Changes in concentrations of tau-reactive antibodies are dependent on sex in Alzheimer's disease patients.

abstract：:We examined anti-complement C1q (C1q) autoantibody levels in serum and cerebrospinal fluid (CSF) samples of patients with neuromyelitis optica spectrum disorders (NMOSD). We analyzed the correlations between anti-C1q autoantibody levels and the clinical and other CSF characteristics of NMOSD. Serum and CSF anti-C1q au...

journal_title：Journal of neuroimmunology

authors： Yoshikura N,Kimura A,Hayashi Y,Inuzuka T

更新日期：2017-09-15 00:00:00

abstract：:Studies on patients with monosymptomatic optic neuritis (ON) should give opportunities to identify features typical for early multiple sclerosis (MS). There are increased T and B cell responses to the myelin components myelin basic protein (MBP) and proteolipid protein (PLP) in both ON and MS, but there is little info...

journal_title：Journal of neuroimmunology

authors： Link J,Söderström M,Kostulas V,Olsson T,Höjeberg B,Ljungdahl A,Link H

更新日期：1994-01-01 00:00:00

abstract：:Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing insulin tolerance t...

journal_title：Journal of neuroimmunology

authors： Drummond JB,Soares BS,Vieira ELM,Pedrosa W,Teixeira AL,Ribeiro-Oliveira A Jr

更新日期：2020-11-13 00:00:00

abstract：:Serum anti-GM1 IgA antibodies were detected in 15 of 53 (28%) patients with the acute Guillain-Barré syndrome (GBS) and in one of 26 (4%) patients with other neurological diseases. Although nine GBS patients had anti-GM1 IgA titers of 1:200 or less, six patients had titers of 1:800 or more. Some GBS patients with anti...

journal_title：Journal of neuroimmunology

authors： Ilyas AA,Mithen FA,Chen ZW,Cook SD

更新日期：1992-01-01 00:00:00

abstract：:Differences in the regulation of surface molecule expression and functional activity of microglia, the resident immune effector elements of the central nervous system (CNS), might give important insights into understanding the predilection sites of some diseases within the CNS. Therefore, canine microglial cells in re...

journal_title：Journal of neuroimmunology

authors： Ensinger EM,Boekhoff TM,Carlson R,Beineke A,Rohn K,Tipold A,Stein VM

更新日期：2010-10-08 00:00:00

abstract：:The cytotoxic effects of CD4+ P2-specific T-cell lines on Schwann cells were examined in vitro with 51Cr-release cytotoxicity assays. Only those P2-specific T-cell lines capable of inducing EAN when injected back into adult Lewis rats were cytotoxic to the Schwann cells. The addition of exogenous P2 protein was not ne...

journal_title：Journal of neuroimmunology

authors： Argall KG,Armati PJ,Pollard JD,Bonner J

更新日期：1992-09-01 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating autoimmune demyelinating disease of the central nervous system (CNS). This study investigated whether expression and activity of the calcium-activated protease calpain correlated with Th1/Th2 dysregulation in MS patients during states of relapse and remission. Calpain expressio...

journal_title：Journal of neuroimmunology

authors： Imam SA,Guyton MK,Haque A,Vandenbark A,Tyor WR,Ray SK,Banik NL

更新日期：2007-10-01 00:00:00

abstract：:Recombinant T cell ligands (RTLs) ameliorate experimental autoimmune encephalomyelitis (EAE) in an antigen-specific manner. We evaluated effects of RTL401 (I-A(s) alpha1beta1+PLP-139-151) on splenocytes from SJL/J mice with EAE to study RTL-T cell tolerance-inducing mechanisms. RTLs bound to B, macrophages and DCs, th...

journal_title：Journal of neuroimmunology

authors： Sinha S,Miller L,Subramanian S,McCarty OJ,Proctor T,Meza-Romero R,Huan J,Burrows GG,Vandenbark AA,Offner H

更新日期：2010-08-25 00:00:00

abstract：:A large body of immunologic, epidemiologic, and genetic data indicate that tissue injury in multiple sclerosis (MS) results from an abnormal immune response to one or more myelin antigens that develops in genetically susceptible individuals after exposure to an as-yet undefined causal agent. The genetic component of M...

journal_title：Journal of neuroimmunology

authors： Oksenberg JR,Baranzini SE,Barcellos LF,Hauser SL

更新日期：2001-02-15 00:00:00

abstract：:Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) has recently been identified as a potent antiviral protein. Here, we examined the expression and regulation of APOBEC3G in human brain tissues and the cells of central nervous system (CNS). Similar to the immune cells, human brain tissue an...

