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MicroRNA expression profiling in Guillain-Barré syndrome.

Abstract：

:Guillain-Barré syndrome (GBS) is an acute inflammatory autoimmune disease affecting the peripheral nervous system. MicroRNAs (miRNAs) are a class of small noncoding RNAs that play critical roles in the process of various diseases. The miRNAs in GBS were less studied. In this study, using microarray technology, we found two miRNAs including has-miR-4717-5p and has-miR-642b-5p were upregulated in patients with GBS, which were further confirmed by PCR analysis. Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that the dysregulated miRNAs may be involved in the mechanism of GBS by affecting the cellular differentiation, cell survival and axonal outgrowth.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Lv Z,Shi Q,Huang W,Xing C,Hao Y,Feng X,Yang Y,Zhang A,Kong Q,Yuki N,Wang Y

doi

10.1016/j.jneuroim.2016.10.014

subject

Has Abstract

pub_date

2016-12-15 00:00:00

pages

12-15

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(16)30374-5

journal_volume

301

pub_type

杂志文章

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