当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells.

Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells.

Abstract：

:Human G-protein-coupled formyl peptide receptor-like 1 and its mouse homologue formyl peptide receptor 2 mediate the chemotactic activity of a variety of pathogen and host-derived peptides, including amyloid beta(42), a key causative factor in Alzheimer's disease (AD).Here, we found that polyinosine-polycytidylic acid (Poly(I:C)), which is a specific TLR3 ligand, and Imiquimod (R837), which is a specific TLR7 ligand, when used alone, each increased MAPK-dependent functional mFPR2 expression in microglial cells, and the combination of Poly(I:C) and R837 exhibited additive effect by enhancing the level of IkappaB-alpha phosphorylation. Our results indicated that RNA virus infection may actively participate in the pathogenic processes of brain inflammation and neurodegenerative diseases by TLR3- and TLR7-mediated TRIF-dependent and MyD88-dependent signaling pathways.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Chen K,Huang J,Liu Y,Gong W,Cui Y,Wang JM

doi

10.1016/j.jneuroim.2009.05.018

subject

Has Abstract

pub_date

2009-08-18 00:00:00

pages

69-77

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(09)00213-6

journal_volume

213

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • How cytokines can influence the brain: a role for chemokines?

    abstract：:Following inflammation or infection, cytokines are released in the blood. Besides their effect on the immune system, cytokines can also act in the brain to modulate our behaviors, inducing for example anorexia when produced in large amount. This review focuses on our current knowledge on how cytokines can influence th...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2008.04.009

    authors： Guyon A,Massa F,Rovère C,Nahon JL

    更新日期：2008-07-31 00:00:00

  • Body mass index influence interferon-beta treatment response in multiple sclerosis.

    abstract：:Obesity is a possible risk factor of multiple sclerosis (MS), but the association between obesity and MS disease activity has not been explored. In a cohort of 86 MS patients, 80% of overweight or obese patients (BMI≥25kg/m(2)) had MRI activity compared to 48% of the normal-weight patients (BMI<25kg/m(2)) (p=0.001) du...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jneuroim.2015.09.008

    authors： Kvistad SS,Myhr KM,Holmøy T,Šaltytė Benth J,Wergeland S,Beiske AG,Bjerve KS,Hovdal H,Lilleås F,Midgard R,Pedersen T,Bakke SJ,Michelsen AE,Aukrust P,Ueland T,Sagen JV,Torkildsen Ø

    更新日期：2015-11-15 00:00:00

  • Peripheral challenge with a viral mimic upregulates expression of the complement genes in the hippocampus.

    abstract：:Peripheral challenge with a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces hippocampal hyperexcitability in mice. Here, we characterized this hippocampal response through a whole genome transcriptome analysis. Intraperitoneal injection of PIC resulted in temporal dysregulation of 625 genes in the hippoca...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.06.003

    authors： Michalovicz LT,Lally B,Konat GW

    更新日期：2015-08-15 00:00:00

  • Guillain-Barré syndrome with IgM antibody to the ganglioside GalNAc-GD1a.

    abstract：:We analyzed the characteristics of 29 Guillain-Barré syndrome (GBS) patients with IgM anti-GalNAc-GD1a antibodies. Fourteen of them had had an antecedent cytomegalovirus infection (CMV group) and 12 gastrointestinal infection (G-I group). Most of the G-I group patients (nine of 12) were subsequent to Campylobacter jej...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00451-3

    authors： Kaida K,Kusunoki S,Kamakura K,Motoyoshi K,Kanazawa I

    更新日期：2001-02-15 00:00:00

  • Evidence for genetic contamination of inbred buffalo rats (RT-1b) obtained from a commercial vendor.

    abstract：:Inbred Buffalo rats (RT-1b) have been used in studies of experimental autoimmune encephalomyelitis and autoimmune thyroiditis. Since our studies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain-dependent, allotype-specific variants ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90115-5

    authors： Jones RE,Weinberg A,Bourdette D

    更新日期：1994-07-01 00:00:00

  • Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing?

