当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Pancreatic ductal cell antigens are important in the development of invasive insulitis in Non-Obese Diabetic mice.

Pancreatic ductal cell antigens are important in the development of invasive insulitis in Non-Obese Diabetic mice.

Abstract：

:Type 1 Diabetes (T1D) is an autoimmune disease in which insulin producing beta cells of the pancreas are selectively destroyed. Glial Fibrillary Acidic Protein (GFAP) expressed in peri-islet Schwann cells (pSCs) and in the ductal cells of the pancreas is one of the candidate autoantigens for T1D. Immune responses to GFAP expressing cell types precede the islet autoimmunity in Non-Obese Diabetic (NOD) mice. By removing MHC class I from GFAP expressing cell types, we tested the role of autoantigens presented by these cell types in the development of invasive insulitis. Our findings indicate that antigens expressed by pancreatic ductal cells are important in the development of invasive insulitis in NOD mice.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Jayasimhan A,Ellis DP,Ziegler AI,Slattery RM

doi

10.1016/j.jneuroim.2019.01.001

subject

Has Abstract

pub_date

2019-02-15 00:00:00

pages

1-9

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(18)30263-7

journal_volume

327

pub_type

杂志文章

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