Prednisone and plasma exchange improve suppressor cell function in chronic inflammatory demyelinating polyneuropathy.

abstract：:The aim of this study was to evaluate a possible role of soluble CD14 (sCD14) in multiple sclerosis (MS). We found that sCD14 serum levels measured by ELISA were higher in MS patients compared to neurological and healthy controls. Within the MS group sCD14 levels were increased in relapsing-remitting and secondary pro...

journal_title：Journal of neuroimmunology

authors： Lutterotti A,Kuenz B,Gredler V,Khalil M,Ehling R,Gneiss C,Egg R,Deisenhammer F,Berger T,Reindl M

更新日期：2006-12-01 00:00:00

abstract：:High concentrations of novel, haloperidol- and DTG-inaccessible (+)-[3H]-3-PPP binding sites were found in human peripheral blood leukocytes rat spleen and splenocytes, but not in rat brain. Splenic sites were localized in a course punctate pattern in the marginal zones and red pulp. The pharmacology of the splenic si...

journal_title：Journal of neuroimmunology

authors： Whitlock BB,Liu Y,Chang S,Saini P,Ha BK,Barrett TW,Wolfe SA Jr

更新日期：1996-07-01 00:00:00

abstract：:Clinical and experimental studies with LPS injection have shown an increase in vasopressin (AVP) secretion in the early phase of severe sepsis, which is subsequently reduced despite persistent hypotension. The aim of this study was to evaluate the role of inducible nitric oxide synthase (iNOS)-derived NO in hypothalam...

journal_title：Journal of neuroimmunology

authors： Corrêa PB,Pancoto JA,de Oliveira-Pelegrin GR,Cárnio EC,Rocha MJ

更新日期：2007-02-01 00:00:00

abstract：:Stroke is the leading cause of death and the main cause of disability in surviving patients. The detrimental interaction between immune cells, glial cells, and matrix components in stroke pathology results in persistent inflammation that progresses to fibrosis. A substantial effort is being directed toward understandi...

journal_title：Journal of neuroimmunology

authors： Amruta N,Rahman AA,Pinteaux E,Bix G

更新日期：2020-07-09 00:00:00

abstract：:An increased proportion of citrullinated MBP (MBP-C8) occurs in the brains of multiple sclerosis (MS) patients. In this study, MBP-C8 from guinea pig (GP) brains was isolated and found encephalitogenic in Lewis rats upon immunization. An encephalitogenic T cell line selected with MBP-C8 preferentially reacted with MBP...

journal_title：Journal of neuroimmunology

authors： Cao L,Sun D,Whitaker JN

更新日期：1998-08-01 00:00:00

abstract：:Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses and the underlying mechanisms in response to metformin in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Metformin reduc...

journal_title：Journal of neuroimmunology

authors： Sun Y,Tian T,Gao J,Liu X,Hou H,Cao R,Li B,Quan M,Guo L

更新日期：2016-03-15 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a su...

journal_title：Journal of neuroimmunology

authors： Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S

更新日期：2006-07-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a common animal model that has the same pathology and pathogenesis as multiple sclerosis (MS). Dendritic cells (DCs) exert an important role in central and peripheral tolerance. DCs not only drive T cell priming and differentiation via playing antigen presentation fun...

journal_title：Journal of neuroimmunology

authors： Cao Q,Zheng C,Xie Z,Liu L,Zhu J,Jin T

更新日期：2020-01-15 00:00:00

abstract：:Natural killer (NK) cells from paired CSF and blood samples of patients with multiple sclerosis (MS), other neuroinflammatory diseases (IND), and non-inflammatory neurological diseases (NIND) were characterized using flow cytometry. NK cell frequency in CSF was overall decreased compared to blood, particularly in MS p...

journal_title：Journal of neuroimmunology

authors： Hamann I,Dörr J,Glumm R,Chanvillard C,Janssen A,Millward JM,Paul F,Ransohoff RM,Infante-Duarte C

更新日期：2013-01-15 00:00:00

abstract：:The expression of class I major histocompatibility complex (MHC) mRNA was compared in the brains of inflammatory susceptible, hypothalamic-pituitary-adrenal (HPA)-axis blunted Lewis rats and inflammatory resistant, HPA-axis hyperresponsive Fischer rats by quantitative in situ hybridization following lipopolysaccharide...