journal_title：Journal of neuroimmunology

authors： Wang YJ,Wang X,Zhang H,Zhou L,Liu S,Kolson DL,Song L,Ye L,Ho WZ

更新日期：2009-01-03 00:00:00

abstract：:Experimental autoimmune myasthenia gravis (EAMG) was induced in rats by injection of purified acetylcholine receptor (AChR). In addition to detecting elevated serum titers of anti-AChR antibodies, we observed decreased twitch-tension at submaximal stimulation voltages and increased curare sensitivity by muscles obtain...

journal_title：Journal of neuroimmunology

authors： Olsberg CA,Maxwell LC,Mikiten TM,Krolick KA

更新日期：1987-04-01 00:00:00

abstract：:To elucidate the possible involvement of the inducible nitric oxide synthase (iNOS) and NO in the development of lymphocytic choriomeningitis (LCM), the consequences of inhibition of iNOS by the inhibitor aminoguanidine was examined in mice following intracerebral infection with LCM virus (LCMV). Aminoguanidine admini...

journal_title：Journal of neuroimmunology

authors： Campbell IL

更新日期：1996-12-01 00:00:00

abstract：:Thymic tissues express transcripts encoding the alpha-3, alpha-5 and beta-4 subunits of nicotinic neuronal acetylcholine receptors (AcChRs) suggesting that neuronal AcChRs similar to those expressed in ganglia are expressed in the thymus. Transcription occurs in both isolated thymocytes and thymic epithelial cells. RT...

journal_title：Journal of neuroimmunology

authors： Mihovilovic M,Denning S,Mai Y,Whichard LP,Patel DD,Roses AD

更新日期：1997-11-01 00:00:00

abstract：:Human G-protein-coupled formyl peptide receptor-like 1 and its mouse homologue formyl peptide receptor 2 mediate the chemotactic activity of a variety of pathogen and host-derived peptides, including amyloid beta(42), a key causative factor in Alzheimer's disease (AD).Here, we found that polyinosine-polycytidylic acid...

journal_title：Journal of neuroimmunology

authors： Chen K,Huang J,Liu Y,Gong W,Cui Y,Wang JM

更新日期：2009-08-18 00:00:00

abstract：:We investigated potential therapeutic effects of sphingosine-1-phosphate (S1P) receptor modulators FTY720 (fingolimod) and selective S1P1 agonist SEW2871 on a spontaneous autoimmune polyneuropathy (SAP) when given orally at 7 mo (anticipated disease onset) for 4 weeks. Clinical severity, electrophysiologic and histolo...

journal_title：Journal of neuroimmunology

authors： Kim HJ,Jung CG,Dukala D,Bae H,Kakazu R,Wollmann R,Soliven B

更新日期：2009-09-29 00:00:00

abstract：:In multiple sclerosis, infiltrating T lymphocytes and perivascular microglia may initiate demyelinating lesions, but a role for antibody and complement in the ensuing inflammatory damage to myelin and oligodendrocytes is likely. In most tissues, ubiquitously expressed complement regulatory proteins prevent autologous ...

journal_title：Journal of neuroimmunology

authors： Scolding NJ,Morgan BP,Compston DA

更新日期：1998-04-01 00:00:00

abstract：:We evaluated the presence of soluble (s) CD4 and sCD8, released from activated T cells, in the sera of patients with multiple sclerosis (MS) and human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA). In addition, peripheral blood T cell subsets in pat...

journal_title：Journal of neuroimmunology

authors： Tsukada N,Matsuda M,Miyagi K,Yanagisawa N

更新日期：1991-12-01 00:00:00

abstract：:Paraneoplastic encephalomyelitis (PEM) is characterized by a diverse set of clinical signs that are limited to the nervous system. The serologic hallmark of PEM is the presence of circulating autoantibodies, collectively referred to as 'anti-Hu,' which immunoreact specifically with members of the Elav protein family. ...

journal_title：Journal of neuroimmunology

authors： Nabors LB,Furneaux HM,King PH

更新日期：1998-12-01 00:00:00

abstract：:Changes in mitogen-induced splenocyte proliferation and NK activity were evaluated after acute (1 h) and chronic (6 d) in vivo treatment of rats with the synthetic cannabinoid compound CP-55,940. At a dose of 0.4 mg/kg i.p. it significantly inhibited the splenocyte proliferative response to PHA and NK activity but hal...

journal_title：Journal of neuroimmunology

authors： Patrini G,Sacerdote P,Fuzio D,Manfredi B,Parolaro D

更新日期：1997-12-01 00:00:00

abstract：:The two D1-like dopamine receptor subtypes, D1a and D1b, are structurally similar and pharmacologically indistinguishable using currently available ligands. To differentiate between the D1-like dopamine receptor subtypes, murine monoclonal antibodies to the rat Dla and the rat D1b dopamine receptor have been prepared....

