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Norepinephrine inhibits gamma-interferon-induced MHC class II (Ia) antigen expression on cultured brain astrocytes.

Abstract：

:Recent evidence that astrocytes can be induced to express the class II major histocompatability (MHC) antigens suggests that these cells may be involved in the development of intracerebral immune responses. The principal inducer of MHC class II antigen (Ia) expression is a soluble lymphokine, gamma-interferon (gamma-IFN). Normally astrocytes do not express significant levels of Ia antigens despite the fact that agents such as gamma-IFN may be present in the central nervous system (CNS). Here we report that a major neurotransmitter, norepinephrine (NE), inhibits, in a dose-response fashion, the ability of gamma-IFN to induce Ia antigen expression on cultured astrocytes derived from newborn BALB/c mice. This finding may indicate that the brain contains inhibitory modulators that serve to prevent the up-regulation of intracerebral immune responsiveness.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Frohman EM,Vayuvegula B,van den Noort S,Gupta S

doi

10.1016/0165-5728(88)90017-3

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

89-101

issue

2

eissn

0165-5728

issn

1872-8421

pii

0165-5728(88)90017-3

journal_volume

17

pub_type

杂志文章

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