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Development of a cell-based assay for the detection of anti-aquaporin 1 antibodies in neuromyelitis optica spectrum disorders.

Abstract：

OBJECTIVE:To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum disorders. METHODS:A HEK-293T transfected cell model expressing AQP1 was established and detected to be serum AQP1 antibodies. RESULTS:AQP1 antibodies were present in 73/98 (74.5%) AQP4 antibody-positive patients. Some AQP4 antibody-negative patients were also AQP1 antibody-positive. Test sensitivity was 74.5% in 98 AQP4 antibody-positive patients. Test specificity was 79.6% in 67 multiple sclerosis (MS) patients and 31 controls. CONCLUSION:A sensitive and simple CBA was developed to detect serum AQP1 antibodies. AQP1 antibodies were mainly present in NMO and its high-risk syndrome, but also in some MS patients.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Long Y,Zheng Y,Shan F,Chen M,Fan Y,Zhang B,Gao C,Gao Q,Yang N

doi

10.1016/j.jneuroim.2014.06.003

subject

Has Abstract

pub_date

2014-08-15 00:00:00

pages

103-10

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(14)00174-X

journal_volume

273

pub_type

杂志文章

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