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Differences in the amyloid-beta-induced inflammatory response in microglia from C57BL/6 and A/J strains of mice.

Abstract：

:The microglial inflammatory response to Abeta(1-42) stimulation with or without IFN-gamma priming was investigated in low and high responder strains of mice, A/J and C57BL/6, respectively. A/J microglia showed moderate morphological changes upon stimulation with IFN-gamma alone or with Abeta(1-42). Conversely, C57BL/6 microglia showed major changes in their cellular morphology, which were accompanied by a decrease in NO release and a marked increase in TNF-alpha production. These results indicate that the magnitude of the microglial inflammatory response to Abeta is strongly influenced by genetic factors. Individual differences in the regulation of the microglial response may be a key player in the rate of development of the neuropathology of AD.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Dudal S,Morissette C,Lacombe D,Tremblay P,Gervais F

doi

10.1016/j.jneuroim.2004.04.014

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

26-35

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572804001493

journal_volume

153

pub_type

杂志文章

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