Epstein-Barr virus and multiple sclerosis: cellular immune response and cross-reactivity.

Abstract:

:We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-γ secreting cells following stimulation with autologous EBV-infected lymphoblastoid cell lines (LCL) in MS patients and matched controls. There were no statistically significant differences for any of the measured responses, but there was a trend towards decreased proliferative responses in MS patients. There was no measured cross-reactivity between LCL and brain antigens. We conclude that the cellular immune response against EBV-infected cells is neither increased nor decreased in MS.

journal_name

J Neuroimmunol

authors

Lindsey JW,Hatfield LM

doi

10.1016/j.jneuroim.2010.08.009

subject

Has Abstract

pub_date

2010-12-15 00:00:00

pages

238-42

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(10)00373-5

journal_volume

229

pub_type

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