Abstract:
:The NF-κB signalling pathway plays an important role in controlling cellular immune responses, inflammation and apoptosis. In multiple sclerosis (MS), there is evidence of dysregulation of NF-κB signalling in patients with a relapsing-remitting disease course, but thus far there is little information on whether it is also dysregulated in patients with progressive disease. We hypothesised that patients with progressive MS would have more activation of NF-κB than relapsing-remitting MS patients. Using several different methods, we showed that there was more nuclear translocation of p65 in cells from progressive MS patients, particularly in T cells and monocytes. In addition, the amount of p65 translocated to the nucleus in cells of patients with progressive MS was not increased upon non-specific activation of the cells with the mitogen Con A. These results suggest that NF-κB dysregulation occurs in patients with progressive MS patients, as well as those with relapsing-remitting MS.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Yan J,Winterford CM,Catts VS,Pat BK,Pender MP,McCombe PA,Greer JMdoi
10.1016/j.jneuroim.2018.04.002subject
Has Abstractpub_date
2018-07-15 00:00:00pages
111-116eissn
0165-5728issn
1872-8421pii
S0165-5728(17)30536-2journal_volume
320pub_type
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