Suppression of microglia activation after hypoxia-ischemia results in age-dependent improvements in neurologic injury.

abstract：:We evaluated the association of the plasma platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphism (G(994)-->T) and PAF-AH activity with susceptibility and severity of multiple sclerosis (MS) in Japanese. DNA was collected from 216 patients with clinically definite MS (65 opticospinal MS (OS-MS) and 151 ...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Niino M,Ochi H,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2004-05-01 00:00:00

abstract：:Early diagnosis of multiple sclerosis (MS) may be assisted by tests for the abnormal immune responses of the central nervous system (CNS) including oligoclonal IgG bands in the cerebrospinal fluid (CSF), increased CNS IgG synthesis, increased CNS antibody synthesis against multiple viruses and increased numbers of enl...

journal_title：Journal of neuroimmunology

authors： Iivanainen MV

更新日期：1981-06-01 00:00:00

abstract：:Emerging autoimmunity (epitope-spreading) generated as a consequence of myelin damage is suggested to underlie the relapses in multiple sclerosis (MS). Myelin oligodendrocyte glycoprotein (MOG 8-21) induces relapsing EAE in ABH mice characterized by broadening of the autoimmune reportoire. Despite epitope spreading to...

journal_title：Journal of neuroimmunology

authors： Smith PA,Morris-Downes M,Heijmans N,Pryce G,Arter E,O'Neill JK,'t Hart B,Baker D,Amor S

更新日期：2005-07-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disorder caused by antibody-mediated attack against skeletal muscle nicotinic acetylcholine receptor (AchR) at neuromuscular junction. A close relationship exists between heat shock proteins (HSPs) and numerous autoimmune diseases. HSPs are over expressed to protect the host aga...

journal_title：Journal of neuroimmunology

authors： Patil SA,Katyayani S,Sood A,Kavitha AK,Marimuthu P,Taly AB

更新日期：2013-04-15 00:00:00

abstract：:To find out whether rhesus macaque peripheral blood mononuclear cells (PBMCs) express mRNA for 5-HT receptors, blood samples from normal healthy rhesus monkeys were used to isolate PBMCs by Ficoll-paque density gradient centrifugation. Total RNA was extracted from MT-2 cells, Hut-78 cells, naive or phytohemagglutinin ...

journal_title：Journal of neuroimmunology

authors： Yang GB,Qiu CL,Zhao H,Liu Q,Shao Y

更新日期：2006-09-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to...

journal_title：Journal of neuroimmunology

authors： Conrady CD,Drevets DA,Carr DJ

更新日期：2010-03-30 00:00:00

abstract：:In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investi...

journal_title：Journal of neuroimmunology

authors： Peelen E,Thewissen M,Knippenberg S,Smolders J,Muris AH,Menheere P,Tervaert JW,Hupperts R,Damoiseaux J

更新日期：2013-05-15 00:00:00

abstract：:HIV-1 expression in monocytes/macrophages can be controlled by transforming growth factor-beta 1 (TGF-beta 1). TGF-beta 1 is present in astrocytes surrounding HIV-1-infected monocyte/macrophages in brain tissue from patients with AIDS but not from seronegative, normal individuals. We sought to determine whether or not...

journal_title：Journal of neuroimmunology

authors： da Cunha A,Jackson RW,Vitković L

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum disorders. METHODS:A HEK-293T transfected cell model expressing AQP1 was established and detected to be serum AQP1 antibodies. RESULTS:AQP1 a...

journal_title：Journal of neuroimmunology

authors： Long Y,Zheng Y,Shan F,Chen M,Fan Y,Zhang B,Gao C,Gao Q,Yang N

更新日期：2014-08-15 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is a severe neurological disease characterized by progressive demyelination within the CNS, adrenal insufficiency, and is associated with an accumulation of saturated very long chain fatty acids in plasma and tissues of patients. iNKT cells, a distinct lineage of T cells recognizi...

journal_title：Journal of neuroimmunology

authors： Gautron AS,Giquel B,Beaudoin L,Autrusseau E,Speak A,Platt F,Kemp S,Pujol A,Aubourg P,Lehuen A

更新日期：2010-12-15 00:00:00

abstract：:Current immunotherapy of myasthenia gravis (MG) is often effective, but entails risks of infection and neoplasia. The "Guided Missile" strategy described here is designed to target and eliminate the individual's unique AChR-specific T cell repertoire, without otherwise interfering with the immune system. We geneticall...

