Immune reactive C3d on the surface of myelin sheaths in neuropathy.

abstract：:Strong expression of class II major histocompatibility (MHC II, Ia) antigens was observed in areas of Wallerian degeneration following either a cryoinjury to the cerebral and cerebellar cortex or unilateral eye enucleation in adult Wistar and Lewis rats. The Wallerian degeneration was disclosed by the Fink-Heimer meth...

journal_title：Journal of neuroimmunology

authors： Konno H,Yamamoto T,Iwasaki Y,Suzuki H,Saito T,Terunuma H

更新日期：1989-12-01 00:00:00

abstract：:Neurological damage caused by intoxication with Shiga toxin (Stx) from enterohemorrhagic Escherichia coli is the most unrepairable and untreatable outcome of Hemolytic Uremic Syndrome, and occurs in 30% of affected infants. In this work intracerebroventricular administration of Stx2 in rat brains significantly increas...

journal_title：Journal of neuroimmunology

authors： Tironi-Farinati C,Loidl CF,Boccoli J,Parma Y,Fernandez-Miyakawa ME,Goldstein J

更新日期：2010-05-01 00:00:00

abstract：:Insulin-like growth factor-2 (IGF-2) present in media conditioned by non-activated and interferon gamma (IFN gamma)-treated microglia reduces galactocerebroside(+) (GalC) oligodendrocyte apoptosis in cultures derived both from the CG4 cell line and primary rat cortices. Microglia-derived IGF-2 also acts in each cultur...

journal_title：Journal of neuroimmunology

authors： Nicholas RS,Stevens S,Wing MG,Compston DA

更新日期：2002-03-01 00:00:00

abstract：:Antisera raised to the astrocyte intermediate filament structural protein stained elements in the peripheral nerves of several species. These elements were not associated with myelinated nerve fibers, were more common in splenic and vagus nerves than in the sciatic nerve, and persisted after nerve transection. In teas...

journal_title：Journal of neuroimmunology

authors： Fields KL,Yen SH

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum disorders. METHODS:A HEK-293T transfected cell model expressing AQP1 was established and detected to be serum AQP1 antibodies. RESULTS:AQP1 a...

journal_title：Journal of neuroimmunology

authors： Long Y,Zheng Y,Shan F,Chen M,Fan Y,Zhang B,Gao C,Gao Q,Yang N

更新日期：2014-08-15 00:00:00

abstract：:We investigated the role of IFN-gamma activated microglia in the passage of T lymphocytes across a monolayer of brain endothelial cells (EC) in vitro. Microglia isolated from Fisher 344 (F344) newborn rats were stimulated with IFN-gamma (100 U/ml) for 48 h. T lymphocytes primed with glioma cells were 51Cr-labeled, and...

journal_title：Journal of neuroimmunology

authors： Watanabe T,Tanaka R,Taniguchi Y,Yamamoto K,Ono K,Yoshida S

更新日期：1998-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healt...

journal_title：Journal of neuroimmunology

authors： Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

更新日期：2004-01-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with myelin basic protein (MBP) and adjuvants. Rats were treated with second daily injections of saline or cyclosporin A (CsA) from the day of inoculation. Saline-treated rats had an acute episode of disease followed by clinical r...

journal_title：Journal of neuroimmunology

authors： McCombe PA,Harness J,Pender MP

更新日期：1999-06-01 00:00:00

abstract：:T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99...

journal_title：Journal of neuroimmunology

authors： Bourdette DN,Vandenbark AA,Hashim G,Whitham RH,Offner H

更新日期：1989-05-01 00:00:00

abstract：:In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-five days after EAE induction, blood, spinal cord and brain stem were used for histological examin...

journal_title：Journal of neuroimmunology

authors： Micera A,Properzi F,Triaca V,Aloe L

更新日期：2000-05-01 00:00:00

abstract：:Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We o...

journal_title：Journal of neuroimmunology

authors： García-Pérez D,Luisa Laorden M,Núñez C,Victoria Milanés M

更新日期：2014-09-15 00:00:00

abstract：:M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS or IFN-gamma induce a M1-like phenotype, while IL-10 or IL-4 differe...