    abstract：:Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jneuroim.2009.09.013

    authors： Conrady CD,Drevets DA,Carr DJ

    更新日期：2010-03-30 00:00:00

  • Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE.

    abstract：:Multiple sclerosis (MS) is a demyelinating disease characterized by the breakdown of the blood-brain barrier (BBB), and accumulation of inflammatory infiltrates in the central nervous system. Tight junctions are specialized cell-cell adhesion structures and critical components of the BBB that have previously been show...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2010.08.011

    authors： Bennett J,Basivireddy J,Kollar A,Biron KE,Reickmann P,Jefferies WA,McQuaid S

    更新日期：2010-12-15 00:00:00

  • Primary and secondary involvement of the CNS in HIV infection.

    abstract：:The neurologic sequelae of human immunodeficiency virus (HIV) infection may be divided into primary (= HIV-induced) and secondary (= opportunistic infections and malignancies) manifestations. Our experience with 215 HIV-infected patients indicates that major clinical symptoms are due to a few, albeit important, neurol...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章,评审

    doi：10.1016/0165-5728(88)90143-9

    authors： Fischer PA,Enzensberger W

    更新日期：1988-12-01 00:00:00

  • Virus-activated T cells regulate expression of adhesion molecules on endothelial cells in sites of infection.

    abstract：:To study the role of cell adhesion molecules in the fatal CD8+ T-cell mediated meningitis which is induced by intracerebral infection with lymphocytic choriomeningitis virus, the expression of relevant molecules on inflammatory cells and local endothelium was analyzed immunohistochemically. Most inflammatory cells wer...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(95)00099-n

    authors： Marker O,Scheynius A,Christensen JP,Thomsen AR

    更新日期：1995-10-01 00:00:00

  • Increase of Ki-67+ natural killer cells in multiple sclerosis patients treated with interferon-β and interferon-β combined with low-dose oral steroids.

    abstract：:Interferon-β (IFN-β) is known to expand regulatory CD56(bright) natural killer (NK) cells in multiple sclerosis (MS). In this cross-sectional study we show that MS patients treated with IFN-β alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2011.05.005

    authors： Sanvito L,Tomita A,Chihara N,Okamoto T,Lin Y,Ogawa M,Gran B,Aranami T,Yamamura T

    更新日期：2011-07-01 00:00:00

  • The significance of oligoclonal bands in multiple sclerosis: relevance of demographic and clinical features, and immunogenetic backgrounds.

    abstract：:There has been no data on oligoclonal IgG bands (OCBs) for Turkish MS population, who is believed to be placed between Western and Eastern world regarding the clinical and immunological features. In the present study, we examined the correlation between the frequency of OCB and clinical and demographical features of M...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2009.04.014

    authors： Idiman E,Ozakbas S,Dogan Y,Kosehasanogullari G

    更新日期：2009-07-25 00:00:00

  • Interleukin 1-beta modulates the effects of hypoxia in neuronal culture.

    abstract：:In order to study the role of interleukin-1beta (IL-1beta) in homeostasis, hypoxia and recovery of neuronal cells, we studied the expression and release of tumor necrosis factor-alpha (TNF-alpha) and nerve growth factor (NGF), in relation to the presence or absence of this cytokine in culture medium. Moreover, we eval...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00209-5

    authors： Di Loreto S,Corvetti L,Maccarone R,Piancatelli D,Adorno D

    更新日期：2000-07-01 00:00:00

  • PD-1 immune checkpoint blockade promotes brain leukocyte infiltration and diminishes cyst burden in a mouse model of Toxoplasma infection.

    abstract：:Tissue cysts, the hallmark of chronic Toxoplasma gondii infection, are predominantly located in the brain making clearance of the parasite difficult. Currently available anti-T. gondii drugs are ineffective on cysts and fail to prevent reactivation of latent toxoplasmosis. We examined whether abrogation of inhibitory ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.03.013

    authors： Xiao J,Li Y,Yolken RH,Viscidi RP

    更新日期：2018-06-15 00:00:00

  • The role of regulatory T cells in Lewis rats resistant to EAE.

