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Ischemic damage and early inflammatory infiltration are different in the core and penumbra lesions of rat brain after transient focal cerebral ischemia.

Abstract：

:Clinical and experimental observations emphasize that inflammation is a direct risk factor for stroke. We performed a detailed histological and immunohistochemical analysis, assisted by digital morphometry, to compare the representative brain lesions in the ischemic core and penumbra in a rat model. Focal neuronal necrosis and degeneration were significantly more intense in the core, whereas inflammatory infiltration, MPO, CD68, CD3, FXIII, Cox-2, iNOS2, Arg-1 expressions were stronger in the penumbra. Our findings indicate that neuroinflammation affects the penumbra more than the core and suggest that targeted modulation of the cellular infiltrate could be exploited to save brain volume.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Horváth E,Huțanu A,Chiriac L,Dobreanu M,Orădan A,Nagy EE

doi

10.1016/j.jneuroim.2018.08.002

subject

Has Abstract

pub_date

2018-11-15 00:00:00

pages

35-42

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(18)30225-X

journal_volume

324

pub_type

杂志文章

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