Tumour necrosis factor-alpha polymorphism and secretion in myasthenia gravis.

abstract：:Screening with a 7-mer phage display peptide library, a panel of cell-targeting peptides for the murine microglial cell line, EOC 20, was recognized. A number of similar, but not identical, sets of sequences representing more than 75% of all the cell line-binding clones were identified. Comparative analysis indicated ...

journal_title：Journal of neuroimmunology

authors： Samoylova TI,Ahmed BY,Vodyanoy V,Morrison NE,Samoylov AM,Globa LP,Baker HJ,Cox NR

更新日期：2002-06-01 00:00:00

abstract：:Intrathecal Immunoglobulin G (IgG) is elevated in some central nervous system (CNS) diseases and microglia upregulate Fcγ receptors in various neurological disorders. However, the interaction between IgG or IgG immune complexes and microglial Fcγ receptors is not fully understood. In this study, the effect of IgG(1) i...

journal_title：Journal of neuroimmunology

authors： Parajuli B,Sonobe Y,Kawanokuchi J,Doi Y,Noda M,Takeuchi H,Mizuno T,Suzumura A

更新日期：2012-03-01 00:00:00

abstract：:Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compa...

journal_title：Journal of neuroimmunology

authors： Calabresi PA,Yun SH,Allie R,Whartenby KA

更新日期：2002-06-01 00:00:00

abstract：:Vitamin D-binding protein (DBP) is known to function as an immunomodulatory factor, as well as the main carrier of vitamin D. We analyzed the frequencies of two polymorphisms (codon 416 and codon 420) in the DBP gene through a case-control study involving 107 Japanese patients with multiple sclerosis (MS) and 109 heal...

journal_title：Journal of neuroimmunology

authors： Niino M,Kikuchi S,Fukazawa T,Yabe I,Tashiro K

更新日期：2002-06-01 00:00:00

abstract：:Functional studies of cerebrospinal fluid T lymphocytes during acute viral infections of the nervous system are rare. Recently, we had the opportunity to investigate the requirements for interferon-gamma (IFN-gamma) production of human in vivo activated (primary) cytotoxic T lymphocytes (CTL) generated during acute vi...

journal_title：Journal of neuroimmunology

authors： Martin R,Vallbracht A,Kreth HW

更新日期：1991-09-01 00:00:00

abstract：:To assess the immunopathological significance of the increased replication of human T-cell leukemia virus type I (HTLV-I) in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) we investigated the dynamics of HTLV-I proviral DNA in peripheral blood mononuclear cells (PBMC) of HAM/TSP patients at differ...

journal_title：Journal of neuroimmunology

authors： Kubota R,Fujiyoshi T,Izumo S,Yashiki S,Maruyama I,Osame M,Sonoda S

更新日期：1993-02-01 00:00:00

abstract：:A B-cell activating factor of the tumor necrosis factor (TNF) family (BAFF) is an essential B-cell survival factor. Myasthenia gravis (MG) is one of the most typical antibody-mediated autoimmune disorders. To test whether serum BAFF levels are increased in MG patients, we compared the serum BAFF levels of 40 MG patien...

journal_title：Journal of neuroimmunology

authors： Kim JY,Yang Y,Moon JS,Lee EY,So SH,Lee HS,Park KD,Choi YC

更新日期：2008-08-13 00:00:00

abstract：:This study examined the mechanism by which exposure to lipopolysaccharide (LPS) alters mu-opioid receptor (MOR) expression in immune and neuronal cells using an in vitro conditioned medium model system. We found that LPS stimulated the intracellular accumulation of reactive oxygen species (ROS) and MOR expression in m...

journal_title：Journal of neuroimmunology

authors： Langsdorf EF,Mao X,Chang SL

更新日期：2011-07-01 00:00:00

abstract：:Chitin is an insoluble N-acetyl-glucosamine polymer coating fungi cell wall and several human parasites. It is hydrolysed by chitotriosidase (Chit); however, as chitin is absent in humans, the significance of human Chit activity is unknown. The level of plasma Chit activity positively correlates with Alzheimer's disea...

journal_title：Journal of neuroimmunology

authors： Sotgiu S,Musumeci S,Marconi S,Gini B,Bonetti B

更新日期：2008-06-15 00:00:00

abstract：:Immunization with the whole cell pertussis vaccine (Pw), but not the acellular pertussis vaccine (Pa), is associated with a number of neurological side effects. Previously, we have demonstrated a role for interleukin-1beta (IL-1beta) in Pw reactogenicity. Here we report that parenteral Pw administration resulted in a ...

