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Accumulation of passively transferred primed T cells independently of their antigen specificity following central nervous system trauma.

Abstract：

:The central nervous system (CNS) enjoys a unique relationship with the immune system. Under non-pathological conditions, T cells move through the CNS but do not accumulate there. CNS trauma has been shown to trigger a response to CNS self-antigens such as myelin basic protein (MBP). Here, we examined whether the injured CNS tissue undergoes changes that permit T cell accumulation. We found that injury to CNS white matter, such as the optic nerve, led to a transiently increased accumulation of T cells (between days 3 and 21). In Lewis rats with unilaterally injured optic nerves, systemic administration of passively transferred T cells recognizing either self-antigen (MBP) or non-self-antigen (ovalbumin) resulted in accumulation of the T cells in injured optic nerve, irrespective of their antigenic specificity. The effect of the T cells on the damaged nerve, the lack of selectivity in T cell accumulation and the mechanism underlying non-selective accumulation are discussed.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Hirschberg DL,Moalem G,He J,Mor F,Cohen IR,Schwartz M

doi

10.1016/s0165-5728(98)00118-0

subject

Has Abstract

pub_date

1998-08-14 00:00:00

pages

88-96

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(98)00118-0

journal_volume

89

pub_type

杂志文章

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