    abstract：:Adult Lewis (LEW) rats are highly susceptible to experimental autoimmune encephalomyelitis (EAE), induced actively by immunization with guinea pig (GP) myelin basic protein (MBP) in complete Freund's adjuvant or adoptively transferred with activated T lymphocytes reactive to GP MBP peptide 68-88. Once LEW rats recover...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00176-8

    authors： Sun D,Wilson DB,Cao L,Whitaker JN

    更新日期：1998-01-01 00:00:00

  • Lymphocyte responsiveness to lectin and myelin antigens in canine distemper infection in relation to the development of demyelinating lesions.

    abstract：:Eleven dogs were experimentally infected with canine distemper virus and studied for periods of up to 63 days post-inoculation. The responsiveness of lymphocytes in vitro toward phytohemagglutinin, myelin basic protein and galactocerebroside was tested at regular intervals during the course of infection by means of [3...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(83)90013-9

    authors： Cerruti-Sola S,Kristensen F,Vandevelde M,Bichsel P,Kihm U

    更新日期：1983-04-01 00:00:00

  • Time course of penetration of xenogeneic IgG into the central nervous system of the neonatal rat: an immunohistochemical and radionuclide tracer study.

    abstract：:We investigated the penetration of rabbit IgG into the brain and spinal cord of newborn rat pups and compared them to mature rats using immunohistochemical and radionuclide techniques. Following intraperitoneal injection with rabbit IgG and perfusion fixation at various intervals, rabbit IgG was found to penetrate int...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90116-1

    authors： Fabian RH,Hulsebosch CE

    更新日期：1989-10-01 00:00:00

  • Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice.

    abstract：:Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronc...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2020.577450

    authors： Caulfield JI,Schopf KJ,Cavigelli SA

    更新日期：2020-11-25 00:00:00

  • Variable patterns of anti-GM(1) IgM-antibody populations defined by affinity and fine specificity in patients with motor syndromes: evidence for their random origin.

    abstract：:Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(01)00355-1

    authors： Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

    更新日期：2001-09-03 00:00:00

  • Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP- and MOG-specific lymphocyte activation and chemotactic migration in multiple sclerosis patients.

    abstract：:The present study was aimed at confirming the presence of GluR3 on T lymphocytes and to assess the effect of glutamate on proliferative responses to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) and chemotactic migration to CXCL12/stromal cell-derived factor-1, RANTES, and MIP-1alpha in 15 c...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.05.021

    authors： Sarchielli P,Di Filippo M,Candeliere A,Chiasserini D,Mattioni A,Tenaglia S,Bonucci M,Calabresi P

    更新日期：2007-08-01 00:00:00

  • Human glioblastoma cell line 86HG39 activates T cells in an antigen specific major histocompatibility complex class II-dependent manner.

    abstract：:The capacity of three different human glioblastoma cell lines to activate human T cells was analysed by measuring major histocompatibility complex (MHC) antigen expression, monokine secretion and lectin, mAb OKT3 and antigen-driven T cell proliferation. All glioblastoma cells tested were able to induce PHA and concana...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90191-m

    authors： Däubener W,Zennati SS,Wernet P,Bilzer T,Fischer HG,Hadding U

    更新日期：1992-11-01 00:00:00

  • Epitope specificity and V gene expression of cerebrospinal fluid T cells specific for intact versus cryptic epitopes of myelin basic protein.

    abstract：:Recent evidence supports the possible involvement of myelin basic protein (BP) as one of the target autoantigens in multiple sclerosis (MS), including elevated frequencies of MS blood and cerebrospinal fluid (CSF) T cells, and the presence in MS plaque tissue of V beta gene sequences and CDR3 motifs characteristic of ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90268-4

    authors： Satyanarayana K,Chou YK,Bourdette D,Whitham R,Hashim GA,Offner H,Vandenbark AA

    更新日期：1993-04-01 00:00:00

  • T cell cytokine signatures: Biomarkers in pediatric multiple sclerosis.