journal_title：Journal of neuroimmunology

authors： Armstrong ME,Loscher CE,Lynch MA,Mills KH

更新日期：2003-03-01 00:00:00

abstract：:An epistatic gene interaction has been advocated to explain disease susceptibility in multiple sclerosis (MS). Cytokine genes are possible candidates due to the central role played by cytokines in the regulation of the immune-mediated pathogenetic process leading to central nervous system demyelination in these patien...

journal_title：Journal of neuroimmunology

authors： Vandenbroeck K,Martino G,Marrosu M,Consiglio A,Zaffaroni M,Vaccargiu S,Franciotta D,Ruggeri M,Comi G,Grimaldi LM

更新日期：1997-06-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). To better understand the mechanism of disease relapse, we induced acute and chronic ...

journal_title：Journal of neuroimmunology

authors： Jee Y,Yoon WK,Okura Y,Tanuma N,Matsumoto Y

更新日期：2002-07-01 00:00:00

abstract：:Muscle weakness in MuSK myasthenia gravis (MG) is caused predominantly by IgG4 antibodies which block MuSK signalling and destabilize neuromuscular junctions. We determined whether the binding pattern of MuSK IgG4 antibodies change throughout the disease course ("epitope spreading"), and affect disease severity or tre...

journal_title：Journal of neuroimmunology

authors： Huijbers MG,Vink AF,Niks EH,Westhuis RH,van Zwet EW,de Meel RH,Rojas-García R,Díaz-Manera J,Kuks JB,Klooster R,Straasheijm K,Evoli A,Illa I,van der Maarel SM,Verschuuren JJ

更新日期：2016-02-15 00:00:00

abstract：:Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF...

journal_title：Journal of neuroimmunology

authors： Bo M,Niegowska M,Arru G,Sechi E,Mariotto S,Mancinelli C,Farinazzo A,Alberti D,Gajofatto A,Ferrari S,Capra R,Monaco S,Sechi G,Sechi LA

更新日期：2018-05-15 00:00:00

abstract：:Bi-directional interactions between the central nervous system (CNS) and immune system are demonstrated by the modification of immune function using behavioral conditioning. However, the mechanisms by which the CNS achieves conditioned immunomodulation are still in question. Here, we report that the immunosuppressive ...

journal_title：Journal of neuroimmunology

authors： Exton MS,von Hörsten S,Schult M,Vöge J,Strubel T,Donath S,Steinmüller C,Seeliger H,Nagel E,Westermann J,Schedlowski M

更新日期：1998-08-01 00:00:00

abstract：:Mutations in the GBA gene are related to an increased risk of developing neurodegenerative diseases. The exact molecular mechanisms involved in the interaction between GBA and α-synuclein, a protein that has been associated with several neurological diseases, remain unsolved. Brain-derived neurotrophic factor (BDNF) i...

journal_title：Journal of neuroimmunology

authors： Vairo F,Sperb-Ludwig F,Wilke M,Michellin-Tirelli K,Netto C,Neto EC,Doederlein Schwartz IV

更新日期：2015-01-15 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic inflammatory myelopathy. The pathophysiology of HAM/TSP is not yet fully understood; therefore, effective therapy remains a challenging issue. This study was designed to evaluate the efficacy of interfe...

journal_title：Journal of neuroimmunology

authors： Rafatpanah H,Rezaee A,Etemadi MM,Hosseini RF,Khorram B,Afsahr L,Taylor G,Mokhber N,Mahmoudi M,Abbaszadegan MR,Foroghipor M,Hashemi P,Amiri A,Tehrani M,Azarpazhooh A,Azarpazhooh MR

更新日期：2012-09-15 00:00:00

abstract：:We measured circulating serum and cerebrospinal fluid (CSF) concentrations of B lymphocyte activating factor of the tumour necrosis factor superfamily (BAFF), and determined total and Epstein-Barr virus (EBV)-specific oligoclonal IgG bands (OCBs) in 43 patients with multiple sclerosis (MS), 23 patients with other infl...

journal_title：Journal of neuroimmunology

authors： Franciotta D,Di Stefano AL,Jarius S,Zardini E,Tavazzi E,Ballerini C,Marchioni E,Bergamaschi R,Ceroni M

更新日期：2011-01-01 00:00:00

abstract：:The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. Howe...

journal_title：Journal of neuroimmunology

authors： Jilek S,Kuhle J,Meylan P,Reichhart MD,Pantaleo G,Du Pasquier RA

更新日期：2007-12-01 00:00:00

abstract：:In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-β and natalizumab. Our data show that the...