journal_title：Journal of neuroimmunology

authors： Luedtke RR,Griffin SA,Conroy SS,Jin X,Pinto A,Sesack SR

更新日期：1999-11-15 00:00:00

abstract：:We analyzed the characteristics of 29 Guillain-Barré syndrome (GBS) patients with IgM anti-GalNAc-GD1a antibodies. Fourteen of them had had an antecedent cytomegalovirus infection (CMV group) and 12 gastrointestinal infection (G-I group). Most of the G-I group patients (nine of 12) were subsequent to Campylobacter jej...

journal_title：Journal of neuroimmunology

authors： Kaida K,Kusunoki S,Kamakura K,Motoyoshi K,Kanazawa I

更新日期：2001-02-15 00:00:00

abstract：:The subunit composition of acetylcholine receptor-like protein(s) (AChR-LP) expressed by normal thymus was investigated. In skeletal muscle, the AChR exists in two forms, an embryonic form which contains the gamma-subunit and an adult form where the gamma-subunit is substituted by a different, homologous subunit calle...

journal_title：Journal of neuroimmunology

authors： Nelson S,Conti-Tronconi BM

更新日期：1990-09-01 00:00:00

abstract：:Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D. We analyzed the frequencies of two polymorphisms (codon 416 and codon 420) in the DBP gene through a case-control study involving 107 Japanese patients with multiple sclerosis (MS) and 109 heal...

journal_title：Journal of neuroimmunology

authors： Niino M,Kikuchi S,Fukazawa T,Yabe I,Tashiro K

更新日期：2002-06-01 00:00:00

abstract：:A B-cell activating factor of the tumor necrosis factor (TNF) family (BAFF) is an essential B-cell survival factor. Myasthenia gravis (MG) is one of the most typical antibody-mediated autoimmune disorders. To test whether serum BAFF levels are increased in MG patients, we compared the serum BAFF levels of 40 MG patien...

journal_title：Journal of neuroimmunology

authors： Kim JY,Yang Y,Moon JS,Lee EY,So SH,Lee HS,Park KD,Choi YC

更新日期：2008-08-13 00:00:00

abstract：:To determine the role of endogenous interleukin-18 (IL-18) in pneumococcal meningitis, meningitis was induced in IL-18 gene-deficient (IL-18(-/-)) and wild-type (WT) mice by intranasal inoculation of Streptococcus pneumoniae with hyaluronidase. Induction of meningitis resulted in an upregulation of both pro- and matur...

journal_title：Journal of neuroimmunology

authors： Zwijnenburg PJ,van der Poll T,Florquin S,Akira S,Takeda K,Roord JJ,van Furth AM

更新日期：2003-05-01 00:00:00

abstract：:In the present study, we investigated the B-cell translocation gene 1 (BTG1) as a candidate for multiple sclerosis (MS) susceptibility. BTG1 is a member of a family of genes involved in the apoptotic process. We genotyped two SNPs of the BTG1 gene (rs731652 and rs12694) in 550 MS patients and 548 controls. For SNP rs7...

journal_title：Journal of neuroimmunology

authors： Camiña-Tato M,Morcillo-Suárez C,Navarro A,Fernández M,Horga A,Montalban X,Comabella M

更新日期：2009-08-18 00:00:00

abstract：:To demonstrate the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP), we investigated the impact of a 6-month dietary supplementation with these fatty acids on the levels of interleukin-1 beta (IL-1 beta), IL-2, interferon-gam...

journal_title：Journal of neuroimmunology

authors： Gallai V,Sarchielli P,Trequattrini A,Franceschini M,Floridi A,Firenze C,Alberti A,Di Benedetto D,Stragliotto E

更新日期：1995-02-01 00:00:00

abstract：:Inflammation in the meninges, tissues surrounding the brain and spinal cord that enclose the cerebrospinal fluid, closely parallels clinical exacerbations in relapsing-remitting experimental autoimmune encephalomyelitis (EAE). In preclinical disease, an influx of innate immune cells precedes loss of blood brain barrie...

journal_title：Journal of neuroimmunology

authors： Walker-Caulfield ME,Hatfield JK,Brown MA

更新日期：2015-01-15 00:00:00

abstract：:Immunological events occurring in the central nervous system (CNS) as a result of head trauma are largely unexplored. We report here that the levels of the alternative pathway complement proteins C3 and factor B are elevated in the cerebrospinal fluid (CSF) of head-injured patients. C3 and factor B indices suggest tha...

journal_title：Journal of neuroimmunology

authors： Kossmann T,Stahel PF,Morganti-Kossmann MC,Jones JL,Barnum SR

更新日期：1997-03-01 00:00:00

abstract：:The extent to which symptomatic improvement in patients with multiple sclerosis treated with intravenous methylprednisolone depends on immunological actions of corticosteroids is unknown. In this study the effect of methylprednisolone on circulating T and B cell function has been assessed in vitro and in vivo. Low mol...

journal_title：Journal of neuroimmunology

authors： Kirk P,Compston A

更新日期：1990-01-01 00:00:00