当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Dynamics of interferon-beta modulated mRNA biomarkers in multiple sclerosis patients with anti-interferon-beta neutralizing antibodies.

Dynamics of interferon-beta modulated mRNA biomarkers in multiple sclerosis patients with anti-interferon-beta neutralizing antibodies.

Abstract：

:The objective of this study was to evaluate multiple interferon (IFN) specific mRNA biomarkers in multiple sclerosis (MS) patients with anti-IFN-beta neutralizing antibodies (NAB) using a pharmacodynamic study design. Thirty patients were enrolled. Blood samples were drawn at pre-treatment, 4-, 8-h time points following the intramuscular dose of IFN-beta-1a. Total RNA was obtained from peripheral blood cells, processed to cDNA and analyzed using quantitative real-time polymerase chain reaction. Pre-treatment serum samples were analyzed for anti-IFN-beta binding and neutralizing antibodies: 22 patients were NAB negative; equal numbers of the eight remaining patients were either NAB positive or had borderline NAB status. The results showed that early assessment (at 4 h after IFN-beta injection) of mRNAs for Stat-1, MxA, MxB and TRAIL was more sensitive than the later measurements. Furthermore, the NAB positive patients had strongly attenuated gene expression responses on all the mRNAs. Patients with borderline NAB had average responses that appear to be lower than NAB negative patients on several genes, notably Stat-1, TRAIL and beta2 microglobulin.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Santos R,Weinstock-Guttman B,Tamaño-Blanco M,Badgett D,Zivadinov R,Justinger T,Munschauer F 3rd,Ramanathan M

doi

10.1016/j.jneuroim.2006.03.019

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

125-33

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00122-6

journal_volume

176

pub_type

杂志文章

相关文献

JOURNAL OF NEUROIMMUNOLOGY文献大全
  • NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization.

    abstract：:Sympathetic nervous system (SNS) activation mobilizes blood leukocytes. Under these circumstances, both epinephrine (EPI) and neuropeptide Y (NPY) are released. Therefore, we investigated a possible interaction between these transmitters during leukocyte mobilization, using intravenous catheterization of male adult Le...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(02)00278-3

    authors： Bedoui S,Lechner S,Gebhardt T,Nave H,Beck-Sickinger AG,Straub RH,Pabst R,von Hörsten S

    更新日期：2002-11-01 00:00:00

  • Screening of a microvascular endothelial cDNA library identifies rabaptin 5 as a novel autoantigen in Alzheimer's disease.

    abstract：:The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of p...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.09.027

    authors： Delunardo F,Margutti P,Pontecorvo S,Colasanti T,Conti F,Riganò R,Profumo E,Siracusano A,Capozzi A,Prencipe M,Sorice M,Francia A,Ortona E

    更新日期：2007-12-01 00:00:00

  • The intracerebroventricular injection of rimonabant inhibits systemic lipopolysaccharide-induced lung inflammation.

    abstract：:We investigated the role of intracerebroventricular (ICV) injection of rimonabant (500ng), a CB1 antagonist, on lipopolysaccharide ((LPS) 5mg/kg)-induced pulmonary inflammation in rats in an isolated perfused lung model. There were decreases in pulmonary capillary pressure (Ppc) and increases in the ((Wet-Dry)/Dry lun...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.07.001

    authors： Johnson A,Neumann PH,Peng J,James J,Russo V,MacDonald H,Gertzberg N,Feleder C

    更新日期：2015-09-15 00:00:00

  • Expression of common acute lymphoblastic leukemia antigen (CD 10) by myelinated fibers of the peripheral nervous system.

    abstract：:The common acute lymphoblastic leukemia antigen (CALLA), CD10, is a 100-kDa surface glycoprotein endowed with neutral endopeptidase activity, shared by a number of hemopoietic and non-hemopoietic cells. In this report, immunohistochemical and Western blot techniques, using different anti-CD10 monoclonal antibodies, we...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90164-t

    authors： Cadoni A,Mancardi GL,Zaccheo D,Nocera A,Barocci S,Bianchini D,Schenone A,Capello E,Zicca A

    更新日期：1993-06-01 00:00:00

  • No evidence for shared etiology in two demyelinative disorders, MS and PLOSL.