journal_title：Journal of neuroimmunology

authors： Rovituso D,Heller S,Schroeter M,Kleinschnitz C,Kuerten S

更新日期：2014-07-15 00:00:00

abstract：:A significant skewing of the peripheral T cell repertoire has been shown in relapsing-remitting multiple sclerosis (MS). Most of the studies already performed in this field are cross-sectional and therefore, little is known of the T cell repertoire evolution over time in MS and the correlation of T cell repertoire var...

journal_title：Journal of neuroimmunology

authors： Laplaud DA,Berthelot L,Miqueu P,Bourcier K,Moynard J,Oudinet Y,Guillet M,Ruiz C,Oden N,Brouard S,Guttmann CR,Weiner HL,Khoury SJ,Soulillou JP

更新日期：2006-08-01 00:00:00

abstract：:Previous work in our laboratory has shown that cytokine production by primary murine macrophages, and macrophage cell lines, is inhibited following treatment with the kappa-opioid agonist U50,488H. Furthermore, we have found that the participation of both accessory cells and T cells in an antibody response is suppress...

journal_title：Journal of neuroimmunology

authors： Guan L,Eisenstein TK,Adler MW,Rogers TJ

更新日期：1997-05-01 00:00:00

abstract：:Strong expression of class II major histocompatibility (MHC II, Ia) antigens was observed in areas of Wallerian degeneration following either a cryoinjury to the cerebral and cerebellar cortex or unilateral eye enucleation in adult Wistar and Lewis rats. The Wallerian degeneration was disclosed by the Fink-Heimer meth...

journal_title：Journal of neuroimmunology

authors： Konno H,Yamamoto T,Iwasaki Y,Suzuki H,Saito T,Terunuma H

更新日期：1989-12-01 00:00:00

abstract：:HLA-DR expression on circulating monocytes varies as a function of disease activity in patients with multiple sclerosis (MS), a putative immunopathological demyelinating disorder. Specifically, monocytes isolated from subjects with active MS exhibit reduced HLA-DR antigen density, and immunoregulatory aberrations such...

journal_title：Journal of neuroimmunology

authors： Ransohoff RM,Tuohy VK,Barna BP,Rudick RA

更新日期：1992-04-01 00:00:00

abstract：:Neuronal damage in Alzheimer's disease (AD) is thought to involve direct toxicity of beta-amyloid peptide (Abeta) and excitotoxicity involving NMDA receptors (NMDARs) and altered Ca(2+) dynamics. Inflammation agents produced by microglia or astrocytes and associated with senile plaques such as the cytokine interleukin...

journal_title：Journal of neuroimmunology

authors： Qiu Z,Gruol DL

更新日期：2003-06-01 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating autoimmune demyelinating disease of the central nervous system (CNS). This study investigated whether expression and activity of the calcium-activated protease calpain correlated with Th1/Th2 dysregulation in MS patients during states of relapse and remission. Calpain expressio...

journal_title：Journal of neuroimmunology

authors： Imam SA,Guyton MK,Haque A,Vandenbark A,Tyor WR,Ray SK,Banik NL

更新日期：2007-10-01 00:00:00

abstract：:Intraplantar (i.pl.) injections of thymulin have been shown to produce hyperalgesia in rats through a prostaglandin E2-dependent mechanism. This study aimed at investigating if such injections can produce sustained activation of spinal neurons by mapping the fos-like-immunoreactivity (FLI) as a marker for this activat...

journal_title：Journal of neuroimmunology

authors： Saadé NE,Lawand HF,Safieh-Garabedian B,Kanaan SA,Atweh SF,Jabbur SJ

更新日期：1999-06-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to...

journal_title：Journal of neuroimmunology

authors： Conrady CD,Drevets DA,Carr DJ

更新日期：2010-03-30 00:00:00

abstract：:Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

journal_title：Journal of neuroimmunology

authors： Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

更新日期：2010-09-14 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a cytokine with pleiotropic actions involved in the pathogenesis of autoimmune disorders, including Multiple Sclerosis (MS). We have first evaluated in silico the involvement of MIF, its homologue D-DT, and the receptors CD74, CD44, CXCR2 and CXCR4 in encephalitogenic T ...

journal_title：Journal of neuroimmunology

authors： Fagone P,Mazzon E,Cavalli E,Bramanti A,Petralia MC,Mangano K,Al-Abed Y,Bramati P,Nicoletti F

更新日期：2018-09-15 00:00:00