Epstein-Barr virus and multiple sclerosis: cellular immune response and cross-reactivity.


:We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-γ secreting cells following stimulation with autologous EBV-infected lymphoblastoid cell lines (LCL) in MS patients and matched controls. There were no statistically significant differences for any of the measured responses, but there was a trend towards decreased proliferative responses in MS patients. There was no measured cross-reactivity between LCL and brain antigens. We conclude that the cellular immune response against EBV-infected cells is neither increased nor decreased in MS.


J Neuroimmunol


Lindsey JW,Hatfield LM




Has Abstract


2010-12-15 00:00:00














  • Human myelin basic protein specific T cell lines display differential cytotoxicity against astrocytes, but are consistently cytotoxic against monocytes.

    abstract::In experimental allergic encephalomyelitis (EAE) myelin basic protein (MBP) specific T cells differ in their encephalitogenic potential. To investigate the functional diversity of human MBP specific T cell lines, we analysed their cytotoxic activity against human astrocytes and monocytes. Five out of 14 MBP specific T...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Weber F,Huber S,Aloisi F,Meinl E

    更新日期:1998-08-01 00:00:00

  • Regional suppression, therapy after onset and prevention of relapses in experimental allergic encephalomyelitis by mitoxantrone.

    abstract::Mitoxantrone, a new antineoplastic anthracenedione drug, suppressed the development of experimental allergic encephalomyelitis (EAE) in rats when administered during the incubation period. One dose of mitoxantrone had a favorable effect on EAE even when withheld until after the onset of clinical signs. In a model of r...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Levine S,Saltzman A

    更新日期:1986-12-01 00:00:00

  • MP4- and MOG:35-55-induced EAE in C57BL/6 mice differentially targets brain, spinal cord and cerebellum.

    abstract::Mechanism-oriented studies of EAE rely mostly on gene-modified mice on the C57BL/6 background. Here we report that MP4-induced EAE displays characteristic differences in CNS pathology as compared to MOG peptide 35-55-elicited disease. While in the latter, the topology of CNS infiltration remained unchanged throughout ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kuerten S,Kostova-Bales DA,Frenzel LP,Tigno JT,Tary-Lehmann M,Angelov DN,Lehmann PV

    更新日期:2007-09-01 00:00:00

  • Peripheral challenge with a viral mimic upregulates expression of the complement genes in the hippocampus.

    abstract::Peripheral challenge with a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces hippocampal hyperexcitability in mice. Here, we characterized this hippocampal response through a whole genome transcriptome analysis. Intraperitoneal injection of PIC resulted in temporal dysregulation of 625 genes in the hippoca...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Michalovicz LT,Lally B,Konat GW

    更新日期:2015-08-15 00:00:00

  • Role of the innate immune system in the pathogenesis of multiple sclerosis.

    abstract::Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous clinical presentations and course. MS is considered to be a T cell mediated disease but in recent years contribution of innate immune cells in mediating MS pathogenesis is being appreciated. In this review, we have discussed the ro...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Gandhi R,Laroni A,Weiner HL

    更新日期:2010-04-15 00:00:00

  • The neuropeptides α-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells.

    abstract::Within the immunosuppressive ocular microenvironment, there are constitutively present the immunomodulating neuropeptides alpha-melanocyte stimulating hormone (α-MSH) and neuropeptide Y (NPY) that promote suppressor functionality in macrophages. In this study, we examined the possibility that α-MSH and NPY modulate ph...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Phan TA,Taylor AW

    更新日期:2013-07-15 00:00:00

  • Monoclonal antibodies against the main immunogenic region of the acetylcholine receptor. Mapping on the intact molecule.

    abstract::About two-thirds of the antibodies to the nicotinic acetylcholine receptor (AChR) in myasthenic patients, and in rats immunized with intact AChR, bind to the main immunogenic region (MIR) on the alpha-subunit. We tested all available anti-MIR monoclonal antibodies (mAbs) by competition experiments for binding on the i...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kordossi AA,Tzartos SJ