journal_title：Journal of neuroimmunology

authors： Puchowicz M,Tonelli LH,Sternberg EM

更新日期：2003-01-01 00:00:00

abstract：:To explore the possible contribution of thymic myoid cells in tolerance induction mechanisms, we quantified by real-time RT-PCR, the expression of 12 muscle genes (the five subunits of acetylcholine receptor, Musk, rapsyn, utrophin, ErbB2, ErbB3, troponin T, and MCK) in a human thymic myoid cell line (MITC), compared ...

journal_title：Journal of neuroimmunology

authors： Mesnard-Rouiller L,Bismuth J,Wakkach A,Poëa-Guyon S,Berrih-Aknin S

更新日期：2004-03-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN), an autoimmune inflammatory demyelinating disease of the peripheral nervous system, represents an animal model of the human Guillain-Barré syndrome. EAN can be induced by active immunization in several animals, including Lewis rats. In contrast, most strains of mice including the...

journal_title：Journal of neuroimmunology

authors： Zhu J,Zou L,Zhu S,Mix E,Shi F,Wang H,Volkmann I,Winblad B,Schalling M,Ljunggren H

更新日期：2001-04-02 00:00:00

abstract：:Previously, our laboratory showed that either abrupt (AW) or precipitated withdrawal (PW) from morphine led to profound suppression of murine splenic antibody responses to sheep red blood cells at 24 h post-withdrawal. In the present studies, we examined the immune mechanisms mediating suppression at that time point. ...

journal_title：Journal of neuroimmunology

authors： Rahim RT,Feng P,Meissler JJ,Rogers TJ,Zhang L,Adler MW,Eisenstein TK

更新日期：2004-02-01 00:00:00

abstract：:The skin response to myelin basic protein (MBP) was studied in chronic relapsing experimental allergic encephalomyelitis (EAE) using strain 13 guinea pigs. The delayed type skin response showed a monophasic curve; it gradually increased after immunization, reached maximum levels around 80 days post-immunization, and d...

journal_title：Journal of neuroimmunology

authors： Tabira T,Itoyama Y,Kuroiwa Y,Kubo C,Nagai Y

更新日期：1983-12-01 00:00:00

abstract：:Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very...

journal_title：Journal of neuroimmunology

authors： Kakoulidou M,Ahlberg R,Yi Q,Giscombe R,Pirskanen R,Lefvert AK

更新日期：2004-03-01 00:00:00

abstract：:Stress, either psychological or physical, can have a dramatic impact on the immune system. Toll-like receptors (TLRs) play a pivotal role in the induction of innate and adaptive immune response. We have reported that stress modulates the immune response in a TLR4-dependent manner. However, the mechanisms underlying TL...

journal_title：Journal of neuroimmunology

authors： Zhang Y,Zhang Y,Miao J,Hanley G,Stuart C,Sun X,Chen T,Yin D

更新日期：2008-11-15 00:00:00

abstract：:This report is to alert other investigators that Lewis rats, which are widely employed in studies of autoimmune diseases, vary considerably with respect to susceptibility to experimental autoimmune encephalomyelitis (EAE), depending upon commercial source. ...

journal_title：Journal of neuroimmunology

authors： Gould KE,Stepaniak JA,Swanborg RH

更新日期：1994-10-01 00:00:00

abstract：:In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched h...

journal_title：Journal of neuroimmunology

authors： Plantone D,Marti A,Frisullo G,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Mirabella M,Batocchi AP

更新日期：2013-12-15 00:00:00

abstract：:Reactive oxygen intermediates (ROIs) are important mediators of a variety of pathological processes, including inflammation and ischemia/reperfusion injury. Cytokines and chemokines are detected at mRNA level in human and animal ischemic brains. This suggests that hypoxia/reoxygenation may induce cytokine production t...

journal_title：Journal of neuroimmunology

authors： Wang MJ,Huang HM,Hsieh SJ,Jeng KC,Kuo JS

更新日期：2001-01-01 00:00:00

abstract：:The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. Howe...

journal_title：Journal of neuroimmunology

authors： Jilek S,Kuhle J,Meylan P,Reichhart MD,Pantaleo G,Du Pasquier RA

更新日期：2007-12-01 00:00:00

abstract：:B cells are of increasing importance as a target for multiple sclerosis treatment. Here we show that GA treatment of mice with experimental autoimmune encephalomyelitis (EAE) biases cytokine production by B cells towards cytokines associated with regulation in MS including interleukin (IL)-4, -10 and -13 and reduces p...