journal_title：Journal of neuroimmunology

authors： Sun W,Adams RN,Miagkov A,Lu Y,Juon HS,Drachman DB

更新日期：2012-10-15 00:00:00

abstract：:We examined immune function and changes in T cell populations over a 1-year period in a series of progressive multiple sclerosis (MS) patients treated with different regimens of cyclophosphamide/ACTH as part of the Northeast Multiple Sclerosis Treatment Group. Our studies were designed to determine the effect of diffe...

journal_title：Journal of neuroimmunology

authors： Hafler DA,Orav J,Gertz R,Stazzone L,Weiner HL

更新日期：1991-05-01 00:00:00

abstract：:In the present work we investigated on rat splenocytes long-term interactions between opioid and cannabinoid drugs in terms of a common regulation of cAMP intracellular pathway. Both morphine and the synthetic cannabinoid compound CP-55,940 inhibited in a concentration-dependent manner the intracellular cAMP level in ...

journal_title：Journal of neuroimmunology

authors： Massi P,Vaccani A,Rubino T,Parolaro D

更新日期：2003-12-01 00:00:00

abstract：:Recent evidence that astrocytes can be induced to express the class II major histocompatability (MHC) antigens suggests that these cells may be involved in the development of intracerebral immune responses. The principal inducer of MHC class II antigen (Ia) expression is a soluble lymphokine, gamma-interferon (gamma-I...

journal_title：Journal of neuroimmunology

authors： Frohman EM,Vayuvegula B,van den Noort S,Gupta S

更新日期：1988-01-01 00:00:00

abstract：:Enzymatically derived nitric oxide (NO) has been implicated in numerous physiological and pathological processes in the brain. Whereas during development NO participates in developmental and maturation processes, excess NO production in the adult in response to inflammation, injury, or trauma participates in both cell...

journal_title：Journal of neuroimmunology

authors： Heneka MT,Feinstein DL

更新日期：2001-03-01 00:00:00

abstract：:Human sera from patients with multiple sclerosis (MS) were tested using an enzyme-linked immunosorbent assay (ELISA) method on well plates coated with various dicarboxylic acid (C4 to C10) protein conjugates. Specific immunological binding was found with an azelaic acid (AzeA, C9) conjugate. The antibody titer was hig...

journal_title：Journal of neuroimmunology

authors： Daverat P,Geffard M,Orgogozo JM

更新日期：1989-04-01 00:00:00

abstract：:Immunofluorescence, cell binding assays and enzyme immunoassays were used to investigate the expression of class II major histocompatibility antigens on peripheral blood monocytes in 67 patients with multiple sclerosis. Monocytes from patients with active disease expressed fewer HLA-DR molecules on their surface than ...

journal_title：Journal of neuroimmunology

authors： Baxevanis CN,Reclos GJ,Arsenis P,Anastasopoulos E,Katsiyiannis A,Lymberi P,Matikas N,Papamichail M

更新日期：1989-05-01 00:00:00

abstract：:Inflammation and immune response play a pivotal role in the pathophysiology of ischemic stroke giving their contribution to tissue damage and repair. Emerging evidence supports the involvement of epigenetic mechanisms such as methylation, histone modification and miRNAs in the pathogenesis of stroke. Interestingly, ep...

journal_title：Journal of neuroimmunology

authors： Picascia A,Grimaldi V,Iannone C,Soricelli A,Napoli C

更新日期：2015-12-15 00:00:00

abstract：:The role of cell surface tyrosine kinase collagen-activated receptors known as discoidin domain receptors (DDRs) is unknown in neurodegenerative diseases. We detect up-regulation in DDRs level in post-mortem Alzheimer and Parkinson brains. Lentiviral shRNA knockdown of DDR1 and DDR2 reduces the levels of α-synuclein, ...

journal_title：Journal of neuroimmunology

authors： Hebron M,Peyton M,Liu X,Gao X,Wang R,Lonskaya I,Moussa CE

更新日期：2017-10-15 00:00:00

abstract：:A large body of immunologic, epidemiologic, and genetic data indicate that tissue injury in multiple sclerosis (MS) results from an abnormal immune response to one or more myelin antigens that develops in genetically susceptible individuals after exposure to an as-yet undefined causal agent. The genetic component of M...

journal_title：Journal of neuroimmunology

authors： Oksenberg JR,Baranzini SE,Barcellos LF,Hauser SL

更新日期：2001-02-15 00:00:00

abstract：:In order to screen the Turkish population for evidence of association with multiple sclerosis, we typed 6000 microsatellite markers in separately pooled DNA samples from 197 cases and 199 controls following the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) protocol. Twelve markers showing evidence for as...

journal_title：Journal of neuroimmunology

authors： Eraksoy M,Hensiek A,Kurtuncu M,Akman-Demir G,Kilinc M,Gedizlioglu M,Petek-Balci B,Anlar O,Kutlu C,Saruhan-Direskeneli G,Idrisoglu HA,Setakis E,Compston A,Sawcer S,Turkish Multiple Sclerosis Genetics Study Group.

