changes of anti-GAD-Ab. Six patients, stiff person syndrome (2), cerebellar ataxia (1), limbic encephalitis (1), epilepsy (1), brainstem encephalitis (...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.01.007

    authors： Nakajima H,Nakamura Y,Inaba Y,Tsutsumi C,Unoda K,Hosokawa T,Kimura F,Hanafusa T,Date M,Kitaoka H

    更新日期：2018-04-15 00:00:00

  • Pancreatic ductal cell antigens are important in the development of invasive insulitis in Non-Obese Diabetic mice.

    abstract：:Type 1 Diabetes (T1D) is an autoimmune disease in which insulin producing beta cells of the pancreas are selectively destroyed. Glial Fibrillary Acidic Protein (GFAP) expressed in peri-islet Schwann cells (pSCs) and in the ductal cells of the pancreas is one of the candidate autoantigens for T1D. Immune responses to G...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2019.01.001

    authors： Jayasimhan A,Ellis DP,Ziegler AI,Slattery RM

    更新日期：2019-02-15 00:00:00

  • Inhibition of naive Th1 CD4+ T cells by glatiramer acetate in multiple sclerosis.

    abstract：:We investigated whether glatiramer acetate (GA) treatment may affect Th1 differentiation at various T-cell maturation stages. Specifically, we analyzed the effect of in vivo GA treatment on intracellular synthesis of IL-2 and TNF-alpha by naive, memory and effector CD4(+) and CD8(+) T cells by five-colour flow cytomet...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.12.014

    authors： Kantengwa S,Weber MS,Juillard C,Benkhoucha M,Fellay B,Zamvil SS,Gougeon ML,Chofflon M,Lalive PH

    更新日期：2007-04-01 00:00:00

  • Augmented intrathecal secretion of interferon-gamma in response to Borrelia garinii in neuroborreliosis.

    abstract：:The Lyme disease agent Borrelia garinii has been suggested to be neurotrop, preferentially affecting the nervous system. We compared the secretion of interferon-gamma in response to outer surface proteins from Borrelia garinii and Borrelia afzelii in 10 patients with neuroborreliosis. In cerebrospinal fluid, stimulati...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00136-2

    authors： Ekerfelt C,Ernerudh J,Forsberg P,Bergström S

    更新日期：1998-08-14 00:00:00

  • Autoantibody repertoires to brain tissue in autism nuclear families.

    abstract：:The hypothesis of an immune dysfunction in autism spectrum disorders has previously been put forward without, however, compelling evidence of a direct relation to its etiology or pathogenesis. To further understand if autoimmunity could play a significant role in autism, we analyzed autoantibody repertoires to brain t...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.03.015

    authors： Silva SC,Correia C,Fesel C,Barreto M,Coutinho AM,Marques C,Miguel TS,Ataide A,Bento C,Borges L,Oliveira G,Vicente AM

    更新日期：2004-07-01 00:00:00

  • Central nervous system infection and immune response in mice inoculated into the lip with herpes simplex virus type 1.

    abstract：:Virus may be recovered from various areas of the central nervous system (CNS) of mice for as long as 11 days after inoculation of herpes simplex virus type 1 (HSV-1) into the lip. The probability of isolation from any particular region of the CNS seems to be a function of the distance of that area from the root-entry ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(82)90062-5

    authors： Kastrukoff L,Hamada T,Schumacher U,Long C,Doherty PC,Koprowski H

    更新日期：1982-06-01 00:00:00

  • Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins.

    abstract：:Lymphocytic choriomeningitis virus (LCMV) induces a chronic, wasting syndrome when injected intracerebrally into H-2b mice homozygous for a beta 2-microglobulin (beta 2-m (-/-)) gene disruption. These mice have very few CD8+ T cells and express little class I MHC glycoprotein, though minimal levels of the H-2Db molecu...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90228-q

    authors： Doherty PC,Hou S,Southern PJ

    更新日期：1993-07-01 00:00:00

  • CD44 splice variant involvement in the chronic inflammatory disease of the spinal cord: HAM/TSP.

    abstract：:Splice variants of CD44 molecule-harboring exon 10 (v6), often called v6 variants (v6v), are shown to confer tumor progressive, metastatic or invasive capacities. Furthermore, CD44 molecule on activated T-cells are shown to be required for infiltration of these cells into the inflammatory site and for accelerated immu...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(99)00155-1

    authors： Matsuoka E,Usuku K,Jonosono M,Takenouchi N,Izumo S,Osame M

    更新日期：2000-01-03 00:00:00

  • Specific immunotherapy of experimental myasthenia gravis in vitro and in vivo: the Guided Missile strategy.

    abstract：:Current immunotherapy of myasthenia gravis (MG) is often effective, but entails risks of infection and neoplasia. The "Guided Missile" strategy described here is designed to target and eliminate the individual's unique AChR-specific T cell repertoire, without otherwise interfering with the immune system. We geneticall...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2012.06.007

    authors： Sun W,Adams RN,Miagkov A,Lu Y,Juon HS,Drachman DB

    更新日期：2012-10-15 00:00:00

  • Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection.

    abstract：:Viral infections of the central nervous system (CNS) are often associated with blood-brain barrier (BBB) disruption, yet the impact of virus replication and immune cell recruitment on BBB integrity are incompletely understood. Using two-photon microscopy, we demonstrate that Venezuelan equine encephalitis virus (VEEV)...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.04.008

    authors： Cain MD,Salimi H,Gong Y,Yang L,Hamilton SL,Heffernan JR,Hou J,Miller MJ,Klein RS

    更新日期：2017-07-15 00:00:00

  • Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis.

    abstract：:Apolipoprotein E (ApoE) functions as a ligand in receptor-mediated endocytosis of lipoprotein particles and has been demonstrated to play a role in antigen presentation. To explore the contribution of ApoE during autoimmune central nervous system (CNS) demyelination, we examined the clinical, cellular immune function,...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2014.03.010

    authors： Shin S,Walz KA,Archambault AS,Sim J,Bollman BP,Koenigsknecht-Talboo J,Cross AH,Holtzman DM,Wu GF

    更新日期：2014-06-15 00:00:00

  • Invariant NKT cells in adrenoleukodystrophy patients and mice.

    abstract：:X-linked adrenoleukodystrophy (X-ALD) is a severe neurological disease characterized by progressive demyelination within the CNS, adrenal insufficiency, and is associated with an accumulation of saturated very long chain fatty acids in plasma and tissues of patients. iNKT cells, a distinct lineage of T cells recognizi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.09.003

    authors： Gautron AS,Giquel B,Beaudoin L,Autrusseau E,Speak A,Platt F,Kemp S,Pujol A,Aubourg P,Lehuen A

    更新日期：2010-12-15 00:00:00