journal_title：Journal of neuroimmunology

authors： Michelucci A,Heurtaux T,Grandbarbe L,Morga E,Heuschling P

更新日期：2009-05-29 00:00:00

abstract：:Cytokines such as interleukin-1 (IL-1) are thought to contribute to the inflammatory response associated with autoimmune diseases like multiple sclerosis. We assessed the role of IL-1 in an animal model of MS, experimental allergic encephalomyelitis (EAE), by testing the effects of treatment with an IL-1 receptor anta...

journal_title：Journal of neuroimmunology

authors： Martin D,Near SL

更新日期：1995-09-01 00:00:00

abstract：:Lactogen-dependent Nb2 cell lines have been widely employed to investigate signaling mechanisms coupled to prolactin receptor (PRLR)-stimulated transcription of hormone-responsive genes. We previously reported that PRL rapidly induced expression of the immediate-early protooncogene, pim-1. In the present report, we de...

journal_title：Journal of neuroimmunology

authors： Buckley AR

更新日期：2000-09-01 00:00:00

abstract：:A rare case of neuromyelitis optica spectrum disorder, suspected to be bacterial meningomyelitis as the initial manifestation, is reported. The patient presented with initial symptoms of meningomyelitis and fever. Cerebrospinal fluid analysis revealed pleocytosis (1280×106/L [98% lymphocytes]) and glucose level of 1.8...

journal_title：Journal of neuroimmunology

authors： Li X,Lin J,Pan S,Weng Y,Li J,Zhang X,Xia J,Tong Q

更新日期：2017-08-15 00:00:00

abstract：:Aberrant activation of calpain plays a key role in the pathophysiology of several neurodegenerative disorders. Calpain is increasingly expressed in inflammatory cells in EAE and is significantly elevated in the white matter of patients with multiple sclerosis, thus calpain inhibition could be a target for therapeutic ...

journal_title：Journal of neuroimmunology

authors： Hassen GW,Feliberti J,Kesner L,Stracher A,Mokhtarian F

更新日期：2006-11-01 00:00:00

abstract：:We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, th...

journal_title：Journal of neuroimmunology

authors： Bracci-Laudiero L,Aloe L,Buanne P,Finn A,Stenfors C,Vigneti E,Theodorsson E,Lundeberg T

更新日期：2002-02-01 00:00:00

abstract：:The key role of an inhibitory receptor, Programmed Death-1, has been evaluated in 273 patients with autoimmune myasthenia gravis. At the genetic level, SNP's genotyping showed no significant association to the disease. Gene expressions in patients were not different from that in controls. Interestingly, at the cell-su...

journal_title：Journal of neuroimmunology

authors： Sakthivel P,Ramanujam R,Wang XB,Pirskanen R,Lefvert AK

更新日期：2008-01-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) is used in the treatment of a variety of autoimmune diseases. The blocking of disease-associated antibodies by anti-idiotype antibodies present in IVIg has been proposed as an action mechanism. Anti-GM1 antibodies have been implicated in motor neuropathies. Although IVIg is frequently...

journal_title：Journal of neuroimmunology

authors： Lopez PH,Irazoqui FJ,Nores GA

更新日期：2000-06-26 00:00:00

abstract：:Following axotomy of the facial nerve microglial cells in the facial nucleus become activated, proliferate, and newly express class I and class II major histocompatibility complex (MHC) antigens. Dexamethasone treatment, starting 2 days prior to axotomy at 1 mg/kg/day, selectively inhibited axotomy-induced MHC class I...

journal_title：Journal of neuroimmunology

authors： Kiefer R,Kreutzberg GW

更新日期：1991-11-01 00:00:00

abstract：:We investigated T cell epitopes of guinea pig myelin basic protein (MBP) that induce experimental autoimmune encephalomyelitis (EAE) in DA rats, using synthetic peptides that correspond to regions of the guinea pig MBP molecule that are homologous to rat MBP. Four peptides were encephalitogenic when tested in DA rats....

journal_title：Journal of neuroimmunology

authors： Stepaniak JA,Wolf NA,Sun D,Swanborg RH

更新日期：1997-09-01 00:00:00

abstract：:Aspects of gene-environment interactions in multiple sclerosis (MS) were analysed in serum samples from 46 MS families (25 sporadic MS cases and 42 familial MS cases): antibodies to the MS-associated human endogenous retrovirus HERV-H, and levels of three components in the innate pathogen-associated molecular pattern ...