    abstract：:Loss-of-function mutations of DAP12 and TREM2 cause a recessively inherited disease PLOSL, manifesting in brain white matter. The genes of the DAP12-TREM2 signaling receptor are located on 19q13.12 and 6p21.1, to which linkage has been observed also in families affected by another immune-mediated demyelinating disease...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2008.10.005

    authors： Sulonen AM,Kallio SP,Ellonen P,Suvela M,Elovaara I,Koivisto K,Pirttilä T,Reunanen M,Tienari PJ,Palotie A,Peltonen L,Saarela J

    更新日期：2009-01-03 00:00:00

  • Restricted IgG1 subclass of anti-Yo antibodies in paraneoplastic cerebellar degeneration.

    abstract：:Paraneoplastic cerebellar degeneration (PCD) occurs as a non-metastatic manifestation of cancer in a small proportion of patients with certain breast or gynaecological tumours, and is characterised by widespread Purkinje cell loss. Antibodies against a Purkinje cell cytoplasmic antigen, called Yo, that is expressed by...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00445-8

    authors： Amyes E,Curnow J,Stark Z,Corlett L,Sutton I,Vincent A

    更新日期：2001-03-01 00:00:00

  • Evidence for activation of the complement cascade in the hypoglossal nucleus following peripheral nerve injury.

    abstract：:Following hypoglossal nerve transection in adult rats, immunoreactivity for complement factor C3 and one of its degradation products C3d as well as C4d and immunoglobulin G (IgG) was observed in the ipsilateral hypoglossal nucleus. Double-labelling experiments indicated that these antigens were present in perineuronal...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90217-9

    authors： Svensson M,Aldskogius H

    更新日期：1992-09-01 00:00:00

  • Polyneuropathy with anti-sulfatide and anti-MAG antibodies: clinical, neurophysiological, pathological features and response to treatment.

    abstract：:IgM paraproteins often present reactivity to myelin-associated glycoprotein (MAG) and sulfatide. We describe the clinical and neurophysiological findings, and therapy response in 21 patients with IgM paraproteinemic neuropathy (15 with anti-MAG antibodies, 1 with anti-sulfatide antibodies, and 5 with both reactivity),...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2015.02.009

    authors： Campagnolo M,Ferrari S,Dalla Torre C,Cabrini I,Cacciavillani M,Lucchetta M,Ruggero S,Toffanin E,Cavallaro T,Briani C

    更新日期：2015-04-15 00:00:00

  • Evidence that mouse astrocytes may be derived from the radial glia. An immunohistochemical study of the cerebellum in the normal and reeler mouse.

    abstract：:Astrocytic cells of unusual aspect can be detected in the cerebellum of normal mice during the first 4 weeks of life. They are visualized with anti-GFAP (glial fibrillary acidic protein), anti-S100 and anti-vimentin immune sera. Their perikaryons, located in the white matter or in the granular layer, extend long proce...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(85)80009-6

    authors： Benjelloun-Touimi S,Jacque CM,Derer P,De Vitry F,Maunoury R,Dupouey P

    更新日期：1985-07-01 00:00:00

  • Ischemic-like condition releases norepinephrine and purines from different sources in superfused rat spleen strips.

    abstract：:Transmitters and cotransmitters of the sympathetic nervous system are involved in the regulation of a variety of immune cell functions. However, it is not entirely clear what stimuli lead to the release of these molecules in immune organs. In this study, we investigated whether local ischemia can cause the parallel re...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(00)00365-9

    authors： Sperlágh B,Dóda M,Baranyi M,Haskó G

    更新日期：2000-11-01 00:00:00

  • Brain specific autoantibodies in murine models of systemic lupus erythematosus.

    abstract：:Autoantibodies which bind to integral membrane proteins of brain were tested for their ability to bind to cross-reactive antigens on non-neural tissue. Both brain specific autoantibodies and antibodies which bind to cross-reactive antigens were found. There were two types of brain reactive autoantibodies which could n...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(90)90107-x

    authors： Hoffman SA,Madsen CS

    更新日期：1990-12-01 00:00:00

  • Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder.

    abstract：:Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2018.02.013

    authors： Bo M,Niegowska M,Arru G,Sechi E,Mariotto S,Mancinelli C,Farinazzo A,Alberti D,Gajofatto A,Ferrari S,Capra R,Monaco S,Sechi G,Sechi LA

    更新日期：2018-05-15 00:00:00

  • Beta-endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM.

