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Amelioration of CR-EAE with lisofylline: effects on mRNA levels of IL-12 and IFN-gamma in the CNS.

Abstract：

:CR-EAE is a Th1-mediated inflammatory autoimmune demyelinating disease of the CNS and serves as a model of human multiple sclerosis. Our previous studies have shown the protective effect of orally administered lisofylline in the prevention of active and passively induced acute EAE. In our present studies we have examined the efficacy and mechanism of action of lisofylline on CR-EAE. Lisofylline decreased the number and severity of paralytic attacks in mice with relapsing EAE. The reduction of clinical disease correlated with decreased levels of mRNA levels of IFN-gamma but not of mRNA levels of IL-12. These studies suggest that lisofylline may be an effective therapeutic for established Th1 mediated autoimmune disease and that it acts by blocking IL-12R signaling and not IL-12 production in vivo.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Du C,Cooper JC,Klaus SJ,Sriram S

doi

10.1016/s0165-5728(00)00348-9

subject

Has Abstract

pub_date

2000-10-02 00:00:00

pages

13-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(00)00348-9

journal_volume

110

pub_type

杂志文章

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