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Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease.

Abstract：

:Potential interactions between psychostimulant drugs and infection with feline immunodeficiency virus (FIV) on brain metabolism were evaluated. Four groups of cats were studied: control, FIV positive, methamphetamine (MA) exposed, and FIV positive plus MA exposed. Frontal gray matter, frontal white matter, and caudate brain extracts were studied with proton magnetic resonance spectroscopy (1HMRS). In the frontal white matter, FIV-infected cats showed decreases in creatine and choline, while MA-treated cats had elevated gamma-aminobutyric acid (GABA). The decreased glutamate in FIV cats normalized with MA exposure. FIV and MA both affect brain metabolites individually and combined. 1HMRS is useful for evaluating the effects of FIV and drug abuse in the brain.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Cloak CC,Chang L,Ernst T,Barr MC,Huitron-Resendiz S,Sanchez-Alavez M,Phillips TR,Henriksen S

doi

10.1016/j.jneuroim.2003.10.009

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

16-20

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572803004235

journal_volume

147

pub_type

杂志文章

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