    abstract：:The neurotropic murine coronavirus, MHV-JHM (JHMV) causes encephalitis and paralytic-demyelinating disease in susceptible strains of mice and rats, serving as a model for human demyelinating diseases such as multiple sclerosis. In this communication, we report that a single intracerebral administration of the naturall...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(93)90061-3

    authors： Gilmore W,Moradzadeh DS

    更新日期：1993-10-01 00:00:00

  • MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS).

    abstract：:Recent studies suggest that monocyte activation may play a role in ALS pathogenesis. Therefore, monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), and plasma levels of MCP-1 were measured in 42 sALS patients, 38 healthy and 34 age-related macular degeneration (ARMD) controls. MCP-1 was elevate...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2006.06.008

    authors： Zhang R,Gascon R,Miller RG,Gelinas DF,Mass J,Lancero M,Narvaez A,McGrath MS

    更新日期：2006-10-01 00:00:00

  • Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity.

    abstract：:IgG fractions of sera containing anti-Hu antibodies or control sera were incubated with Hu-positive and Hu-negative cell lines. Anti-Hu IgG specifically localized in the nucleus of Hu-positive cells. Anti-Hu-positive and control sera were incubated with Hu-positive cells and human complement or peripheral blood mononu...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90011-6

    authors： Hormigo A,Lieberman F

    更新日期：1994-12-01 00:00:00

  • T lymphocyte subset abnormalities in peripheral blood from patients with the Guillain-Barré syndrome.

    abstract：:T lymphocytes are probably of pathogenic importance in many autoimmune diseases. Recently, deviations of circulating T-helper (CD4+) subpopulations have been noticed. Blood samples from 12 patients with Guillain-Barré syndrome (GBS) were studied with flow cytometry during their disease course to define circulating T c...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(94)90032-9

    authors： Dahle C,Vrethem M,Ernerudh J

    更新日期：1994-09-01 00:00:00

  • Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine.

    abstract：:Antibody responses to myelin antigens were analysed in 15 patients who developed acute neuroparalytic accidents (ANPA) during post-exposure rabies vaccination using a rabies vaccine prepared on brain tissues and in 30 individuals who were uneventfully vaccinated. High titers (> or = 100) of IgG and IgM antibodies to G...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(98)00153-2

    authors： Laouini D,Kennou MF,Khoufi S,Dellagi K

    更新日期：1998-11-02 00:00:00

  • Prednisone and plasma exchange improve suppressor cell function in chronic inflammatory demyelinating polyneuropathy.

    abstract：:We have recently demonstrated that ConA-induced suppressor cell function is defective in chronic inflammatory demyelinating polyneuropathy (CIDP). To assess whether this defect plays a role in disease activity and its reversal is important in recovery, we studied modifications of ConA-induced suppressor cell function ...

    journal_title：Journal of neuroimmunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0165-5728(98)00266-5

    authors： De Luca G,Lugaresi A,Iarlori C,Marzoli F,Di Iorio A,Gambi D,Uncini A

    更新日期：1999-03-01 00:00:00

  • Expression of the urokinase plasminogen activator and its receptor in HIV-1-associated central nervous system disease.

    abstract：:The urokinase plasminogen activator (uPA) and its receptor (uPAR) play important physiological functions in extracellular proteolysis, as well as cell adhesion and migration. Through dysregulation of these functions, the uPA/uPAR system might be involved in the pathogenesis of AIDS dementia complex (ADC), and, in fact...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2004.08.038

    authors： Sidenius N,Nebuloni M,Sala S,Zerbi P,Price RW,Gisslen M,Hagberg L,Vago L,Lazzarin A,Blasi F,Cinque P

    更新日期：2004-12-01 00:00:00

  • Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis.

    abstract：:TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2005.06.016

    authors： Letiembre M,Echchannaoui H,Ferracin F,Rivest S,Landmann R

    更新日期：2005-11-01 00:00:00

  • Inhibition of T cell superantigen responses following treatment with the kappa-opioid agonist U50,488H.

    abstract：:Previous work in our laboratory has shown that cytokine production by primary murine macrophages, and macrophage cell lines, is inhibited following treatment with the kappa-opioid agonist U50,488H. Furthermore, we have found that the participation of both accessory cells and T cells in an antibody response is suppress...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(97)00018-0

    authors： Guan L,Eisenstein TK,Adler MW,Rogers TJ

    更新日期：1997-05-01 00:00:00

  • Characterization of naïve, memory and effector T cells in progressive multiple sclerosis.