    更新日期:1989-06-01 00:00:00

  • Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia.

    abstract::Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein. In a previous study, we showed that neurotoxic prion peptide (PrP106-126) induced NALP3 inflammasome activation in mouse primary and immortalized microglia. In the present work, we examined the relevance of pha...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Shi F,Yang Y,Kouadir M,Fu Y,Yang L,Zhou X,Yin X,Zhao D

    更新日期:2013-07-15 00:00:00

  • T-cell-mediated epineurial vasculitis and humoral-mediated microangiopathy in cryoglobulinemic neuropathy.

    abstract::We used immunohistochemistry to assess the role of humoral and cellular factors in endoneurial microangiopathy and epineurial vasculitis in 15 nerve biopsies of patients with axonal neuropathy and monoclonal or mixed cryoglobulinemia (CG). Deposition of immunoglobulins and cytolytic complement was detected in endoneur...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Bonetti B,Invernizzi F,Rizzuto N,Bonazzi ML,Zanusso GL,Chinaglia G,Monaco S

    更新日期:1997-03-01 00:00:00

  • Circulating T-cell subsets in Guillain-Barré syndrome.

    abstract::We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8+ (putative suppressor...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lisak RP,Zweiman B,Guerrero F,Moskovitz AR

    更新日期:1985-05-01 00:00:00

  • Dopamine, vesicular transporters and dopamine receptor expression and localization in rat thymus and spleen.

    abstract::The localization of dopamine stores and the expression and localization of vesicular monoamine transporter (VMAT) type-1 and 2 and of dopamine D1-like and D2-like receptor subtypes were investigated in rat thymus and spleen by immunohistochemical, immunochemical techniques and by RT-PCR. In the thymus dopamine immunor...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Mignini F,Tomassoni D,Traini E,Amenta F

    更新日期:2009-01-03 00:00:00

  • Tumor necrosis factor-alpha impairs the recovery of synaptic transmission from hypoxia in rat hippocampal slices.

    abstract::Cerebral ischaemia is a common occurrence in a range of pathological conditions, including stroke and traumatic brain injury. Two of the components in ischaemia are tissue hypoxia and the release of pro-inflammatory agents such as TNF-alpha. The role of TNF-alpha in an ischaemic/hypoxic episode is still controversial,...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Batti L,O'Connor JJ

    更新日期:2010-01-25 00:00:00

  • Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1 beta and TNF alpha.

    abstract::Resident glial cells and invading inflammatory cells are responsible for cytokine production within the brain. Astrocytes are known to secrete a variety of cytokines upon stimulation with cytokines themselves, protein kinase C activators, bacterial or viral constituents. Astrocytes also have surface receptors for a wi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Maimone D,Cioni C,Rosa S,Macchia G,Aloisi F,Annunziata P

    更新日期:1993-08-01 00:00:00

  • Interferon-beta specifically inhibits interferon-gamma-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line.

    abstract::We established cultures of human astrocytes and astrocytoma cells from surgical specimens, to study regulation of class II major histocompatibility (MHC) complex antigen expression by interferons. Using these cultures we previously showed that expression of the class II MHC determinant HLA-DR could be induced by inter...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Ransohoff RM,Devajyothi C,Estes ML,Babcock G,Rudick RA,Frohman EM,Barna BP

    更新日期:1991-08-01 00:00:00

  • Immunocytochemical characterisation of cell cultures grown from dissociated 1-2-day post-natal rat cerebral tissue. A developmental study.

    abstract::A range of cell-specific markers have been employed with immunocytochemical methods to characterise and quantitate the cell types present in mixed brain cell cultures derived from dissociated 1-2-day post-natal rat cerebral hemispheres and grown in the presence of FCS. Protoplasmic astrocytes (GFAP+, A2B5-) were the m...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Walker AG,Chapman J,Bruce CB,Rumsby MG