journal_title：Journal of neuroimmunology

authors： Begum-Haque S,Sharma A,Christy M,Lentini T,Ochoa-Reparaz J,Fayed IF,Mielcarz D,Haque A,Kasper LH

更新日期：2010-02-26 00:00:00

abstract：:Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR, which inhibits kinase activity by binding to the activation loop of ...

journal_title：Journal of neuroimmunology

authors： Jager LD,Dabelic R,Waiboci LW,Lau K,Haider MS,Ahmed CM,Larkin J 3rd,David S,Johnson HM

更新日期：2011-03-01 00:00:00

abstract：:Emergent or elective surgical procedures may be complicated by sepsis, resulting in critical illness that can lead to organ failure and death. The opioid drug, morphine is widely used to alleviate pain in post-surgical patients; however, it is well documented that chronic treatment of mice with morphine affects the pr...

journal_title：Journal of neuroimmunology

authors： Roy S,Charboneau RG,Barke RA

更新日期：1999-03-01 00:00:00

abstract：:The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterize...

journal_title：Journal of neuroimmunology

authors： Gallo P,Piccinno MG,De Rossi A,Pagni S,Amadori A,Chieco-Bianchi L,Tavolato B

更新日期：1990-03-01 00:00:00

abstract：:We investigated the role of intracerebroventricular (ICV) injection of rimonabant (500ng), a CB1 antagonist, on lipopolysaccharide ((LPS) 5mg/kg)-induced pulmonary inflammation in rats in an isolated perfused lung model. There were decreases in pulmonary capillary pressure (Ppc) and increases in the ((Wet-Dry)/Dry lun...

journal_title：Journal of neuroimmunology

authors： Johnson A,Neumann PH,Peng J,James J,Russo V,MacDonald H,Gertzberg N,Feleder C

更新日期：2015-09-15 00:00:00

abstract：:Thirty patients with clinically isolated syndromes (CIS) were evaluated at the onset of neurological symptoms and when they developed clinically definite MS (CDMS). Surface expression of LFA-1alpha, VLA-4 and intercellular adhesion molecule-1 (ICAM-1) on PBMC and CSF cells was evaluated using flow cytometry. Serum and...

journal_title：Journal of neuroimmunology

authors： Correale J,Bassani Molinas Mde L

更新日期：2003-07-01 00:00:00

abstract：:We have analyzed a CA repeat polymorphism localized 46-kb upstream of the Fas ligand gene in Spanish and American populations that include 139 healthy controls and a cohort of 177 unrelated relapsing and remitting multiple sclerosis (MS) patients. The MS patients consisted of two groups, one with a family history of M...

journal_title：Journal of neuroimmunology

authors： Zayas MD,Lucas M,Solano F,Fernández-Pérez MJ,Izquierdo G

更新日期：2001-06-01 00:00:00

abstract：:H-2 class I antigens, but not class II antigens, were detected on the surface of glial cells persistently infected with mouse hepatitis virus strain A59 (MHV-A59) as late as 90 days post-infection. Uninfected glial cells remained negative for H-2 class I and class II surface antigens. We have previously shown that con...

journal_title：Journal of neuroimmunology

authors： Lavi E,Suzumura A,Murray EM,Silberberg DH,Weiss SR

更新日期：1989-04-01 00:00:00

abstract：:The chemokine interleukin 8/CXCL8 induces the phosphorylation of the GluR1 subunit of the AMPA-type glutamate receptor in neurons and transfected HEK cells, on both serine 845 (S845) and 831 (S831) residues. We previously described that CXCL8 receptor CXCR2 and GluR1 co-precipitate and that GluR1/CXCR2 co-expression b...

journal_title：Journal of neuroimmunology

authors： Catalano M,Trettel F,Cipriani R,Lauro C,Sobrero F,Eusebi F,Limatola C

更新日期：2008-07-31 00:00:00

abstract：:To determine clinical features of neurologic disorders associated with anti-glutamic acid decarboxylase antibodies (anti-GAD-Ab), we examined titers and time-dependent changes of anti-GAD-Ab. Six patients, stiff person syndrome (2), cerebellar ataxia (1), limbic encephalitis (1), epilepsy (1), brainstem encephalitis (...

journal_title：Journal of neuroimmunology

authors： Nakajima H,Nakamura Y,Inaba Y,Tsutsumi C,Unoda K,Hosokawa T,Kimura F,Hanafusa T,Date M,Kitaoka H

更新日期：2018-04-15 00:00:00