当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-α polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.

Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-α polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.

Abstract：

:Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated. Increased risk of MS was found for IL6-174 CC homozygotes (OR, 2.88; p<0.00001). In turn, IL1A 4845 TT genotype determined earlier appearance of MS onset whereas IL1B-511 TT genotype was associated with later occurrence of MS but faster disability progression.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Mirowska-Guzel D,Gromadzka G,Mach A,Czlonkowski A,Czlonkowska A

doi

10.1016/j.jneuroim.2011.04.014

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

87-92

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(11)00129-9

journal_volume

236

pub_type

杂志文章

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