Abstract:
:Virus may be recovered from various areas of the central nervous system (CNS) of mice for as long as 11 days after inoculation of herpes simplex virus type 1 (HSV-1) into the lip. The probability of isolation from any particular region of the CNS seems to be a function of the distance of that area from the root-entry zone of the trigeminal nerve. It is also mouse strain-dependent, with much more extensive evidence of brain infection being found in BALB/c and C3H rather than C57BL/6 mice, in which it is limited to the pons. The virus could not be isolated from the CNS of BALB/c mice after 10 days, though HSV-1 is readily recovered from the trigeminal ganglia at least through day 38. Significant concentrations of HSV-1-specific immunoglobulin (Ig) were demonstrated consistently in cerebrospinal fluid (CSF) from day 12 after exposure to virus. The persistence of relatively high concentrations of IgM in the CSF indicates that much of this antibody may be synthesized locally in the brain.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Kastrukoff L,Hamada T,Schumacher U,Long C,Doherty PC,Koprowski Hdoi
10.1016/0165-5728(82)90062-5subject
Has Abstractpub_date
1982-06-01 00:00:00pages
295-305issue
3-4eissn
0165-5728issn
1872-8421pii
0165-5728(82)90062-5journal_volume
2pub_type
杂志文章abstract::Depending on the duration and severity, psychological tension and physical stress can enhance or suppress the immune system in both humans and animals. Although it has been established that chronic stress exerts a significant suppressive effect on immune function, the mechanisms by which affects immune responses remai...
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