Abstract:
:Major histocompatibility complex (MHC) class II molecules are expressed on myoblasts after interferon-gamma (IFN-gamma) treatment, suggesting a muscle cell involvement in antigen presentation in inflammatory myopathies. However, they were not observed on normal or pathological myofibers. This discrepancy might be related to different responsiveness of developmentally differentiated muscle cells to IFN-gamma. Myoblasts expressed class II transcripts and proteins after IFN-gamma, while myotubes and innervated contracting muscle cells did not show staining for class II molecules. At all cell stages no loss of IFN-gamma receptor was detected indicating that myofiber maturation blocks their capacity to express MHC class II molecules. This suggests that completely differentiated myofibers cannot participate in class II restricted immunological reactions.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Mantegazza R,Gebbia M,Mora M,Barresi R,Bernasconi P,Baggi F,Cornelio Fdoi
10.1016/0165-5728(96)00068-9subject
Has Abstractpub_date
1996-08-01 00:00:00pages
53-60issue
1-2eissn
0165-5728issn
1872-8421pii
0165-5728(96)00068-9journal_volume
68pub_type
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