journal_title：Journal of neuroimmunology

authors： Christensen T,Petersen T,Thiel S,Brudek T,Ellermann-Eriksen S,Møller-Larsen A

更新日期：2007-02-01 00:00:00

abstract：:Bacterial meningitis is - despite therapeutical progress during the last decades - still characterized by high mortality and severe permanent neurogical sequelae. The brain is protected from penetrating pathogens by both the blood-brain barrier and the innate immune system. Invading pathogens are recognized by so-call...

journal_title：Journal of neuroimmunology

authors： Böhland M,Kress E,Stope MB,Pufe T,Tauber SC,Brandenburg LO

更新日期：2016-10-15 00:00:00

abstract：:The capacity of three different human glioblastoma cell lines to activate human T cells was analysed by measuring major histocompatibility complex (MHC) antigen expression, monokine secretion and lectin, mAb OKT3 and antigen-driven T cell proliferation. All glioblastoma cells tested were able to induce PHA and concana...

journal_title：Journal of neuroimmunology

authors： Däubener W,Zennati SS,Wernet P,Bilzer T,Fischer HG,Hadding U

更新日期：1992-11-01 00:00:00

abstract：:In this study, percentages of CD39(+) Treg and Th17 cells were compared between relapsing-remitting MS patients and controls and were related to the vitamin D status. The Th17 cell population was expanded in about 40% of the MS patients. In MS patients in remission, but not during relapse, a positive association was f...

journal_title：Journal of neuroimmunology

authors： Peelen E,Damoiseaux J,Smolders J,Knippenberg S,Menheere P,Tervaert JW,Hupperts R,Thewissen M

更新日期：2011-12-15 00:00:00

abstract：:Sprague-Dawley male rats implanted with chronic indwelling cannulae at the perifornical hypothalamus eat excessively during the sixth hour following administration of exogenous immune-complexing reactants to the brain site. Rabbit anti-HSA was injected, followed in 30 min by a 20-fold excess of antigen. Anaphylatoxin ...

journal_title：Journal of neuroimmunology

authors： Schupf N,Williams CA

更新日期：1987-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is emerging as an important modulator of the function of the central nervous system. In the present study, we investigated a role of endogenous TNF-alpha in cognitive and emotional function using mice with targeted deletions of the TNF-alpha gene. TNF-alpha-(-/-) mice showed nor...

journal_title：Journal of neuroimmunology

authors： Yamada K,Iida R,Miyamoto Y,Saito K,Sekikawa K,Seishima M,Nabeshima T

更新日期：2000-11-01 00:00:00

abstract：:The role of cell surface tyrosine kinase collagen-activated receptors known as discoidin domain receptors (DDRs) is unknown in neurodegenerative diseases. We detect up-regulation in DDRs level in post-mortem Alzheimer and Parkinson brains. Lentiviral shRNA knockdown of DDR1 and DDR2 reduces the levels of α-synuclein, ...

journal_title：Journal of neuroimmunology

authors： Hebron M,Peyton M,Liu X,Gao X,Wang R,Lonskaya I,Moussa CE

更新日期：2017-10-15 00:00:00

abstract：:T-cell subsets in the peripheral blood were analyzed using monoclonal antibodies during the development of experimental allergic neuritis in Lewis rats. Percentages of helper and suppressor cells and ratios of helper/suppressor cells did not exceed normal limits during the development of the disease. ...

journal_title：Journal of neuroimmunology

authors： Feasby TE,Mazaheri R,Hahn AF,Gilbert JJ,Stiller CR,Keown PA

更新日期：1984-06-01 00:00:00

abstract：:Experimental autoimmune myasthenia gravis (EAMG) was induced in rats by injection of purified acetylcholine receptor (AChR). In addition to detecting elevated serum titers of anti-AChR antibodies, we observed decreased twitch-tension at submaximal stimulation voltages and increased curare sensitivity by muscles obtain...

journal_title：Journal of neuroimmunology

authors： Olsberg CA,Maxwell LC,Mikiten TM,Krolick KA

更新日期：1987-04-01 00:00:00