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Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-alpha and blood-brain barrier damage.

Abstract：

:The mechanism for the initiation of blood-brain barrier damage and intrathecal inflammation in multiple sclerosis (MS) is poorly understood. We have recently reported that levels of tumor necrosis factor-alpha (TNF-alpha) correlate with blood-brain barrier damage in patients with active MS. Stimulation of endothelial cells by TNF-alpha induces the expression of intercellular adhesion molecule-1 (ICAM-1), which is an important early marker of immune activation and response. We report herein for the first time the detection of high levels of free circulating ICAM-1 in serum and cerebrospinal fluid of patients with active MS. Levels of circulating ICAM-1 in these patients correlated with CSF pleocytosis, TNF-alpha levels and blood-brain barrier damage. These findings have important implications for the understanding and investigation of the intrathecal inflammatory response in active MS.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Sharief MK,Noori MA,Ciardi M,Cirelli A,Thompson EJ

doi

10.1016/0165-5728(93)90070-f

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

15-21

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

0165-5728(93)90070-F

journal_volume

43

pub_type

杂志文章

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