Abstract:
:In this study, percentages of CD39(+) Treg and Th17 cells were compared between relapsing-remitting MS patients and controls and were related to the vitamin D status. The Th17 cell population was expanded in about 40% of the MS patients. In MS patients in remission, but not during relapse, a positive association was found between Th17 cell and CD39(+) Treg percentages (r=0.468, p=0.007). Since CD39(+) Tregs have been shown to have Th17 suppressive capacities, we propose that a dysregulated Th17/CD39(+) Treg balance might contribute to disease exacerbation. A clear role for vitamin D in this regulation could not be established.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Peelen E,Damoiseaux J,Smolders J,Knippenberg S,Menheere P,Tervaert JW,Hupperts R,Thewissen Mdoi
10.1016/j.jneuroim.2011.09.013subject
Has Abstractpub_date
2011-12-15 00:00:00pages
97-103eissn
0165-5728issn
1872-8421pii
S0165-5728(11)00266-9journal_volume
240-241pub_type
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journal_title:Journal of neuroimmunology
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