    更新日期:1984-11-01 00:00:00

  • Exacerbation of lymphocytic choriomeningitis in mice treated with the inducible nitric oxide synthase inhibitor aminoguanidine.

    abstract::To elucidate the possible involvement of the inducible nitric oxide synthase (iNOS) and NO in the development of lymphocytic choriomeningitis (LCM), the consequences of inhibition of iNOS by the inhibitor aminoguanidine was examined in mice following intracerebral infection with LCM virus (LCMV). Aminoguanidine admini...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Campbell IL

    更新日期:1996-12-01 00:00:00

  • A novel soluble brain-specific protein (Sy-1). Identification and partial characterization.

    abstract::A novel brain-specific antigen, called Sy-1, has been identified in whole rat brain hypotonic extracts by means of an antiserum produced in rabbits against the synaptosomal cytosol. Sy-1 is an acidic protein (pI 4.7) present exclusively in a soluble form and it does not carry any sugar moiety. Sy-1 is found only in ra...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Gennarini G,Corsi P,Pavia R,Vitiello F,Di Benedetta C

    更新日期:1983-04-01 00:00:00

  • The immunopathogenesis of Miller Fisher syndrome.

    abstract::Over the past decade, remarkable progress has been made in our understanding of the pathogenesis of Miller Fisher syndrome (MFS), a clinical variant of Guillain Barré syndrome (GBS). MFS comprises the clinical triad of ataxia, areflexia and ophthalmoplegia. It is associated with acute-phase IgG antibodies to GQ1b and ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Willison HJ,O'Hanlon GM

    更新日期:1999-12-01 00:00:00

  • Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses.

    abstract::Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects. Here, we examined the effects of berberine on dopamine receptors and the ensuing anti-inflammatory responses. Berberine was found to be an antagonist at both dopamine D1- and D2-like receptors an...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kawano M,Takagi R,Kaneko A,Matsushita S

    更新日期:2015-12-15 00:00:00

  • The localisation of fibrin, fibronectin and class II major histocompatibility complex antigen in the spinal cord in chronic relapsing experimental allergic encephalomyelitis.

    abstract::Light and electron immunocytochemistry using antibodies recognising a class II major histocompatibility complex antigen, fibrin, fibronectin, albumin and factor VIII related antigen has been used to stain sections of spinal cord from normal guinea pigs and those with chronic relapsing experimental allergic encephalomy...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Butter C,Healey DG,Agha N,Wilcox CE,Antoniou AV,Turk JL

    更新日期:1989-03-01 00:00:00

  • Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay.

    abstract::NMO-IgG, a disease-specific autoantibody for neuromyelitis optica, recognizes aquaporin-4 (AQP4) and has been examined by indirect immunofluorescence assay. We developed an enzyme-linked immunosorbent assay (ELISA) to detect anti-AQP4 antibodies by establishing methods for expression in a baculovirus system and purifi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Hayakawa S,Mori M,Okuta A,Kamegawa A,Fujiyoshi Y,Yoshiyama Y,Mitsuoka K,Ishibashi K,Sasaki S,Hattori T,Kuwabara S

    更新日期:2008-05-30 00:00:00

  • Wallerian degeneration induces Ia-antigen expression in the rat brain.

    abstract::Strong expression of class II major histocompatibility (MHC II, Ia) antigens was observed in areas of Wallerian degeneration following either a cryoinjury to the cerebral and cerebellar cortex or unilateral eye enucleation in adult Wistar and Lewis rats. The Wallerian degeneration was disclosed by the Fink-Heimer meth...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Konno H,Yamamoto T,Iwasaki Y,Suzuki H,Saito T,Terunuma H

    更新日期:1989-12-01 00:00:00

  • Comparison of ventricular and lumbar cerebrospinal fluid T cells in non-inflammatory neurological disorder (NIND) patients.

    abstract::The aim of the present study was to define the cellular composition of ventricular, as compared with lumbar, cerebrospinal fluid (CSF) in patients with non-inflammatory neurological disorders (NIND). We addressed this issue by determining the cellular composition of lumbar CSF from patients with normal pressure hydroc...