    abstract：:Although multiple sclerosis is predominantly regarded as a disease of young adulthood, up to 5% of MS patients are diagnosed prior to age eighteen. The predominant form of MS is relapsing-remitting characterized by exacerbations of symptoms followed by periods of remission. The majority of disease modifying drugs targ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2016.04.015

    authors： Cala CM,Moseley CE,Steele C,Dowdy SM,Cutter GR,Ness JM,DeSilva TM

    更新日期：2016-08-15 00:00:00

  • Induction of antibodies against murine full-length prion protein in wild-type mice.

    abstract：:The causative and infectious agent of the transmissible spongiform encephalopathies, e.g. bovine spongiform encephalopathy in cattle or variant Creutzfeldt-Jakob disease in humans, is a pathogenic form of the scrapie prion protein (PrP(Sc)) generated by a conformational rearrangement in the normal cellular prion prote...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00316-8

    authors： Koller MF,Grau T,Christen P

    更新日期：2002-11-01 00:00:00

  • Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions.

    abstract：:Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions a...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(03)00036-5

    authors： Vos CM,van Haastert ES,de Groot CJ,van der Valk P,de Vries HE

    更新日期：2003-05-01 00:00:00

  • Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis.

    abstract：:Since multiple sclerosis (MS) is believed to be an immune-mediated disease, it follows that its therapies should be directed towards modulating the immune system. Current MS treatments, which include the use of exogenous steroids that are immunosuppressive, do not meet therapeutic objectives. delta 9-Tetrahydrocannabi...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(89)90075-1

    authors： Lyman WD,Sonett JR,Brosnan CF,Elkin R,Bornstein MB

    更新日期：1989-06-01 00:00:00

  • alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain.

    abstract：:The purpose of this study was to determine if alpha-tocopherol-a reactive oxygen species (ROS) scavenging agent-inhibits LPS-induced oxidative stress and interleukin-6 (IL-6) production in murine microglia and brain. LPS increased intracellular peroxides and IL-6 in a dose-dependent fashion in primary microglia. The L...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2003.12.017

    authors： Godbout JP,Berg BM,Kelley KW,Johnson RW

    更新日期：2004-04-01 00:00:00

  • Elevated B-cell activating factor BAFF, but not APRIL, correlates with CSF cerebellar autoantibodies in pediatric opsoclonus-myoclonus syndrome.

    abstract：:Childhood opsoclonus-myoclonus syndrome (OMS) occurs idiopathic or, in association with a neuroblastoma, as a paraneoplastic syndrome. Since autoantibodies were identified in some patients, an autoimmune pathogenesis has been suspected. While the newly discovered B-cell activating factors BAFF and APRIL are involved i...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2009.03.006

    authors： Fühlhuber V,Bick S,Kirsten A,Hahn A,Gerriets T,Tschernatsch M,Kaps M,Preissner KT,Blaes F,Altenkämper S

    更新日期：2009-05-29 00:00:00

  • Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity.

    abstract：:IgG fractions of sera containing anti-Hu antibodies or control sera were incubated with Hu-positive and Hu-negative cell lines. Anti-Hu IgG specifically localized in the nucleus of Hu-positive cells. Anti-Hu-positive and control sera were incubated with Hu-positive cells and human complement or peripheral blood mononu...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90011-6

    authors： Hormigo A,Lieberman F

    更新日期：1994-12-01 00:00:00

  • Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model.

    abstract：:Emergent or elective surgical procedures may be complicated by sepsis, resulting in critical illness that can lead to organ failure and death. The opioid drug, morphine is widely used to alleviate pain in post-surgical patients; however, it is well documented that chronic treatment of mice with morphine affects the pr...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00265-3

    authors： Roy S,Charboneau RG,Barke RA

    更新日期：1999-03-01 00:00:00

  • IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity.

    abstract：:Immunization with the whole cell pertussis vaccine (Pw), but not the acellular pertussis vaccine (Pa), is associated with a number of neurological side effects. Previously, we have demonstrated a role for interleukin-1beta (IL-1beta) in Pw reactogenicity. Here we report that parenteral Pw administration resulted in a ...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00468-x

    authors： Armstrong ME,Loscher CE,Lynch MA,Mills KH

    更新日期：2003-03-01 00:00:00