    abstract：:We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all su...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2017.06.001

    authors： Nielsen BR,Ratzer R,Börnsen L,von Essen MR,Christensen JR,Sellebjerg F

    更新日期：2017-09-15 00:00:00

  • Human glioblastoma cell line 86HG39 activates T cells in an antigen specific major histocompatibility complex class II-dependent manner.

    abstract：:The capacity of three different human glioblastoma cell lines to activate human T cells was analysed by measuring major histocompatibility complex (MHC) antigen expression, monokine secretion and lectin, mAb OKT3 and antigen-driven T cell proliferation. All glioblastoma cells tested were able to induce PHA and concana...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(92)90191-m

    authors： Däubener W,Zennati SS,Wernet P,Bilzer T,Fischer HG,Hadding U

    更新日期：1992-11-01 00:00:00

  • Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-α polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.

    abstract：:Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish popula...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2011.04.014

    authors： Mirowska-Guzel D,Gromadzka G,Mach A,Czlonkowski A,Czlonkowska A

    更新日期：2011-07-01 00:00:00

  • EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype.

    abstract：:In dystrophic mdx mice and in Duchenne muscular dystrophy, inflammation contributes to myonecrosis. Previously, we demonstrated that eicosapentaenoic acid (EPA) decreased inflammation and necrosis in dystrophic muscle. In the present study, we examined the effects of EPA and the corticoid deflazacort (DFZ) as modulato...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2013.09.007

    authors： Carvalho SC,Apolinário LM,Matheus SM,Santo Neto H,Marques MJ

    更新日期：2013-11-15 00:00:00

  • Genetic variation at position -1082 of the interleukin 10 (IL10) promotor and the outcome of multiple sclerosis.

    abstract：:Interleukin-10 is a potent immunomodulatory cytokine with possible implications for the pathogenesis of multiple sclerosis. Increased IL10 mRNA expression is associated with stable disease. The interleukin 10 gene is highly polymorphic and certain haplotypes result in differential interleukin-10 expression. The presen...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(99)00256-8

    authors： Mäurer M,Kruse N,Giess R,Toyka KV,Rieckmann P

    更新日期：2000-04-03 00:00:00

  • Infection of mice with lactic dehydrogenase virus prevents development of experimental allergic encephalomyelitis.

    abstract：:A significant reduction in the incidence of experimental allergic encephalomyelitis (EAE) in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate. These results are discussed in terms of the selective in...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/0165-5728(86)90074-3

    authors： Inada T,Mims CA

    更新日期：1986-03-01 00:00:00

  • Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines.

    abstract：:Recent evidence emphasises a pivotal role for dendritic cells (DC) in the control of immunity by priming and tolerising T cells. DC capture and process antigens, express co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. In multiple sclerosis (MS), autoreactive T c...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/s0165-5728(99)00106-x

    authors： Huang YM,Xiao BG,Ozenci V,Kouwenhoven M,Teleshova N,Fredrikson S,Link H

    更新日期：1999-09-01 00:00:00

  • Hyperpolarisation-activated cyclic nucleotide channel 4 (HCN4) involvement in Tourette's syndrome autoimmunity.

    abstract：OBJECTIVES:We previously found that antibodies in Tourette's syndrome (TS) patients' sera reacted with a 120 kDa protein from rat brain tissue. Here, we sought to identify this protein and determine if it was involved in TS pathogenesis. METHODS:The 120 kDa protein was identified using immunoprecipitation, Western blo...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2012.05.009

    authors： Yeh CB,Shui HA,Chu TH,Chen YA,Tsung HC,Shyu JF

    更新日期：2012-09-15 00:00:00

  • Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients.

    abstract：BACKGROUND:Autoreactive antibodies (ARAB) occur more frequently in patients with multiple sclerosis (MS) than in general population and the presence of these antibodies often causes uncertainty regarding the disease course, response to therapy and the diagnosis of MS. METHODS:Retrospective analyses of the ARAB, clinic...

    journal_title：Journal of neuroimmunology

    pub_type： 杂志文章

    doi：10.1016/j.jneuroim.2007.04.008

    authors： Garg N,Zivadinov R,Ramanathan M,Vasiliu I,Locke J,Watts K,Lema J,Rajeswary J,Munschauer FE,Ambrus J Jr,Weinstock-Guttman B

    更新日期：2007-07-01 00:00:00