Abstract:
:The perpetuation of the inflammatory process in multiple sclerosis (MS) may arise from the failure to eliminate potentially pathogenic autoreactive lymphocytes by programmed cell death (apoptosis). Such impairment may be caused by multiple abnormalities of apoptosis regulatory proteins. In this study, we investigated the expression of survivin, a recently described cell cycle-regulated antiapoptosis protein, in lymphocytes from patients with active relapsing-remitting MS and appropriate controls. Survivin reactivity was detected in intrathecal lymphocytes from some MS patients, but not in resting peripheral lymphocytes. However, mitogen stimulation of resting lymphocytes induced survivin expression, which was significantly higher in stimulated intrathecal and peripheral T lymphocytes from MS patients when compared to controls. In contrast, cellular expression of the antiapoptosis protein Bcl-2 was relatively similar between MS patients and the control groups. Moreover, heightened survivin expression in MS patients correlated with T lymphocyte resistance to apoptosis, and was independent of cellular expression of the death receptor Fas. These findings suggest that upregulation of the antiapoptotic protein survivin in mitogen-stimulated T lymphocytes is a feature of multiple sclerosis.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Sharief MK,Semra YKdoi
10.1016/s0165-5728(01)00389-7subject
Has Abstractpub_date
2001-10-01 00:00:00pages
358-64issue
2eissn
0165-5728issn
1872-8421pii
S0165572801003897journal_volume
119pub_type
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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pub_type: 临床试验,杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/s0165-5728(98)00136-2
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journal_title:Journal of neuroimmunology
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pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
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abstract::The objective of this study was to evaluate multiple interferon (IFN) specific mRNA biomarkers in multiple sclerosis (MS) patients with anti-IFN-beta neutralizing antibodies (NAB) using a pharmacodynamic study design. Thirty patients were enrolled. Blood samples were drawn at pre-treatment, 4-, 8-h time points followi...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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