    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章


    authors: Provencio JJ,Kivisäkk P,Tucky BH,Luciano MG,Ransohoff RM

    更新日期:2005-06-01 00:00:00

  • Temporal variations of adhesion molecules and matrix metalloproteinases in the course of MS.

    abstract::Thirty patients with clinically isolated syndromes (CIS) were evaluated at the onset of neurological symptoms and when they developed clinically definite MS (CDMS). Surface expression of LFA-1alpha, VLA-4 and intercellular adhesion molecule-1 (ICAM-1) on PBMC and CSF cells was evaluated using flow cytometry. Serum and...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Correale J,Bassani Molinas Mde L

    更新日期:2003-07-01 00:00:00

  • Soluble CD4 and CD8 in the peripheral blood of patients with multiple sclerosis and HTLV-1-associated myelopathy.

    abstract::We evaluated the presence of soluble (s) CD4 and sCD8, released from activated T cells, in the sera of patients with multiple sclerosis (MS) and human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA). In addition, peripheral blood T cell subsets in pat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Tsukada N,Matsuda M,Miyagi K,Yanagisawa N

    更新日期:1991-12-01 00:00:00

  • Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients.

    abstract::Interferon-beta (IFN-beta) achieves its beneficial effect on multiple sclerosis (MS) via anti-inflammatory properties. In this study, we assessed the expression of the brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear cells (PBMC) from relapsing-remitting multiple sclerosis (RRMS) patients treat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lalive PH,Kantengwa S,Benkhoucha M,Juillard C,Chofflon M

    更新日期:2008-07-15 00:00:00

  • Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy.

    abstract::The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-alpha:TNF-alpha-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (Cbl)-deficient (Cbl-D) rats. They were normalized or significantly reduced after...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Veber D,Mutti E,Galmozzi E,Cedrola S,Galbiati S,Morabito A,Tredici G,La Porta CA,Scalabrino G

    更新日期:2006-07-01 00:00:00

  • Phenotypes and alloantigen-presenting activity of individual clones of microglia derived from the mouse brain.

    abstract::To clarify the origin and function of the microglia residing in the central nervous system, we cloned brain cells from newborn and adult mice in soft agar containing the macrophage-specific growth factor, colony-stimulating factor-1 and expanded the cells from individual colonies in liquid culture medium. The results ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Moore SC,McCormack JM,Armendariz E,Gatewood J,Walker WS

    更新日期:1992-12-01 00:00:00

  • Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity.

    abstract::Muscle weakness in MuSK myasthenia gravis (MG) is caused predominantly by IgG4 antibodies which block MuSK signalling and destabilize neuromuscular junctions. We determined whether the binding pattern of MuSK IgG4 antibodies change throughout the disease course ("epitope spreading"), and affect disease severity or tre...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Huijbers MG,Vink AF,Niks EH,Westhuis RH,van Zwet EW,de Meel RH,Rojas-García R,Díaz-Manera J,Kuks JB,Klooster R,Straasheijm K,Evoli A,Illa I,van der Maarel SM,Verschuuren JJ

    更新日期:2016-02-15 00:00:00

  • Neuroprotection and enhanced neurogenesis by extract from the tropical plant Knema laurina after inflammatory damage in living brain tissue.

    abstract::Inflammatory reactions in the CNS, resulting from a loss of control and involving a network of non-neuronal and neuronal cells, are major contributors to the onset and progress of several major neurodegenerative diseases. Therapeutic strategies should therefore keep or restore the well-controlled and finely-tuned bala...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Häke I,Schönenberger S,Neumann J,Franke K,Paulsen-Merker K,Reymann K,Ismail G,Bin Din L,Said IM,Latiff A,Wessjohann L,Zipp F,Ullrich O

    更新日期:2009-01-03 00:00:00