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The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells.

Abstract：

:Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multiple sclerosis (MS) therapy. Here, we studied the immunomodulatory effects of HGF on DCs derived from human monocytes. DCs differentiated in the presence of HGF adopt a protolerogenic phenotype with increased ability to generate regulatory T cells, a property that might be exploited therapeutically in T cell-mediated immune disorders such as MS.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Molnarfi N,Benkhoucha M,Juillard C,Bjarnadóttir K,Lalive PH

doi

10.1016/j.jneuroim.2013.12.004

subject

Has Abstract

pub_date

2014-02-15 00:00:00

pages

105-10

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00335-4

journal_volume

267

pub_type

杂志文章

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