更新日期：2003-10-01 00:00:00

abstract：:The subunit composition of acetylcholine receptor-like protein(s) (AChR-LP) expressed by normal thymus was investigated. In skeletal muscle, the AChR exists in two forms, an embryonic form which contains the gamma-subunit and an adult form where the gamma-subunit is substituted by a different, homologous subunit calle...

journal_title：Journal of neuroimmunology

authors： Nelson S,Conti-Tronconi BM

更新日期：1990-09-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we gen...

journal_title：Journal of neuroimmunology

authors： Lorentzen AR,Melum E,Ellinghaus E,Smestad C,Mero IL,Aarseth JH,Myhr KM,Celius EG,Lie BA,Karlsen TH,Franke A,Harbo HF

更新日期：2010-09-14 00:00:00

abstract：:Serotonin transporter sites were characterized in blood lymphocytes of rats. Pharmacological characteristics of drug interactions were in concordance with recent studies in nervous and human immune cells. The potency order of inhibition of [(3)H]paroxetine binding was imipramine>citalopram>alaproclate>serotonin. Selec...

journal_title：Journal of neuroimmunology

authors： Cedeño N,Urbina M,Obregón F,Lima L

更新日期：2005-02-01 00:00:00

abstract：:Large-scale genome-wide association study (GWAS) datasets provide strong support for investigations of the mechanisms underlying multiple sclerosis (MS) by using pathway analysis methods. In our recent study, we conducted a three-stage pathway analysis of GWAS and expression datasets. After identifying 15 shared MS pa...

journal_title：Journal of neuroimmunology

authors： Liu G,Zhang F,Hu Y,Jiang Y,Gong Z,Liu S,Chen X,Jiang Q,Hao J

更新日期：2017-06-15 00:00:00

abstract：:Inflammatory reactions in the CNS, resulting from a loss of control and involving a network of non-neuronal and neuronal cells, are major contributors to the onset and progress of several major neurodegenerative diseases. Therapeutic strategies should therefore keep or restore the well-controlled and finely-tuned bala...

journal_title：Journal of neuroimmunology

authors： Häke I,Schönenberger S,Neumann J,Franke K,Paulsen-Merker K,Reymann K,Ismail G,Bin Din L,Said IM,Latiff A,Wessjohann L,Zipp F,Ullrich O

更新日期：2009-01-03 00:00:00

abstract：:The presence of muscarinic acetylcholine receptors on lymphocytes has been demonstrated by radioligand binding experiments. Although the specific subtype(s) of muscarinic acetylcholine receptors expressed in lymphocytes is still unknown, some reports suggest the presence of the m2 subtype. In this study we analyzed th...

journal_title：Journal of neuroimmunology

authors： Costa P,Castoldi AF,Traver DJ,Costa LG

更新日期：1994-01-01 00:00:00

abstract：:Omega-3 polyunsaturated fatty acids (PUFA n3) provide neuroprotection due to their anti-inflammatory and anti-apoptotic properties as well as their regulatory function on growth factors and neuronal plasticity. These qualities enable PUFA n3 to ameliorate stroke outcome and limit neuronal damage. Young adult male rats...

journal_title：Journal of neuroimmunology

authors： Zendedel A,Habib P,Dang J,Lammerding L,Hoffmann S,Beyer C,Slowik A

更新日期：2015-01-15 00:00:00

abstract：:Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. This study investigated GLE preventive effects on LPS-stimulated inflammation of BV-2 microglial cells. The results show that pre-treatment with GLE decreased expression of pro-inflammatory cytokines: G-CSF, IL1-α, ...

journal_title：Journal of neuroimmunology

authors： Hilliard A,Mendonca P,Soliman KFA

更新日期：2020-08-15 00:00:00

abstract：:Recent evidence emphasises a pivotal role for dendritic cells (DC) in the control of immunity by priming and tolerising T cells. DC capture and process antigens, express co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. In multiple sclerosis (MS), autoreactive T c...

journal_title：Journal of neuroimmunology

authors： Huang YM,Xiao BG,Ozenci V,Kouwenhoven M,Teleshova N,Fredrikson S,Link H

更新日期：1999-09-01 00:00:00