Abstract:
:Hemokinin 1 is encoded by preprotachykinin C (PPT-C) mRNA, and has been proposed as a regulator of B and T cell lymphopoiesis. Here we demonstrate the expression of mouse PPT-C mRNA by CD11b+ macrophages, CD11c+ dendritic cells and in the microglial cell line EOC 13.31. Expression was detected in freshly isolated CD11b+CD11c+ bone marrow cells, as well as in M-CSF expanded bone marrow-derived macrophages and GM-CSF expanded bone marrow-derived dendritic cells. There was preferential expression of PPT-C mRNA in dendritic cell subpopulations that were CD11b+, but not B220+ or GR-1+. These studies are the first to demonstrate PPT-C mRNA expression by cells of the myeloid lineage.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Nelson DA,Marriott I,Bost KLdoi
10.1016/j.jneuroim.2004.06.005subject
Has Abstractpub_date
2004-10-01 00:00:00pages
94-102issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(04)00200-0journal_volume
155pub_type
杂志文章abstract::Reactive oxygen species (ROS) produced by activated microglia are deleterious to neurons. In this study, we studied the effect of Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), a superoxide dismutase/catalase mimetic, on the lipopolysaccharide (LPS)-induced degeneration of dopaminergic neurons in rat mesencep...
journal_title:Journal of neuroimmunology
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doi:10.1016/j.jneuroim.2003.10.040
更新日期:2004-02-01 00:00:00
abstract::Although it is generally accepted that pro-inflammatory cytokines produced by cells of the central nervous system play important roles in the communication between the central nervous system and the immune system during sepsis, it is not clear whether these cytokines are produced in the brain under subseptic condition...
journal_title:Journal of neuroimmunology
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abstract::Paraneoplastic cerebellar degeneration (PCD) occurs as a non-metastatic manifestation of cancer in a small proportion of patients with certain breast or gynaecological tumours, and is characterised by widespread Purkinje cell loss. Antibodies against a Purkinje cell cytoplasmic antigen, called Yo, that is expressed by...
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pub_type: 杂志文章
doi:10.1016/s0165-5728(00)00445-8
更新日期:2001-03-01 00:00:00
abstract::Resident glial cells and invading inflammatory cells are responsible for cytokine production within the brain. Astrocytes are known to secrete a variety of cytokines upon stimulation with cytokines themselves, protein kinase C activators, bacterial or viral constituents. Astrocytes also have surface receptors for a wi...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(93)90286-8
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abstract::Using simultaneous dual direct immunofluorescence the effect of high dose intravenous methylprednisolone on the expression of T lymphocyte differentiation antigens in paired cerebrospinal fluid and peripheral blood samples of nine clinically active patients with multiple sclerosis was studied. Corticosteroid treatment...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(91)90043-7
更新日期:1991-03-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2017.07.006
更新日期:2017-09-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(83)90001-2
更新日期:1983-10-01 00:00:00
abstract::To determine clinical features of neurologic disorders associated with anti-glutamic acid decarboxylase antibodies (anti-GAD-Ab), we examined titers and time-dependent changes of anti-GAD-Ab. Six patients, stiff person syndrome (2), cerebellar ataxia (1), limbic encephalitis (1), epilepsy (1), brainstem encephalitis (...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2018-04-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:1988-11-01 00:00:00
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journal_title:Journal of neuroimmunology
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abstract::Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses and the underlying mechanisms in response to metformin in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Metformin reduc...
journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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journal_title:Journal of neuroimmunology
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更新日期:2010-10-08 00:00:00
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journal_title:Journal of neuroimmunology
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更新日期:2019-10-15 00:00:00
abstract::High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that emerges as a promising peripheral marker of inflammation. HMGB1 and C-reactive protein levels were assessed in plasma of control subjects and remitted patients with bipolar disorder (BD). HMGB1 levels were significantly higher in patients with BD as...
journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2001-08-30 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2010.05.005
更新日期:2010-07-27 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(90)90107-x
更新日期:1990-12-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2018.04.007
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journal_title:Journal of neuroimmunology
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更新日期:2002-06-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
abstract::There is circumstantial evidence implicating the pro-inflammatory cytokine tumour necrosis factor (TNF) in the pathogenesis of multiple sclerosis (MS), but there is no direct evidence that TNF can produce demyelination in the central nervous system (CNS). We demonstrate here that single injections of TNF into the dors...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/s0165-5728(00)00213-7
更新日期:2000-07-01 00:00:00